Abstract:BACKGROUND
The primary objective was to evaluate the safety, tolerability and pharmacokinetics of levetiracetam (LEV) administered intravenously at a higher dose and/or faster infusion rate than recommended.
METHODS
Single ascending doses of LEV in 100 mL saline administered by intravenous (IV) infusion (2, 3, 4 g over 15 minutes; 1.5, 2, 2.5 g over 5 minutes) were evaluated in 48 healthy subjects in a randomised, single‐blind, placebo‐controlled study.
RESULTS
Adverse events (AEs) reported following IV admini… Show more
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