Pigmented villonodular synovitis: A review with illustrative case reports

Synovial biopsy

“…It is rarely polyarticular and seldom invades the bone [7,12,16]. Two forms, the localised nodular and the diffuse generalised, are recognised [20]; the diffuse form tends to affect the larger joints [8]. In our patient, the lesions were diffuse and showed pigment-laden cells, foam cells and giant cells.…”

Relationship between iron deposits and tissue damage in the synovium: an ultrastructural study.

“…8 9 In rheumatoid arthritis clinical and biochemical evidence has suggested that such deposits are of considerable importance in determining the chronicity of the inflammatory response. 10 11 Toxic hydroxyl radicals produced from superoxide and hydrogen peroxide in the presence of iron catalysts'2 have the ability to attack and destroy cell membranes, DNA, and other cell constituents.…”

Hemiarthroplasty for Pigmented Villonodular Synovitis of the Shoulder: A Report of Two Cases

“…4 Intra-articular haemorrhage is not a trigger factor. 15 A lipid metabolism disorder and chromosomal deviations (such as trisomy) have also been postulated as causative factors. 7,14 Malignant transformation is extremely rare, 16 and should be suspected when the tumour infiltrates both soft-tissue and bone.…”