Pigmented variant of benign oncocytic lesion of the pharynx

Kurihara, Kenji; Nakagawa, Kenji

doi:10.1111/j.1440-1827.1997.tb04499.x

Cited by 19 publications

(12 citation statements)

References 4 publications

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“…In this study, melanocytes were identified in the nasopharynx. Fontana-Masson staining revealed numerous dendritic melanocytes among the epithelial cells of the glands and overlying epithelium and in the stroma in cases 6 and 9 of the present series, and such a finding has been reported in cases 3 and 4 of the previous study [10,11]. It seems reasonable to postulate that these melanocytes originate in the nasopharynx, since melanocytes are the cells that derived from primordial neural crest and migrate to various sites [1], and that they probably proliferate under the influence of certain trophic substances [22].…”

Section: Discussionsupporting

confidence: 65%

“…Coexistence of melanin pigmentation and oncocytic metaplasia in the same gland characterizes the lesion. There have been only five cases reported thus far in the literature [10,11,22,30]. We report seven additional new cases and review the literature with an attempt to elucidate its possible pathogenesis and histogenesis.…”

Section: Introductionmentioning

confidence: 89%

“…Five cases (cases [1][2][3][4][5] were previously reported in the literature, and seven additional new cases (cases [6][7][8][9][10][11][12] were retrieved from the files of the Department of Pathology, University of Tokushima School of Medicine, Tokushima, Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong, and Department of Pathology, Oita Medical University, Oita. Clinical data were obtained from hospital records for the seven cases (Table 1).…”

Section: Case Selectionmentioning

confidence: 99%

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Melanotic oncocytic metaplasia of the nasopharynx: a report of seven cases and review of the literature

et al. 2004

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We describe seven cases of melanotic oncocytic metaplasia of the nasopharynx and review five other cases in the literature. It is usually a small, brown to black lesion that occurs around the Eustachian tube opening, where abundant seromucinous glands and lymphoid tissue are present. Multiple or bilateral lesions are sometimes seen. All 12 reported cases are of Asian origin. Melanotic oncocytic metaplasia occurs predominantly in men (male:female=11:1), with a mean age of 68 years. Simple excisional biopsy appears to be curative. Microscopically, melanotic oncocytic metaplasia is a combination of oncocytic metaplasia of the epithelium of the gland and melanin pigmentation in its cytoplasm. Fontana-Masson staining and immunohistochemical staining of S-100 protein revealed numerous melanocytes with conspicuous dendrites in the glands and stroma, which probably transfer melanin to adjacent glands. The exact pathogenesis of melanotic oncocytic metaplasia is unknown, but we postulate that the lesion could be related to the oncocytic metaplasia of the seromucinous glands around the Eustachian tube, which is followed by the local production and/or acquisition of the melanin pigment, under the influence of certain neuropeptides in the vicinity. The recognition of melanotic oncocytic metaplasia is of clinical importance, as it may be misdiagnosed as a malignancy to the unwary.

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Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 89%

Section: Case Selectionmentioning

confidence: 99%

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Melanotic oncocytic metaplasia of the nasopharynx: a report of seven cases and review of the literature

et al. 2004

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“…Most such lesions are asymptomatic and are discovered incidentally during endoscopic examination for another disease, and it is rare for them to show melanin pigmentation. They are then usually referred to as melanotic oncocytic metaplasia of the nasopharynx or as a pigmented variant of benign oncocytic lesion of the pharynx [3,8]. This paper describes a case of melanin-pigmented oncocytic metaplasia.…”

Section: Introductionmentioning

confidence: 97%

Melanin pigmented oncocytic metaplasia of the nasopharynx

Hirakawa¹,

Miki²,

Ohmori³

et al. 1999

Virchows Archiv

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A 64-year-old man presented with a history of discomfort of the throat of a few weeks' duration. Nasoscopic examination revealed multiple small, brown pigmentations at the left suprapharynx, the base of the left nasal cavity and the pharyngeal openings of the auditory tube on both sides. Microscopically, the lesion showed a glandular pattern of oncocytic epithelium with abundant pigmented granules and melanophages in the surrounding stroma. Immunohistochemically, the dendritic cells in the basal layer were positive for S-100 protein. Electron microscopic study revealed numerous fully melanized melanosomes and hypertrophied mitochondria in the oncocytic cells. Oncocytic cells do not produce melanin for themselves, melanin granules apparently being transferred from the adjacent dendritic cells to the oncocytic cells.

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“…There have been only a few case reports and small study series. To date, only 20 cases have been reported in the English literature [2][3][4][5][6][7][8][9][10][11]. According to the literature, MOMN occurs predominantly in men (19 men: 1 woman) with a mean age of 68 years (range, 51 to 80 years), and exclusively occurs in East Asians, including Japanese [3,5,6,9], Chinese [2,4,10], Taiwanese [8] and Korean [11].…”

Section: Discussionmentioning

confidence: 99%