Pigmented Purpuric Dermatosis-like Reaction to Topical Fluorouracil

Voelter, William W.

doi:10.1001/archderm.1983.01650350003004

Cited by 10 publications

(1 citation statement)

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“…Pigmented purpuric dermatosis comprises a group of dermatosis of unknown etiology. While gravity and venous insufficiency are important localizing factors in many cases, 1 various medications and chemical agents, including carbromal and meprobamate, 2,3 vitamin B1, 4 topical fluorouracil, 5 nitroglycerin, furosemide, chlordiazepoxide, and trichlomethianzole, 6 tartrazine, 7 glipizide, 8 medroxyprogesterone acetate, 9 and interferon 10 have been implicated as factors responsible for the development of pigmented purpuric dermatosis. An exogenous contact dermatitis, especially with textile dye, may play a possible role in some cases of the itchy purpuric type 11–13 .…”

Section: Discussionmentioning

confidence: 99%

Pigmented purpuric dermatosis and hepatitis profile: a report on 10 patients

Dessoukey¹,

Abdel‐Dayem²,

Omar³

et al. 2005

Int J Dermatology

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Section: Discussionmentioning

confidence: 99%

Pigmented purpuric dermatosis and hepatitis profile: a report on 10 patients

Dessoukey¹,

Abdel‐Dayem²,

Omar³

et al. 2005

Int J Dermatology

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A Case of Isotretinoin-Induced Purpura Annularis Telangiectodes of Majocchi and Review of Substance-Induced Pigmented Purpuric Dermatosis

2014

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IMPORTANCE Medications as well as chemical and food exposures have been causally linked to the development of pigmented purpuric dermatosis (PPD). We describe herein what is to our knowledge the first reported case of isotretinoin-induced PPD. OBSERVATIONS A woman in her 30s presented with purpura annularis telangiectodes of Majocchi on the lower extremities 2 months after initiating isotretinoin for the treatment of refractory nodulocystic acne. CONCLUSIONS AND RELEVANCE We believe isotretinoin was the most likely causative agent in this case because the lesions began after initiation of isotretinoin treatment and resolved shortly after its termination, and the pathologic findings were consistent with other described cases of drug-induced PPD. The lesions have continued to fade, and no new lesions have developed in a 3-month follow-up period. Drug-induced PPD is distinct from idiopathic PPD, and it is important to consider isotretinoin as a potential inciting agent.

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