Pigmented Purpuric Dermatosis Associated with Primary Antiphospholipid Syndrome

Abstract

Pigmented purpuric dermatosis (PPD) is a group of chronic disorders characterized by the extravasation of erythrocytes and marked hemosiderin deposits in the dermis. Schamberg disease is a subtype of pigmented purpuric dermatosis in which nonpalpable purpura is prominent on the lower extremities. No cases of primary antiphospholipid syndrome and pigmented purpuric dermatosis have so far been reported in the literature. We herein report a case of pigmented purpuric dermatosis associated with primary antiphospholipid syndrome.

Progressive pigmented purpuric dermatosis and platelet delta storage pool deficiency in a child

“…[15][16][17] Response to ristocetin 1.5 mg/mL was normal ficiency, diabetes mellitus, drugs, and antiphospholipid syndrome has been reported. 19,20 Progressive PPD is considered difficult to treat. Several regimens consist of topical and systemic steroids, elastic stockings, antipruritic topical preparations, systemic antihistamines, PUVA, griseofulvin, cyclosporin A, bioflavonoids, and ascorbic acid.…”

“…Lesions are chronic and persistent with slow proximal extension, numerous exacerbations, and remissions and can be associated with pruritus . An association with chronic venous insufficiency, diabetes mellitus, drugs, and antiphospholipid syndrome has been reported . Progressive PPD is considered difficult to treat.…”