Pigmented mammary Paget disease mimicking cutaneous melanoma

Meyer-Gonzalez, Teresa; Alcaide-Martín, A.J.; Contreras-Steyls, Marisol; Mendiola, M.; Herrera‐Acosta, Enrique; Herrera, Enrique

doi:10.1111/j.1365-4632.2009.04318.x

Cited by 14 publications

(12 citation statements)

References 7 publications

(7 reference statements)

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“…To our knowledge, six cases of pigmented MPD have been reported to date with dermoscopic findings. Five of these cases presented with irregular pigmentation, and four cases presented with irregular dots/globules and blue–white structures, including blue–white veil and regression structures . These six cases showed dermoscopic features similar to our case, and were indistinguishable from MM under dermoscopy.…”

Section: Discussioncontrasting

confidence: 67%

Pigmented macule on the nipple

et al. 2015

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Section: Discussioncontrasting

confidence: 67%

Pigmented macule on the nipple

et al. 2015

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“…These cases are reported in the literature as ''melanotic carcinoma,'' [22][23][24][25] pigmented mammary Paget disease, 26,27 and blue nevi of the mammary gland proper. 28 Some cases with pigments are merely breast carcinomas that have phagocytized melanin from the adjacent skin.…”

Section: Commentmentioning

confidence: 99%

Metastatic Melanoma Presenting as an Isolated Breast Tumor: A Study of 20 Cases With Emphasis on Several Primary Mimickers

Bacchi

Wludarski²,

Ambaye³

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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Metastatic melanoma may simulate a broad spectrum of primary breast malignancies. Although the application of a simple panel of antibodies assists in rendering the correct interpretation, lesions presenting as isolated breast tumors may introduce a significant diagnostic difficulty, especially when there is inadequate patient history and/or limited biopsy material. Further challenges are introduced by the extraordinary phenotypic plasticity of metastatic melanoma. Awareness of this pattern variance is essential to avoid inappropriate treatment, especially in cases simulating a "triple negative," poorly differentiated carcinoma of the breast.

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“…Paget cells are situated above the basal keratinocytes with some ductal formation, whereas melanoma cells are located in all layers of the epidermis including the basal layer, with intraepidermal pagetoid spread. Also, Paget cells are not seen freely in the dermis, whereas melanoma cells may be present in the dermis 5 , 6 . Nevertheless, as these differences are not often obvious, immunohistochemical staining is necessary.…”

Section: Discussionmentioning

confidence: 99%