Pigmented lesions on the mucosa: a wide range of diagnoses

Fernandes, Darcy; Ferrisse, Túlio Morandin; Navarro, Cláudia Maria; Massucato, Elaine Maria Sgavioli; Onofre, Mirian Aparecida; Bufalino, Andréia

doi:10.1016/j.oooo.2014.11.015

Cited by 9 publications

(10 citation statements)

References 43 publications

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“…An additional limitation was the difficulty in distinguishing between multiple discrete melanotic macules and physiological oral melanin pigmentation. The differentiation of discrete, single, or multiple melanotic macules from physiological oral melanin pigmentation on clinical and histological features is fraught with difficulties, as they share the same clinical features and both can appear at a young age . In the present study, no distinction was made.…”

Section: Discussionmentioning

confidence: 69%

“…Systemic diseases associated with pathological oral melanin pigmentation include neurofibromatosis, Addison disease, Peutz‐Jegher syndrome, McCune‐Albright syndrome, Kaposi sarcoma, and HIV infection. A differential diagnosis of physiological oral melanin pigmentation should also include drug‐induced oral mucosal pigmentation, oral mucosal melanoma, smoker's melanosis, metal poisoning, and inflammatory melanin pigmentation …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Physiological oral melanin pigmentation in a South African sample: A clinical study

Masilana

Khammissa

Lemmer

2017

J of Invest & Clin Dent

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Physiological oral melanin pigmentation in a South African sample: A clinical study

Masilana

Khammissa

Lemmer

2017

J of Invest & Clin Dent

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“…Oral melanoma is generally encountered in the fifth decade, with an increased incidence in men compared with women. A male-to-female ratio of 2.5-3.1 is reported among patients affected with oral melanoma[ 78 , 94 ]. Within the oral cavity, the most common site is the palate, followed by the anterior labial gingiva[ 94 ].…”

Section: Differential Diagnosismentioning

confidence: 99%

Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome

Duan

Zhang

Wang

et al. 2018

WJCC

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Labial and oral melanotic macules are commonly encountered in a broad range of conditions ranging from physiologic pigmentation to a sign of an underlying life-threatening disease. Although Laugier-Hunziker syndrome (LHS) shares some features of labial and oral pigmentation with a variety of conditions, it is a benign and acquired condition, frequently associated with longitudinal melanonychia. Herein, the demographic, clinical, dermoscopic, and pathological aspects of LHS were reviewed comprehensively. The important differential diagnoses of mucocutaneous and nail pigmentation are provided. An accurate diagnosis is crucial to design a reasonable medical strategy, including management options, malignant transformation surveillance, and psychological support. It is important that clinicians conduct long-term follow-up and surveillance due to the potential risks of malignant transformation and local severe complications in some conditions.

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“…A palatal location seems to be the most frequent [2], followed by the labial and the buccal mucosa [2,3]. Nevus color ranges from black, gray, brown, blue, to colorless (2,4,5), and this colorless variety is linked to greater depth of melanocytic proliferation. Blue nevi represent 23% oral nevi [2].…”

Section: Discussionmentioning

confidence: 99%

“…They show an atypical shape because the highly pigmented fusiform melancoytes are not grouped into theca cells and are arranged more deeply in the connective tissue parallel to the epithelial surface [2]. Differential diagnosis of nevi should be made with the other causes of oral mucosa pigmentation: (i) exogenous (ethnic or metal tattoo, drug pigmentation or vascular lesion); (ii) endogenous (hypermelanosis or hypermelanocytosis, whether or not related to systemic signs) [1,4]. Some nevi may be clinically atypical; therefore, it is essential to remove melanomas even if they occur as single lesions.…”

Section: Discussionmentioning

confidence: 99%