Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
Background Inverted follicular keratosis is a rare benign tumor of the follicular infundibulum. Due to its similarity to other benign and malignant cutaneous lesions, it poses a diagnostic challenge. There is limited information regarding the dermatoscopic characteristics of inverted follicular keratosis, and the majority of cases have been reported in patients with fair skin types. Objective To describe the prevalent dermatoscopic features of inverted follicular keratosis, especially in patients with skin of color. Methods We retrospectively analysed 35 histopathologically verified cases of inverted follicular keratosis fom a single university hospital in Turkiye. Results With respect to Fitzpatrick skin phototype, 2 (5.7%), 12 (34.3%), 16 (45.7%) and 5 (14.3%) patients had phototypes 2,3,4, and 5, respectively. Clinically, the majority of inverted follicular keratoses were hypopigmented or nonpigmented (82.9%). Pink-white structureless areas (54.3%), ulceration (54.3%), central keratin mass (42.9%), and blood spots on keratin mass (42.9%) were the most frequent dermatoscopic findings. Pigmented structures were observed as blue-grey structureless areas in 12 lesions and as blue-grey clods in 5 lesions, primarily in Fitzpatrick's phototypes 4 and 5. The incidence of a pink, structureless area and blood spots on ulceration was found to be statistically significantly higher in individuals with fair skin types, while a greater prevalence of blue-grey coloration was observed in those with skin of color (p < 0.05). Conclusion Although our study presents some dermatoscopic distinctions of inverted follicular keratosis, the diagnosis is generally confirmed by histopathology, as the clinical appearance and dermatoscopic findings may not be sufficient to differentiate it from other tumors, especially squamous cell carcinoma or keratoacanthoma. The dermatoscopic characteristics of dark skin are comparable to those of pale skin; however, hyperpigmentation can be more noticeable in skin of color.
Background Inverted follicular keratosis is a rare benign tumor of the follicular infundibulum. Due to its similarity to other benign and malignant cutaneous lesions, it poses a diagnostic challenge. There is limited information regarding the dermatoscopic characteristics of inverted follicular keratosis, and the majority of cases have been reported in patients with fair skin types. Objective To describe the prevalent dermatoscopic features of inverted follicular keratosis, especially in patients with skin of color. Methods We retrospectively analysed 35 histopathologically verified cases of inverted follicular keratosis fom a single university hospital in Turkiye. Results With respect to Fitzpatrick skin phototype, 2 (5.7%), 12 (34.3%), 16 (45.7%) and 5 (14.3%) patients had phototypes 2,3,4, and 5, respectively. Clinically, the majority of inverted follicular keratoses were hypopigmented or nonpigmented (82.9%). Pink-white structureless areas (54.3%), ulceration (54.3%), central keratin mass (42.9%), and blood spots on keratin mass (42.9%) were the most frequent dermatoscopic findings. Pigmented structures were observed as blue-grey structureless areas in 12 lesions and as blue-grey clods in 5 lesions, primarily in Fitzpatrick's phototypes 4 and 5. The incidence of a pink, structureless area and blood spots on ulceration was found to be statistically significantly higher in individuals with fair skin types, while a greater prevalence of blue-grey coloration was observed in those with skin of color (p < 0.05). Conclusion Although our study presents some dermatoscopic distinctions of inverted follicular keratosis, the diagnosis is generally confirmed by histopathology, as the clinical appearance and dermatoscopic findings may not be sufficient to differentiate it from other tumors, especially squamous cell carcinoma or keratoacanthoma. The dermatoscopic characteristics of dark skin are comparable to those of pale skin; however, hyperpigmentation can be more noticeable in skin of color.
Inverted follicular keratosis (IFK) is a rare benign tumor characterized by endophytic growth on the follicular infundibulum. IFK clinically and pathologically resembles other malignant lesions such as squamous and basal cell carcinomas due to similar basosquamous proliferation. Hence, the differentiation of these lesions is important as treatments vary substantially. We present the case of a 60-year-old female with two distinct skin lesions on her scalp. The lesions were excised, and the specimens were sent for histopathologic, immunohistochemistry, and human papillomavirus (HPV) testing. Due to the lesion's location, morphological ambiguity, and predilection for the elderly, differentiation from malignancy or viral-infected skin lesions is difficult. Adequate assessment must be done histopathologically to confirm the benign nature of the lesion as IFK presents usually as a singular lesion. Our case report investigates further whether HPV contributes to the development of IFK in this particular case. In this instance, HPV had no contribution to the development of the lesion.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.