Pigmented Hidrocystomas of the Eye.

Chin, Kimberly; Finger, Paul T.

doi:10.1097/00006324-200212001-00153

Cited by 2 publications

(4 citation statements)

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“…Although ultrahigh-resolution OCT features resolution as low as 3 μm, details of single cells are not seen . Ultrahigh-resolution OCT and UBM allow the identification of the silhouettes of tumors and some architectural features, such as the presence of cystic areas, but not cytologic details . These techniques are less suitable than handheld IVCM to explore the lateral margin of the conjunctiva .…”

Section: Discussionmentioning

confidence: 99%

Handheld In Vivo Reflectance Confocal Microscopy for the Diagnosis of Eyelid Margin and Conjunctival Tumors

et al. 2017

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The clinical diagnosis of conjunctival and eyelid margin tumors is challenging, and new noninvasive imaging techniques could be valuable in this field. OBJECTIVE To assess the diagnostic accuracy of handheld in vivo reflectance confocal microscopy (IVCM) for the diagnosis of eyelid margin and conjunctival tumors. DESIGN A prospective observational study was conducted at University Hospital of Saint-Etienne from January 2, 2011, to December 31, 2016 (inclusion of patients until December 31, 2015, and follow-up until December 31, 2016). A total of 278 consecutive patients with eyelid margin or conjunctival lesions were included. Conjunctival lesions were diagnosed with a conventional clinical examination using a slitlamp and by handheld IVCM. Final diagnoses were established by histopathologic examination for 155 neoformations suspicious for being malignant through clinical and/or IVCM examination that were excised and on follow-up of 12 months or longer for the remaining 140 lesions. MAIN OUTCOMES AND MEASURES Sensitivity, specificity, and positive and negative predictive values for malignant tumors of the conjunctiva and eyelid margin were calculated using clinical examination with slitlamp and handheld IVCM. RESULTS In the 278 patients (136 [48.9%] females; mean [SD] age, 59 [21] years), a total of 166 eyelid margin and 129 conjunctival lesions were included in the analysis. Of the 155 excised neoformations with a histopathologic diagnosis, IVCM showed higher sensitivity compared with clinical examination conducted with the slitlamp for malignant tumors of the eyelid margin (98% vs 92%) and conjunctiva (100% vs 88%). The specificity for malignant eyelid margin tumors was higher for IVCM than for slitlamp examination (74% vs 46%), but slightly less for malignant conjunctival tumors (78% vs 88%). Analysis of all neoformations (155 excised and 140 in follow-up) confirmed these differences in the diagnostic accuracy of the clinical examination and IVCM. The presence of hyperreflective Langerhans cells mimicking malignant melanocytes was the main cause for misdiagnosis of malignant conjunctival tumors with IVCM. CONCLUSIONS AND RELEVANCE Handheld IVCM could be a useful tool for the identification of malignant conjunctival tumors. Further studies are required to confirm the usefulness of this device and identify possible features that can differentiate Langerhans cells from malignant melanocytes to prevent the misdiagnosis of melanoma using IVCM.

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Section: Discussionmentioning

confidence: 99%

Handheld In Vivo Reflectance Confocal Microscopy for the Diagnosis of Eyelid Margin and Conjunctival Tumors

et al. 2017

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“…However, the present case showed a stronger yellowish tone than the previous reports. Indeed, it is difficult to diagnose the cysts from slit-lamp microscopic findings because the locations of lesion on the conjunctiva and coloration are various according to the previous reports [6][7][8] . The sex and age of the patients are also inconsistent.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, although the current case shared histological features of apocrine hidrocystoma including bilobed epithelial cells, and eosinophilic globular materials in the lumen with decapitation secretion, GCDFP-15 was not positive in the epithelium. Chin et al [6] and Kim and Kang [7] also reported two and one patients with conjunctival apocrine hidrocystoma, respectively; however, immunohistochemistry with anti-GCDFP-15 antibody was not tested. p63 is a marker for squamous epithelium and was bilayer stained in this case.…”

Section: Discussionmentioning

confidence: 99%

“…Of the 35 cases with eyelid cystic lesions in the authors' institute, apocrine hidrocystoma was noted in only one case [5] . In fact, apocrine hidrocystoma arising in the conjunctiva is extremely rare, with only four cases reported in the literature [6][7][8] . The clinical diagnosis of apocrine hidrocystoma of the conjunctiva is based on the identification of the cyst by slit-lamp examination and microscopic findings.…”

Section: Dear Editormentioning

confidence: 99%

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