Pigmented epithelioid melanocytoma: a new concept encompassing animal-type melanoma and epithelioid blue nevus

Abstract

Pigmented epithelioid melanocytoma (PEM) is a recently proposed term which encompasses those melanocytic tumours previously designated as ‘animal-type melanoma’ or ‘pigment-synthesising melanoma’ and ‘epithelioid blue nevus’, the latter known to be associated with Carney's complex. We report a case of PEM in a previously well 26-year-old Caucasian woman who presented with a dark pigmented nodule on the anterior chest wall.

A pediatric case of pigmented epithelioid melanocytoma with chromosomal copy number alterations in 15q and 17q and a novel NTRK3‐SCAPER gene fusion

“…Pigmented epithelioid melanocytoma (PEM) represents a group of rare, heavily pigmented melanocytic tumors encompassing lesions previously designated as “animal‐type melanomas” and “epithelioid blue nevi.” Despite the association of multiple such tumors in the setting of Carney complex, most cases of PEM occur spontaneously as solitary neoplasms in otherwise healthy patients. The typical clinical presentation for PEM is a slow‐growing deep‐seated blue or gray nodule, which may clinically resemble cellular blue nevi, pigmented cystic, adnexal or other vascular neoplasms, and occasionally melanoma .…”

Pigmented epithelioid melanocytoma with nodal melanosis: A rare cause of cystic cervical lymphadenopathy

“…Given its malignant potential, surgical resection with clear margins is necessary. Gavriilidis et al further advocate routine sentinel lymph node sampling.…”

Dermatological and endocrine elements in Carney complex (Review)

“…Different melanocyte-derived tumors have been identified such as epithelioid blue nevi and pigmented epithelioid melanocytoma (19,20). Pigmented epithelioid melanocytoma was previously termed 'animal-type melanoma' (21). Despite being linked to this hereditary syndrome, blue nevus-derived tumors, underlying different grades of pigmentation, do not typically have a neonatal presentation (22).…”