Pigmented contact dermatitis from azo dyes

Kgzuka, Takehito; Tashiro, Minoru; Sano, Shigeharu; Fujimoto, Keiichi; Nakamura, Yumi; Hashimoto, Seiichi; Nakaminami, Gen

doi:10.1111/j.1600-0536.1980.tb04958.x

Cited by 44 publications

(16 citation statements)

References 8 publications

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“…CI Solvent Yellow 14 is an azo dye used in paints. It has previously been reported as a contact allergen in different cosmetics . It has also been used in textiles and food, but is now prohibited in food in the EU and is listed in REACH annex XVII, entry 43 (Azocolourants and Azo dyes) .…”

Section: Discussionmentioning

confidence: 99%

CI Solvent Yellow 14 (Sudan I) identified as the allergen in a plastic part of glasses

et al. 2019

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Section: Discussionmentioning

confidence: 99%

CI Solvent Yellow 14 (Sudan I) identified as the allergen in a plastic part of glasses

et al. 2019

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“…Allergy to these ingredients are reported. [17][18][19][20][21] Bindi dermatitis due to thimerosal and gallate mix has also been reported. 12 …”

Section: Discussionmentioning

confidence: 99%

A Clinical Study on Kumkum and Bindi Dermatitis and Their Relevance to Patch Testing

Babu¹,

K²

2016

jemds

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BACKGROUNDApplying kumkum and sticker bindi on the forehead and hair parting is universally followed by Hindu women as a traditional symbol. This tradition is more followed in south India, especially by married women as sindoor in hair parting. There are more complaints of itching, burning and redness on forehead and hair parting where sticker bindi and kumkum are applied in women attending dermatology outpatient department.Aim of the study is to evaluate kumkum and sticker bindi dermatitis with relevance to patch testing. MATERIALS AND METHODS50 clinically suspected cases of dermatitis over forehead (Glabella) and hair parting were taken up for study. Patch testing was done with patients own kumkum, sticker bindi, turmeric allergen (As turmeric is used in the preparation of kumkum), nickel (as nickel is one of the major ingredients in sticker bindi). RESULTSOut of 50 cases tested, 38 patients (76%) were positive for patch testing and results are statistically significant. CONCLUSIONDermatitis (allergic contact dermatitis) to kumkum, sticker bindi are proved by the patch testing. Kumkum and sticker bindi have a wide popularity among people as cosmetics and also for their traditional and religious beliefs. Application of them is inevitable in the community, so an alternative should be found (heated and dried kumkum which is non-allergenic). As the incidence of kumkum dermatitis is raising, we can think of inclusion of kumkum and turmeric in Indian standard series (ISS) of allergens. KEYWORDSKumkum, Bindi, Dermatitis, Patch Test. HOW TO CITE THIS ARTICLE: Babu VA, Venkateswaran KS. A clinical study on kumkum and bindi dermatitis and their relevance to patch testing. J. Evolution Med. Dent. Sci. 2016;5(94):6919-6923, DOI: 10.14260/jemds/2016/1566 BACKGROUND Application of kumkum and sticker bindi on forehead, glabellar region is universally followed by Hindu women as a traditional symbol. Married women apply kumkum in the hair parting as sindoor as a religious custom. Complaints of itching, burning, vesiculation, pigmentation in and around these areas has increased in the recent past. Turmeric is used in the preparation of kumkum, the turmeric is dried and powered and mixed with a bit of slaked lime which turns the rich yellow power in to red colour. 1, 2 Turmeric is known as golden spice of life. 3 It has been used in India as a medicinal plant and held sacred from time immemorial. Turmeric contains 5% of essential oils and up to 3% of curcumin, a polyphenol compound responsible for the yellow colour of turmeric and is the most active pharmacological agent. 4 The active ingredient (curcumin) can be extracted by dissolving turmeric in Financial or Other, Competing Interest: None. Submission 20-10-2016, Peer Review 14-11-2016, Acceptance 19-11-2016, Published 24-11-2016. Corresponding Author: Dr. Venna Ashok Babu, H. No. 11-2-80/1, Balaji Nagar, Wyra Road, Khammam-507001. E-mail: drashok24@gmail.com DOI: 10.14260/jemds/2016/1566 ethanol and evaporation of the solvent. 5 Apart from allergic contact ...

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“…However, despite its carcinogenicity for rodents Sudan I was not classified as carcinogenic for humans by the Interna- tional Agency for Research on Cancer (IARC) [272,273]. Sudan I is a potent allergen and sensitizer eliciting allergic contact dermatitis in humans [274]. It is metabolized by several routes (Scheme 37), primarily by oxidative or reductive reactions in the liver, whereas the C-hydroxylated metabolites 4'-OH-Sudan I and 6-OH-Sudan I were found to be the major products of Sudan I oxidation in vivo.…”

Section: Sudan Dyes Are Potential Carcinogens and Mutagens For Humansmentioning

confidence: 98%

Biological Properties of Schiff Bases and Azo Derivatives of Phenols

Przybylski¹,

Huczyński²,

Pyta³

et al. 2009

COC

387

206

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Aza-derivatives of phenols such as Schiff bases and hydrazones are an important and interesting group of chemical compounds. They exhibit a number of biological activities and play an important role in the regulation of many biochemical processes. Due to these properties, these compounds are potentialy useful for the design and production of novel anticancer, antimalaria, antivirus and antimicrobial drugs.The primary aim of the present review is to compare selected groups of phenol-derivatives containing azo-, heterocyclic, aromatic, alkyl and sugar moieties in view of their potential use and undesired effects, since some of them are widely used as dyes in the industry.Despite the vast number of azo derivatives of phenols which were synthesized and tested with respect to their biological activities, there is a continuous search for compounds of this group which might exhibit interesting, new biological effects.The main contribution to the development of Schiff base chemistry undoubtedly came from pharmaceutical research that began with the early studies of Hugo Schiff in the 19th century. Indeed, a vast number of publications on this matter underline the relevance of Schiff bases and related compounds in chemistry, pharmacy, biochemistry and industry. GOSSYPOLGossypol (Scheme 1) is a bisesquiterpene with interesting physico-chemical properties and pronounced biological activities. Despite many useful biological and physiological characteristics the main obstacle in using this compound as a drug is its relatively high toxicity and some other side effects [1][2][3][4][5]. The toxicity of gossypol is directed mainly towards the reproductive system, liver, heart and lipid membranes [6,7]. In the last thirty years biological and medical applications of gossypol and its derivatives mainly of its Schiff bases were on the focus of research. More than two thousand publications about gossypol and its derivates in medical therapy show the importance of this compound today. Scheme 1.

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Pigmented contact dermatitis from azo dyes

Cited by 44 publications

References 8 publications

CI Solvent Yellow 14 (Sudan I) identified as the allergen in a plastic part of glasses

CI Solvent Yellow 14 (Sudan I) identified as the allergen in a plastic part of glasses

A Clinical Study on Kumkum and Bindi Dermatitis and Their Relevance to Patch Testing

Biological Properties of Schiff Bases and Azo Derivatives of Phenols

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