Pigmented contact dermatitis

Ebihara, Tamotsu; Nakayama, Hideo

doi:10.1016/s0738-081x(97)00072-2

Cited by 33 publications

(34 citation statements)

References 10 publications

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“…PCD is a rare variant of non-eczematous contact dermatitis, which is believed to be caused by repetitive contacts with very small amounts of allergens, such as washing powder, fragrance or cosmetics (1516). The small amount of allergen induces spongiosis in epidermis, rather than the classical symptoms of contact dermatitis that include erythema, edema and vesicle formation.…”

Section: Discussionmentioning

confidence: 99%

“…Presence of liquefactive degeneration of basal layer and dense inflammatory cell infiltration in dermis suggests accumulative inflammatory damage (16), therefore topical agents of anti-inflammatory activity, not depigmenting or whitening agents should be used first. According to this well-defined step-by-step approach, among 12 patients who suffered with refractory, long-lasting dyspigmentation was considerably improved (Figs.…”

Section: Discussionmentioning

confidence: 99%

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Acquired Bilateral Dyspigmentation on Face and Neck: Clinically Appropriate Approaches

et al. 2016

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Facial dyspigmentation in Asian women often poses diagnostic and therapeutic challenges. Recently, a distinctive bilateral hyperpigmentation of face and neck has occasionally been observed. This study was performed to investigate the clinico-pathological features of this dyspigmentation as well as proper treatment approaches. We retrospectively investigated the medical records including photographs, routine laboratory tests, histopathologic studies of both lesional and peri-lesional normal skin and patch test of thirty-one patients presented acquired bizarre hyperpigmentation on face and neck. The mean age of patients was 52.3 years and the mean duration of dyspigmentation was 24.2 months. In histologic evaluations of lesional skin, a significantly increased liquefactive degeneration of basal layer, pigmentary incontinence and lymphocytic infiltration were noted, whereas epidermal melanin or solar elastosis showed no statistical differences. Among 19 patients managed with a step-by-step approach, seven improved with using only topical anti-inflammatory agents and moisturizer, and 12 patients gained clinical benefit after laser therapy without clinical aggravation. Both clinical and histopathologic findings of the cases suggest a distinctive acquired hyperpigmentary disorder related with subclinical inflammation. Proper step-by-step evaluation and management of underlying subclinical inflammation would provide clinical benefit.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acquired Bilateral Dyspigmentation on Face and Neck: Clinically Appropriate Approaches

et al. 2016

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“…22 Moreover, several common dermatoses, such as drug eruption and contact dermatitis, may hyperpigmented lesions. [23][24][25][26] Hyperpigmented skin lesions, especially PIH, are very common in individuals with dark skin, 27 and the diagnosis is usually made on the basis of history and physical examination. Three of our patients were initially diagnosed with PIH by the clinical and histopathological findings, and only later in the course of the disease were biopsies performed which confirmed MF.…”

Section: Discussionmentioning

confidence: 99%

Hyperpigmented mycosis fungoides: An unusual variant of cutaneous T-cell lymphoma with a frequent CD8+ phenotype

Pavlovsky

Mimouni

Amitay‐Laish

et al. 2012

Journal of the American Academy of Dermatology

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“…The specimens showed interface dermatitis with lichenoid (2/5) or vacuolar alteration (3/5), necrotic keratinocytes (4/5) and dermal melanophages (5/5) (Fig. 2 and Table 1), consistent with pigmented contact dermatitis (PCD) 8,9 . Therefore, we suggest that pigmentary complication by CI for AA corresponds to PCD.…”

Section: Resultsmentioning

confidence: 77%

Pigmented contact dermatitis due to therapeutic sensitizer as complication of contact immunotherapy in alopecia areata

Inui¹,

Nakajima²,

Toda³

et al. 2010

The Journal of Dermatology

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Pigmentary complication by contact immunotherapy (CI) for alopecia areata (AA) has been reported but its pathophysiology remains unknown. To characterize pigmentary complication by CI and its pathophysiology, we examined the incidence of hyperpigmentation in 186 consecutive patients treated with CI using diphenylcyclopropenone. From clinical data of AA totalis (AAT) or universalis (AAU) patients (n = 78), we studied the correlations between this complication and age, sex, atopic background, duration and treatment responsiveness, duration of CI, final concentration of diphenylcyclopropenone and administration of anti-histamines by χ(2)-test or Mann-Whitney U-test. Additionally, the histopathology of pigmentation was studied. As a result, 11 (5.91%) of the 186 patients had hyperpigmentation in this series. All of them had AAT or AAU, suggesting that the pigmentation is apt to occur in severe AA. When the AAT or AAU patients with (n = 11) and without hyperpigmentation (n = 67) were compared, those with pigmentation showed poorer responsiveness to CI (P < 0.05) but no significant tendency for other factors. Histopathologically, skin specimens showed lichenoid or vacuolar interface dermatitis with necrotic keratinocytes and dermal melanophages, consistent with pigmented contact dermatitis (PCD). Together, pigmentary complication by CI corresponds to PCD from therapeutic sensitizer, representing clinical indicator of poor responsiveness.

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Pigmented contact dermatitis

Cited by 33 publications

References 10 publications

Acquired Bilateral Dyspigmentation on Face and Neck: Clinically Appropriate Approaches

Acquired Bilateral Dyspigmentation on Face and Neck: Clinically Appropriate Approaches

Hyperpigmented mycosis fungoides: An unusual variant of cutaneous T-cell lymphoma with a frequent CD8+ phenotype

Pigmented contact dermatitis due to therapeutic sensitizer as complication of contact immunotherapy in alopecia areata

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