Pigmented Basal-Cell Carcinoma in Verrucous Nevi

Winer, Louis H.; Levin, Gerald

doi:10.1001/archderm.1961.01580120072017

Cited by 22 publications

(8 citation statements)

References 5 publications

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“…The two present cases indicate that seborrheic keratosis possesses the pluripotentiality to develop hamartomatous, benign, or malignant neoplasms, and, in particular, follicular tumors. In conclusion, the present study has shown that seborrheic keratosis should be considered to be a precancerous lesion, as are nevus sebaceous (30) and epithelial nevi (31). Important clinical signs of malignant change in seborrheic keratosis are considered to include an ulceration or a nodule in the lesion.…”

Section: Discussionmentioning

confidence: 56%

Two Cases of Basal Cell Carcinoma Arising in Seborrheic Keratosis

Akasaka

Kon

1997

The Journal of Dermatology

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The present study reports two cases of basal cell carcinoma arising in seborrheic keratosis. The first case is a seventy-three-year-old female who presented with a blackish nodule arising from a pigmented lesion on her chest. Histopathological analysis of the nodule and the pigmented lesion revealed a basal cell carcinoma with hair follicular differentiation and an acanthotic seborrheic keratosis, respectively. The second case is a seventy-year-old female with a blackish nodule arising from a pigmented lesion on her back. Histological analysis of the nodule revealed an atypical basaloid cell mass surrounded by a seborrheic keratosis lesion. In addition to the coexisting seborrheic keratosis with the basal cell carcinoma, a basaloid follicular hamartoma that showed multiple hamartomatous hair follicles or small cysts replaced by a branching cord or lace-like network of basaloid cells surrounded by fibrovascular stroma was identified. We concluded that both cases presented a rare combination of a seborrheic keratosis which underwent a malignant change to basal cell carcinoma. It appears that both basal cell carcinomas and seborrheic keratosis may derive from a similar source: pluripotential cells of either the epidermis or hair follicle epithelium.

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Section: Discussionmentioning

confidence: 56%

Two Cases of Basal Cell Carcinoma Arising in Seborrheic Keratosis

Akasaka

Kon

1997

The Journal of Dermatology

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“…The coexistence of a follicular tumor and sweat gland tumor arising in seborrheic keratosis resembles a hamartomatous lesion such as nevus sebaceous (19) or epithelial nevus (20). It is well known that nevus sebaceous in the adolescent and the adult are often associated with benign or malignant adnexal tumors, including the following: basal cell carcinoma; pilar tumors such as trichilemmoma, trichoepithelioma, follicular or pilar hamartoma; proliferating pilar tumor and sebaceous adenoma; apocrine tumors such as apocrine adenoma, syringocystadenoma pappilliferum, apocrine hidrocystoma, and apocrine carcinoma, and eccrine sweat gland tumors such as eccrine spiradenoma, eccrine acrospiroma, and adnexal carcinoma (21,22).…”

Section: Discussionmentioning

confidence: 99%

A Possible Case of Eccrine Poroma Arising in Seborrheic Keratosis with Partial Intermediate Malignancy and Tumor of the Follicular Infundibulum

Akasaka

Kon

1997

The Journal of Dermatology

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An eighty-year-old woman presented with a eccrine poroma that appeared to have arisen in a seborrheic keratosis lesion on the right side of her abdomen. The tumor consisted of a brownish, flat, elevated lesion with an eroded nodule at its periphery. Histopathological analysis of the flat, elevated lesion revealed benign basaloid and squamoid cells that showed acanthotic upward proliferation, suggesting a seborrheic keratosis. The eroded nodule showed irregular proliferation of slight atypical squamoid cells with, in parts, ductal structures in the upper dermis, suggesting that it was an eccrine poroma with partial intermediate malignancy. In addition to the eroded nodule, an occult tumor clinically accompanied the seborrheic keratosis. Histopathology of the occult tumor revealed fenestrated columns and cords of pale epithelial cells attached to the base of the seborrheic keratosis lesion, which was diagnosed as a tumor of the follicular infundibulum. Although reports of seborrheic keratosis transforming into a sweat gland tumor are rare, the present case suggests that seborrheic keratosis may develop into benign or malignant adnexal tumors, including sweat gland and follicular tumors. Thus, seborrheic keratosis should be considered as a possible precursor of adnexal tumor.

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“…In contrast, other instances remain rare or controversial, including basal‐cell epithelioma arising within seborrheic keratosis or development of squamous‐cell carcinoma within an epidermal cyst. Previous reports have indicated that the linear epidermal nevus may serve as a site of development for additional skin tumors 2–8 . However, judging from the paucity of such publications, this is likely an infrequent phenomenon.…”

Section: Discussionmentioning

confidence: 99%

“…The latter, often referred to as a systematized epidermal nevus, may be associated with a variety of congenital malformations such as skeletal deformities and abnormalities of the central nervous system 1 . Moreover, an epidermal nevus may be the site of development of other neoplasms, notably basal‐cell epifheliomata 2–4 and squamous‐cell carcinomas 5–7 . A recent case report implicated the epidermal nevus as a locus for the development of keratoacanthomas as well 8 .…”

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confidence: 99%