Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence

Wu, Di; Yu, Feng; Wang, Rui; Jiang, Jin; Guan, Quanquan; Xu, Yang; Wei, Hongcheng; Xia, Yankai; Luo, Yongming

doi:10.1016/j.jare.2022.09.004

Cited by 125 publications

(59 citation statements)

References 35 publications

(36 reference statements)

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“…With the widespread application of NMs in sunscreen products, pharmaceuticals, cosmetics, and construction materials, large amounts of NMs are entering people's living environment, posing health risks to researchers, workers, and consumers. According to a recent study, scientists have detected ultrafine artificial particles in human thrombosis [ 166 ]. This result sheds light on the possible involvement of NMs in human AS formation.…”

Section: Limitations and Prospectsmentioning

confidence: 99%

Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors

Chen¹,

Yuan²,

Zhang³

et al. 2023

J Nanobiotechnol

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Atherosclerosis is one of the most common types of cardiovascular disease and is driven by lipid accumulation and chronic inflammation in the arteries, which leads to stenosis and thrombosis. Researchers have been working to design multifunctional nanomedicines with the ability to target, diagnose, and treat atherosclerosis, but recent studies have also identified that nanomaterials can cause atherosclerosis. Therefore, this review aims to outline the molecular mechanisms and physicochemical properties of nanomaterials that promote atherosclerosis. By analyzing the toxicological effects of nanomaterials on cells involved in the pathogenesis of atherosclerosis such as vascular endothelial cells, vascular smooth muscle cells and immune cells, we aim to provide new perspectives for the prevention and treatment of atherosclerosis, and raise awareness of nanotoxicology to advance the clinical translation and sustainable development of nanomaterials. Graphical Abstract

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Section: Limitations and Prospectsmentioning

confidence: 99%

Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors

Chen¹,

Yuan²,

Zhang³

et al. 2023

J Nanobiotechnol

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“…Although some studies have reported that MPs/NPs have been found in human tissues such as blood and placenta samples, there is no epidemiological study on the quantitative analysis of NPs in the human body 16,17 . A recent study found MPs particles in human thrombi samples 18 . Due to the small particle size, NPs can easily cross biological barriers and pose greater health risks than MPs 19 .…”

Section: Introductionmentioning

confidence: 99%

“…16,17 A recent study found MPs particles in human thrombi samples. 18 Due to the small particle size, NPs can easily cross biological barriers and pose greater health risks than MPs. 19 Additionally, NPs can enter the body through the alimentary canal, respiratory tract, and skin penetration.…”

mentioning

confidence: 99%

Integrated fecal microbiome and metabolome analysis explore the link between polystyrene nanoplastics exposure and male reproductive toxicity in mice

Liu

Han

et al. 2023

Environmental Toxicology

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Microplastics (MPs) and nanoplastics (NPs) are novel environmental pollutants that are ubiquitous in the environment and everyday life. NPs can easily enter the tissues and have more significant potential health risks due to their smaller diameter. Previous studies have shown that NPs can induce male reproductive toxicity, but the detailed mechanisms remain uncertain. In this study, intragastric administration treated mice with polystyrene NPs (PS‐NPs, 50, and 90 nm) at 3 and 15 mg/mL/day doses for 30 days. Then, the fresh fecal samples were collected from those mice that the exposure doses of 50 nm PS‐NPs at 3 mg/mL/day and 90 nm at 15 mg/mL/day for subsequent investigations of 16S rRNA and metabolomics according to significant toxicological effects (Sperm number, viability, abnormality, and testosterone level). The conjoint analysis findings indicated that PS‐NPs disrupted the homeostasis of the gut microbiota, metabolism, and male reproduction, suggesting that abnormal gut microbiota‐metabolite pathways may be important in PS‐NPs‐induced male reproductive toxicity. Meanwhile, the common differential metabolites such as 4‐deoxy‐Erythronic acid, 8‐iso‐15‐keto‐PGE2, apo‐10′‐violaxanthin, beta‐D‐glucosamine, isokobusone, oleamide, oxoadipic acid, sphingosine induced by 50 and 90 nm PS‐NPs might be used as biomarkers to explore PS‐NPs‐induced male reproductive toxicity. In addition, this study systematically demonstrated that nano‐scale PS‐NPs induced male reproductive toxicity via the crosstalk of gut microbiota and metabolites. It also provided valuable insights into the toxicity of PS‐NPs, which was conducive to reproductive health risk assessment for public health prevention and treatment.

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“…For example, microparticles varying from 2.1 to 26 μm in size were found in human blood and may contribute to the development of several diseases such as kidney stones, gallstones, and cardiovascular and cerebrovascular diseases. 2 Consequently, a systematic analysis of these harmful particles is of great importance and reliable separation of them from blood is an essential upfront step. However, considering the wide range of particles in terms of size, type, and shape, there is still a lack of standardized method of separation.…”

Section: ■ Introductionmentioning

confidence: 99%

“…More importantly, these particles (e.g., Pb, Cd, polyethylene, and polystyrene) are oftentimes non-biodegradable and thus can negatively affect human health. For example, microparticles varying from 2.1 to 26 μm in size were found in human blood and may contribute to the development of several diseases such as kidney stones, gallstones, and cardiovascular and cerebrovascular diseases . Consequently, a systematic analysis of these harmful particles is of great importance and reliable separation of them from blood is an essential upfront step.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Separation of EGaIn Microparticles from Human Blood Based on Dielectrophoresis Force and a W-Type Electrode

Guan

Wang

et al. 2023

Langmuir

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Harmful particles such as heavy metal particles in the human body can cause many problems such as kidney stones, gallstones, and cerebrovascular diseases. Therefore, it is critical to separate them from the blood and perform a systematic analysis as early as possible. Here, we apply eutectic gallium indium (EGaIn) microparticles as a model to study the separation of particles from blood, thanks to their properties of low toxicity, excellent degradability, and negligible vapor pressure. In particular, the dielectrophoresis (DEP) separation method is employed to separate EGaIn of different sizes and characteristics in blood. First, the screen-printing method is used to create EGaIn microparticles with diameters of 15, 23, 18, and 11 μm. According to the lifetime test, these microparticles can last more than 1 month, as evidenced by their surface oxidation characteristics. Moreover, a DEP platform with W-type electrodes is developed to sort EGaIn particles from whole human blood. The results show that a sorting efficiency of 95% can be attained, which is similar to the separation efficiency of 98% achieved by finite element analysis (FEA) using COMSOL software based on the orthogonal array experiment method. The proposed study successfully validates the use of the DEP method to separate particles from human blood, providing insights into heavy metal particle separating, drug screening, and cell sorting and potentially broadening the applications in environmental analysis, food engineering, and bioengineering.

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Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence

Cited by 125 publications

References 35 publications

Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors

Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors

Integrated fecal microbiome and metabolome analysis explore the link between polystyrene nanoplastics exposure and male reproductive toxicity in mice

Fabrication and Separation of EGaIn Microparticles from Human Blood Based on Dielectrophoresis Force and a W-Type Electrode

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