Pigment Metabolism after Blood Transfusion

Vaughan, Janet

doi:10.1136/bmj.1.4243.548

Cited by 14 publications

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References 3 publications

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“…Vaughan (2861) did not find hematinemia in increased blood destruction following the injection of long-stored blood.…”

Section: Metabolism Of Hematinmentioning

confidence: 89%

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Hematin compounds and bile pigments; their constitution, metabolism, and function, by R. Lemberg and J.W. Legge.

Legge¹,

Lemberg²

1949

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II. METHODS or INVESTIGATION* Only the naturally occurring hile pigments of type IXa are discussed.* .\11 tlie al).s()r[)ti()ii curves of the "hiliverdiiis" in Heihiieyers hook (121-i) are ohviously tliose of niixtiirt's of liiliverditi witli hiliruliiii (pages 1(51, 1()7) and other * The term K-urobilin is, however, used by the Fischer school to denote a mixture of side chain isomerides of mesobilene-(b) in contradistinction to mesobilene-(b) IXa.* It is not certain, however, whether the albumin is the only plasma protein able to combine with hematin (c/. Miller and Ailing, 191f9a).* Keilin and Smith {1502a) have been unable to confirm the results of Virtanen and Laine.XII. HEMOGLOBIN CATABOLISM, II * Cf., however, Bittner and Watson {28-3a). CHAPTER XIII FORMATION OF HEMOGLOBIN AND SYNTHESIS OF PORPHYRINSIN THE ANIMAL BODY * The hemoglobin found occasionally in some species of Daphnia (Fox,937aa) does not appear to have an essential physiologic function, although, like the hematin compounds mentioned above, it is passed on in parthenogenetic eggs. Even the chlorocruorin or erythrocruorin of serpulimorphid worms does not appear to be essential (Fox, 937a).Glaucobilin. See Mesobiliverdin. Globan, 211. See also Globin (denatured). Globin, denatured, 240, 258 combination with heme, 232 electrometric titration, 255 in erythrocytes, 525 isoelectric point, 255 renaturation, 259 Globin, native, 230, 258, 568 amino acids. See Hemoglobin. combination, with hematins, 239 with metalloporphyrins, 240 with porphyrins, 240 denaturation, 255 ff. 734 SUBJECT INDEX Globin native (contd.) electrometric titration, 255 differential of globin and hemiglobin, 244 fate in hemogIol>in breakdown, 548, 568 frictional ratio, 250 isoelectric point, 255 molecular weight, 250 oxidation, in autoxidation of hemoglobin, 390 in denaturation, 395, 478 preparation, 258 specificity, 321. See also Hemoglobin. synthesis in vivo, 610 Glutathione as anticatalase, 412 and choleglobin formation, 477, 478, 517 and dehydroascorbic acid, 470, 517, 518 in erythrocyte, 516, 522, 619 and hem/globin, 522 as substrate of cytochrome c, 376 Glycine, in porphyrin s\nthesis, 637 Gmelin reaction, 109, 112 (table), 116, 138 Green hemins, 201, 456, 490. See also Chlorophyll hemins, Pheophorbide kemin, Verdochemochrome.

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“…Vaughan (2861) did not find hematinemia in increased blood destruction following the injection of long-stored blood.…”

Section: Metabolism Of Hematinmentioning

confidence: 89%

“…This is confirmed by measurements of the urobilinogen excretion in the feces, or of the transitory increase of serum bilirubin which occurs after the transfusion of blood which has been stored long enough for degenerative changes to have taken place {cf. above and 2861,2967).…”

Section: The Dying Cell In Vivomentioning

confidence: 91%

Hematin compounds and bile pigments; their constitution, metabolism, and function, by R. Lemberg and J.W. Legge.

Legge¹,

Lemberg²

1949

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“…of donor blood in a few hours can be observed without any accompanying haemoglobinasmia. Vaughan [1942] has demonstrated that methaemalbumin [Fairley, 1940] cannot be detected in the recipient's plasma after the transfusion of stored blood, and this finding excludes the occurrence of all but small degrees of intravascular haemolysis.…”

Section: Discussion In Vivo Survival Testsmentioning

confidence: 99%

“…The time 4-6 hours was chosen because it has been shown that the rise in serum bilirubin after the transfusion of stored blood is maximal at this time [Vaughan, 1942].…”

Section: Resultsmentioning

confidence: 99%

IN VIVO SURVIVAL IN THE HUMAN SUBJECT OF TRANSFUSED ERYTHROCYTES AFTER STORAGE IN VARIOUS PRESERVATIVE SOLUTIONS

Mollison¹,

Young²

1942

Exp Physiol

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The results of the commonly accepted in vitro tests, made upon samples of stored blood, are fallacious indicators of the state of preservation of biological activity, as judged by the subsequent in vivo survival of the erythrocytes. In the selection of preservative solutions, however, in vitro tests may have a negative value. For instance, if blood hæmolyses rapidly in a given solution, that solution may safely be rejected. If, however, a solution is found to be successful in inhibiting hæmolysis, it will not necessarily succeed in prolonging in vivo survival. The degree to which stored erythrocytes resist vigorous shaking in the presence of glass beads is not correlated with their survival time in vivo. Although the osmotic fragility of stored erythrocytes, as usually measured, has led to many fallacious conclusions as to the value of different blood preservatives, a revised test in which the erythrocytes are first treated with fresh plasma may be found more useful. The in vivo survival of blood stored without carbohydrate is almost as good as that of fresh blood when the period of storage is 6 days or less. I. H. T., sodium citrate, and heparin all seem to have a similar effect upon subsequent survival; defibrinated blood seems to survive slightly better. In the treatment of anæmia it is suggested that the limit of 6 days is not exceeded when using blood stored in one of these solutions. Blood stored for 14 days without carbohydrate is almost useless to the recipient as a source of biologically active erythrocytes, although it usually does not contain sufficient free hæmoglobin at this time to be actually a source of danger. Dextrin and sucrose, although they delay the onset of hæmolysis in vitro almost as well as glucose, have very little effect in prolonging the in vivo survival of blood. The effect of glucose in prolonging the survival of erythrocytes is very definite, and varies with alterations in the amount and concentration of glucose that is added. When approximately one volume of citrate‐glucose solution is added to four volumes of blood, variation of the concentration of glucose in the final mixture from 0·6 to 2·2 per cent, makes little difference to subsequent survival. If a larger volume of citrate‐glucose solution is added, however, and a final concentration of 2·7 per cent. in the final mixture is attained, survival is very definitely prolonged. Thus, whereas blood stored in the standard citrate‐glucose solution (VI) for periods of 11‐15 days already shows some falling off in survival, blood stored with the Rous‐Turner solution (X) for periods up to 21 days has a survival which is very little inferior to that of fresh blood. Although the Rous‐Turner solution is thus a better preservative than the citrate‐glucose solution in general use, the advantage is not obvious with blood stored for less than 10 days at least. Moreover, the large relative volume of diluent in the Rous‐Turner solution is a definite disadvantage both from the administrative and transfusion points of view. Thus for blood banks i...

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Haemolytic Transfusion Reactions

Klein¹,

Anstee²

2005

Mollison's Blood Transfusion in Clinical Medicine

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Pigment Metabolism after Blood Transfusion

Cited by 14 publications

References 3 publications

Hematin compounds and bile pigments; their constitution, metabolism, and function, by R. Lemberg and J.W. Legge.

Hematin compounds and bile pigments; their constitution, metabolism, and function, by R. Lemberg and J.W. Legge.

IN VIVO SURVIVAL IN THE HUMAN SUBJECT OF TRANSFUSED ERYTHROCYTES AFTER STORAGE IN VARIOUS PRESERVATIVE SOLUTIONS

Haemolytic Transfusion Reactions

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