Pigment Epithelial Detachments with Retinal Vascular Anomalous Complex in Age-Related Macular Degeneration

Abstract

Purpose: To analyze and compare the angiographic features of retinal vascular anomalous complex (RVAC) in patients with a vascularized pigment epithelial detachment (PED) secondary to age-related macular degeneration. Methods: Retrospective evaluation of fluorescein and indocyanine green angiographies of 180 patients with occult choroidal neovascularization and PED. Results: On indocyanine green angiography (ICGA), RVAC demonstrated as a focal hyperfluorescence in connection with retinal choroidal anastomosis was identified in 12 of the 180 eyes (6.7%) with a vascularized PED. In comparison, fluorescein angiography revealed RVAC in 6 of the 12 eyes. Associated clinical and angiographic features were intraretinal hemorrhage in all 12 eyes, cystoid macular edema in 6 eyes and preretinal hemorrhage in 4 eyes. Conclusions: RVAC is better delineated on ICGA than on fluorescein angiography. In clinically suspected cases with a vascularized PED in connection with intraretinal hemorrhage and/or cystoid macular edema, ICGA should be performed to enhance management considerations.

Human Adult Retinal Pigment Epithelial Stem Cell–Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native Tissue

“…There is considerable interest in developing ''disease in a dish'' models of human RPE. 7,8,[89][90][91] Successful maintenance of epithelial polarity and function in vitro has been a long sought goal for studying RPE-related diseases. 32,[92][93][94] In this study, we showed that ahRPE cells isolated and cultured from nhRPE 43 have functional and morphologic characteristics resembling native tissue.…”

Confluent Monolayers of Cultured Human Fetal Retinal Pigment Epithelium Exhibit Morphology and Physiology of Native Tissue

“…In the past decade, there has been an increased interest in RPE function and its role in multiple retinal diseases. [51][52][53][54][55][56] A corollary of this increased interest is the need to develop in vitro cell culture models to study a wide range of RPE physiology and pathophysiology. As in other organ systems, it has been difficult to create RPE cell lines and primary cultures with the appropriate morphologic and structural characteristics.…”

Die Therapie der vaskularisierten serösen Pigmentepithelabhebung bei AMD – Beobachtungen nach Wechsel des intravitrealen Medikamentes bei Therapieversagen

“…Zum einen kçnnen serçse PED mit meist randständiger okkulter CNV assoziiert sein und zum anderen kçnnen sie aber auch Folge einer retinalen angiomatçsen Proliferation (RAP) sein. [35,41]. Bei einer RAP ist klinisch und angiografisch meist im Zentrum der PED lokalisierte Gefäßproliferation erkennbar.…”