Pigment Epithelial Detachment in Polypoidal Choroidal Vasculopathy

Tsujikawa, Akitaka; Sasahara, Manabu; Otani, Atsushi; Gotoh, Noriko; Kameda, Takuro; Iwama, Daisuke; Yodoi, Yuko; Tamura, Hiroshi; Mandai, Michiko; Yoshimura, Nagahisa

doi:10.1016/j.ajo.2006.08.025

Cited by 112 publications

(88 citation statements)

References 30 publications

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“…Our findings were consistent with several previous epidemiological studies where cases of PCV were reported occurrence had a preponderance for male gender (59.3%), unilateral involvement (94.1%) and macular location (86.8%) of the polyps and this was similar to other studies from Asia (Uyama et al 2002;Yannuzzi et al 1994). On the other hand, our findings differ greatly from the white population where PCV is reported to be more common among female patients with bilateral involvement and peripapillary location (Yannuzzi et al 1990;Tsujikawa et al 2007;Ojima et al 2009;Lafaut et al 2000). Important genetic substrate most probably explains the epidemiological similarities between our study population with other Asian populations and the difference observed with the white population.…”

Section: Discussionsupporting

confidence: 88%

“…Subretinal fibrous proliferation causes severe irreversible visual loss due to the disruption of sensory retina and retinal pigment epithelium (RPE). In a study by Tsujikawa et al (2007), PED was observed in 51 eyes (55%), of which Modified from Table 3 in Sho et al and Table 1 in Wong et al 2015 5 were hemorrhagic PED (9.8%) and 46 (90.2%) were serous. In our study, similar findings were observed where 49 eyes were found to have PED (53.8%), 13 eyes had hemorrhagic PED (26.5%) and 36 eyes (73.5%) had serous PED.…”

Section: Discussionmentioning

confidence: 91%

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Patterns of Polypoidal Choroidal Vasculopathy among a Multiracial Population in a Malaysian Hospital

Isa¹

2016

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ABSTRAK Polypoidal choroidal vasculopathy (PCV) adalah penyakit retina yang dicirikan olehand almost all patients (97.7%) had loss of external limiting membrane (ELM) and IS/OS interface. On indocyanine green angiography, majority of eyes had multiple polyps (82.4%) with 'cluster' (58.2%) being the commonest configuration. In conclusion, although the patterns of PCV in UKMMC were mainly similar to other Asian patients, a number of our patients had associated drusen. This indicates that PCV in our population could be a variant of neovascular age related macular degeneration and not solely idiopathic in nature.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 91%

Patterns of Polypoidal Choroidal Vasculopathy among a Multiracial Population in a Malaysian Hospital

Isa¹

2016

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“…18,19 The cluster type of PCV lesions, which was the most common formation of the PCV lesions, was found to be related to increased frequency of massive haemorrhage with poorer visual outcomes. 7,16 Larger PCV size (lesion Z1 disc area) is associated with severe vision-threatening complications, such as suprachoroidal haemorrhage and VH.…”

Section: Discussionmentioning

confidence: 98%

Visual outcomes of vitrectomy for polypoidal choroidal vasculopathy-related breakthrough vitreous haemorrhage

Yang

2014

Eye

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“…2,11,12 In our study, 51% of eyes with PCV presented with any form of PED (haemorrhagic or serous). Tsujikawa et al 11 report a PED frequency of 53% in their study in Japanese patients with PCV.…”

Section: Discussionmentioning

confidence: 97%

“…[11][12][13] Tsujikawa et al 11 showed that the majority of PEDs in PCV were serous. This is, however, in contrast to our study in which the PEDs were predominantly haemorrhagic and were the presenting feature in 45.7% of eyes diagnosed with PCV.…”

Section: Discussionmentioning

confidence: 99%

Haemorrhagic pigment epithelial detachment as a predictive feature of polypoidal choroidal vasculopathy in a Chinese population

Cackett

Htoon

Wong

et al. 2009

Eye

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Purpose To determine the frequency of haemorrhagic pigment epithelial detachment (PED) among patients presenting with either polypoidal choroidal vasculopathy (PCV) or choroidal neovascularization (CNV) and calculate the degree to which the presence of a haemorrhagic PED can be used to predict the diagnosis of PCV. Methods A retrospective review of 290 eyes of 253 patients presenting to the Singapore National Eye Centre with serosanguineous maculopathy. Patients underwent ophthalmologic examination including digital colour fundus photography and stereoscopic fluorescein angiography and indocyanine green angiography (ICGA). Classification into PCV or CNV was based on ICGA findings, and presence or absence of haemorrhagic PED was documented. Results In total, 138 eyes of 123 patients were diagnosed with PCV and 152 eyes of 130 patients with CNV. A haemorrhagic PED was a significantly more common (Po0.001) presenting feature in PCV eyes (63, 45.7%) than CNV eyes (6, 3.9%) (odds ratio (OR) 20.4, 95% confidence interval (CI) 8.5-49.4). Age-related maculopathy was found significantly more frequently (Po0.001) in the unaffected fellow eye of CNV patients (57, 52.8%) than PCV patients (28, 22.8%) (OR 3.2, 95% CI 1.8-5.7). Conclusions In patients of Chinese ethnicity, a haemorrhagic PED is significantly more likely to be the presenting feature of PCV than CNV. Patients presenting with this clinical feature should make the clinician suspicious of an underlying diagnosis of PCV.

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Pigment Epithelial Detachment in Polypoidal Choroidal Vasculopathy

Cited by 112 publications

References 30 publications

Patterns of Polypoidal Choroidal Vasculopathy among a Multiracial Population in a Malaysian Hospital

Patterns of Polypoidal Choroidal Vasculopathy among a Multiracial Population in a Malaysian Hospital

Visual outcomes of vitrectomy for polypoidal choroidal vasculopathy-related breakthrough vitreous haemorrhage

Haemorrhagic pigment epithelial detachment as a predictive feature of polypoidal choroidal vasculopathy in a Chinese population

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