Pigment Dispersion Syndrome and Pigmentary Glaucoma

Garg, Ashok

doi:10.5005/jp/books/10502_57

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“…[6] Zentmayer first described a ring of pigments on the posterior capsule of the lens, later known as Zentmayer's line [7] or Scheie's and Cameron stripe [8] and the pigmentation of the Schwalbe's line is known as Sampaolesi line. [9] Initially thought to be a very rare disease, the prevalence of PDS has increased, due to better diagnostic capabilities and increased awareness, with demographic studies helping us to understand it's distribution. ere is, however, a paucity of literature on the prevalence and demographic distribution of PDS in the Indian population.…”

Section: Introductionmentioning

confidence: 99%

Clinical profile and demographic distribution of pigment dispersion syndrome: An electronic medical record-driven big data analytics from an eye care network in India

Warjri

Das

Senthil

2023

LAJO

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Objectives: The purpose of this study was to describe the demographics and clinical profile of pigment dispersion syndrome (PDS) in patients presenting to a multi-tier ophthalmology hospital network in India. Material and Methods: This cross-sectional hospital-based study included 2,961,706 new patients presenting between August 2010 and September 2021. Patients with a clinical diagnosis of PDS in at least one eye were included as cases. The data were collected using an electronic medical record system. Results: Overall, 403 (0.014%) patients were diagnosed with PDS. Three fourth of the patients were male (75.43%) and 91.81% had bilateral affliction. The most common age group at presentation was during the fourth decade of life with 100 (24.81%) patients. In the 773 eyes, 443 (57.31%) eyes had mild or no visual impairment (<20/70) and blindness (>20/400) in 81 (10.48%) eyes. Krukenberg spindle was seen in 445 (57.57%) eyes and iris transillumination defects in 33 (4.27%) eyes. About a third of the eyes, 241 (31.18%) eyes had an intraocular pressure (IOP) >21 mm of Hg at presentation. Three hundred and twenty-eight (42.43%) eyes were on more than one anti-glaucoma medication. YAG peripheral iridotomy was documented in 100 (12.94%) eyes. In the 46 (5.95%) eyes that required a glaucoma related surgical intervention, combined surgery was performed in 30 (3.88%) eyes and trabeculectomy in 16 (2.07%) eyes. Conclusion: PDS is more common in males presenting during the fourth decade of life and is predominantly bilateral. A third of the eyes have raised IOP and a tenth of them are affected with blindness at presentation.

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