Piglet anaemia

Venn, J.; Davies, E.

doi:10.1136/vr.77.35.1004

Cited by 3 publications

(2 citation statements)

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“…As an important example, iron deficiency, which is one of the most common nutritional defects during the neonatal period in mammals [12, 13], is extremely common in swine, due to the high reproductive performance required of these animals. Unless given iron supplements, piglets may develop iron-deficiency a few days after birth [14, 15]. This condition occurs regardless of the breed and management system, and is the result of interactions of several factors including low levels of iron stores, increased requirements, poor exogenous supply and immaturity of absorption mechanisms [15, 16].…”

Section: Introductionmentioning

confidence: 99%

The biomedical piglet: establishing reference intervals for haematology and clinical chemistry parameters of two age groups with and without iron supplementation

et al. 2016

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BackgroundThe similarities between swine and humans in physiological and genomic patterns, and the great correlation in size and anatomy, make pigs extremely useful in preclinical studies. New-born piglets can represent a model for congenital and genetic diseases in new-born children. It is known that piglets may have significant differences in clinicopathological results compared to adult pigs. Therefore, adult laboratory reference intervals cannot be applied to piglets. The aim of this study was to compare haematological and chemical variables in piglets of two ages and determinate age-related reference intervals for commercial hybrid young pigs.Blood samples were collected under general anaesthesia from 130 animals divided into five- (P5) and 30- (P30) day-old piglets. Only P30 animals were treated with parenteral iron after birth. Samples were analysed using automated haematology (ADVIA 2120) and chemistry analysers, and age-related reference intervals were calculated.ResultsSignificant higher values of RBC, Hb and HCT were observed in P30 animals when compared to P5, with an opposite trend for MCV. These results were associated with a reduction of the RBC regeneration process and the thrombopoietic response. The TSAT and TIBC were significantly higher in P30 compared to P5; however, piglets remained iron deficient compared to adult reference intervals reported previously.ConclusionsIn conclusion, this paper emphasises the high variability occurring in clinicopathological variables between new-born and 30-day-old pigs, and between piglets and adult pigs. This study provides valuable reference data for piglets at precise ages and could be used in the future as historical control improving the Reduction in animal experiments, as suggested by the 3Rs principle.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-017-0946-2) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

The biomedical piglet: establishing reference intervals for haematology and clinical chemistry parameters of two age groups with and without iron supplementation

et al. 2016

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“…Iron deficiency anaemia (IDA) is the most commonly recognised clinical condition of fast‐growing piglets reared under intensive conditions and is considered as an emerging problem in modern swine production 1. IDA develops in piglets which do not receive iron supplementation, which is due to various factors, including the low body iron reserves at birth, the low iron content of the sow's milk,2 3 the rapid growth rate of the newborn piglet with its high requirement for a large amount of haemoglobin‐carrying red blood cells4 and limited access to soil as an iron source 5 6. These factors result in a predictable drop in haemoglobin and other iron‐carrying molecules in the piglets’ blood, and IDA inevitably develops unless supplemental bioavailable iron is administered shortly after birth.…”

Section: Introductionmentioning

confidence: 99%

Comparative efficacy of two parenteral iron‐containing preparations, iron gleptoferron and iron dextran, for the prevention of anaemia in suckling piglets

Šperling

Freudenschuss

Shrestha³

et al. 2018

Veterinary Record Open

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Iron-deficiency anaemia (IDA) is a serious health problem in neonatal piglets and is controlled by routine application of iron in various formulations. The efficacy and safety of two iron-containing products for the prevention of IDA in suckling piglets were compared in a randomised, parallel study. Newborn piglets were treated with 200 mg iron supplied by intramuscular injection in the neck as either Forceris (gleptoferron; n=13) or Uniferon 200 (iron dextran; n=12) 24–48 hours after birth. Blood samples were collected before and after treatment (2nd, 18th and 31st day of life) for complete haematology. The treatments were well tolerated with only mild transient swelling observed in two piglets (Forceris group). Piglets treated with Forceris had significantly higher haemoglobin, haematocrit, mean corpuscular volume and haemoglobin concentration values, as well as significantly higher plasma iron and transferritin saturation and a lower total iron binding capacity than those treated with Uniferon. No animals in the Forceris group but 17 per cent of piglets in the Uniferon group had haemoglobin levels <9 g/dl after treatment, indicating anaemia. These results suggest that both products were safe and effective in the prophylaxis of IDA in piglets, and that Forceris was superior to Uniferon in preventing IDA in piglets.

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Welfare and production implications of teeth clipping and iron injection of piglets in outdoor systems in Scotland

Brown¹,

Edwards²,

Smith³

et al. 1996

Preventive Veterinary Medicine

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Piglet anaemia

Cited by 3 publications

References 0 publications

The biomedical piglet: establishing reference intervals for haematology and clinical chemistry parameters of two age groups with and without iron supplementation

The biomedical piglet: establishing reference intervals for haematology and clinical chemistry parameters of two age groups with and without iron supplementation

Comparative efficacy of two parenteral iron‐containing preparations, iron gleptoferron and iron dextran, for the prevention of anaemia in suckling piglets

Welfare and production implications of teeth clipping and iron injection of piglets in outdoor systems in Scotland

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