Silver nanoparticles (AgNPs) are
broad-spectrum antibacterial
agents
that are safe for the environment and the human body. To achieve a
balance between material functionality, degradability, and safety
of AgNPs, the peanut red skin (PSE)/polyphenol-hydroxypropyl-β-cyclodextrin
(HPβCD)/AgNPs were prepared for the first time by ultrasound-triggered
molecular encapsulation and biosynthesis for hydrophilic fusion of
medicine and small molecules. Additionally, a novel “controlled
release” sodium alginate (SA)-based hydrogel was developed
and medicine/small-molecule self-assembled PSE/HPβCD/AgNPs were
introduced into the three-dimensional network structure of the SA
hydrogels. The SA-based hydrogels exhibited excellent mechanical and
rheological properties. In different pH conditions, the hydrogels
exhibit differing release and expansion behaviors, and the maximum
cumulative release of AgNPs was 98.21% at pH > 6.8. Furthermore,
the
hydrogels exhibited strong antibacterial effects against pathogenic
bacteria. They also showed excellent antioxidant properties and cytocompatibility.
These advantages highlight the potential utility of the developed
hydrogels for biomedical applications and agricultural fields.