Pig plasma postalbumin-2 (α1B-Glycoprotein): isolation, partial characterization and immunological cross-reactivity with other mammalian sera

Stratil, A.; Gahne, B.; Juneja, Rajnish; Spik, G

doi:10.1016/0305-0491(87)90270-7

Cited by 8 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This clearly indicates that pig P02, horse Xk and dog Pa plasma proteins are the homologues of human plasma a l B in these species. These conclusions are collaborated by the following: (1) horse Xk, dog Pa and human a l B proteins cross-reacted with antiserum to pig PO2 (Stratil et al 1986; our unpublished results); and (2) the amino acid and carbohydrate compositions of human a l B (revised values given recently by Ishioka et al 1986) are very similar to those of pig PO2 (Stratil et al1987).…”

Section: Resultsmentioning

confidence: 55%

“…Recently, Lalley & McKusick (1985) suggested that homologous proteins and their loci should be assigned identical symbols in different species so as to facilitate comparative gene mapping. The protein symbol of human plasma alB-glycoprotein is alB (Ishioka et al 1986) and its locus symbol was designated A l B (Gahne et al 1987). We thus propose here that pig P02, horse Xk and dog Pa plasma proteins be redesignated alB-glycoprotein (alB) with locus symbol AI B.…”

Section: Postalbumin Of Pigs Horses and Dogs Identzjied As Alb 123mentioning

confidence: 99%

“…Genetic polymorphism of human plasma a l B has scarcely been studied and has been described in only one report (Altland et al 1983;also in Altland & Hacklar 1984). A more detailed description of the genetic polymorphism of human plasma a1B was recently reported by Gahne et al (1987).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polymorphic plasma postalbumins of some domestic animals (pig PO2, horse Xk and dog Pa proteins) identified as homologous to human plasma α₁B‐glycoprotein

1987

View full text Add to dashboard Cite

Pig, horse and dog plasma proteins, separated by horizontal polyacrylamide gel electrophoresis (pH 9.0) and electrophoretically transferred to nitrocellulose membranes, were tested for cross-reaction with antiserum to human plasma alB-glycoprotein (alB). The results showed that one previously reported polymorphic plasma postalbumin in each of these species (pig P02, horse Xk and dog Pa protein) was homologous to human plasma alB. In the light of the previously known genetic linkages in these species, this implied: (1) alB gene is close linked to Phi, Pgd and Hal (halothane sensitivity locus) loci in pigs; and (2) alB gene is linked to ME1 and Phi loci in horses. This suggested that the alB gene may also be found to be closely linked to gene(s) controlling susceptibility to malignant hyperthermia in humans and other mammals.

show abstract

Section: Resultsmentioning

confidence: 55%

Section: Postalbumin Of Pigs Horses and Dogs Identzjied As Alb 123mentioning

confidence: 99%

See 1 more Smart Citation

Polymorphic plasma postalbumins of some domestic animals (pig PO2, horse Xk and dog Pa proteins) identified as homologous to human plasma α₁B‐glycoprotein

1987

View full text Add to dashboard Cite

show abstract

“…However, our investigations indicate dominance and overdominance of marker‐heterozygotes always in unfavourable direction. A1BG belongs most likely to the immunoglobuline like supergene family (S tratil et al 1987) and hence it is not related with passage of creatine kinase from muscle cells into blood. PGD enzymes are usually present in physiological excess (H arris 1980).…”

Section: Methodsmentioning

confidence: 99%

Associations between blood marker loci and stress susceptibility in pigs

Ruß¹,

Duda²,

Pirchner³

1992

J Animal Breeding Genetics

View full text Add to dashboard Cite

Summary Associations between blood marker and stress susceptibility in pigs as indicated by halothane reaction and log CK‐activity are characterized in three selection lines (DLM, DLK, Pietrain). Strong linkage disequilibria varying in direction and extent between the lines were found in DLK and DLM, but not for Pietrain. Thus, A1BSS is associated with about 75% of the Hallnn genotypes in the DLK and PGDBB with about 89% of these in the DLM. The GPI‐system appeared not to be suitable for marker analysis. Application of markers to selection of stress resistant animals is more efficient since no positive reagents and only 1% heterozygous animals are found in the A1BFF/PGDAA‐genotype combinatin. Combining marker alleles to haplotypes is superior in accuracy and efficiency to the use of marker genotypes for identification of halothane genotypes. Gene effects of marker‐ and halothane loci on log CK‐activity have been estimated. Independent of the dominating influence of Haln (a = 0.6) marker alleles A1BF and PGDB affect CK‐activity desirably by additive and epistatic gene effects. Linkage with an other loci might be considered as cause of this. Zusammenfassung Zusammenhänge zwischen Blutmarkersystemen und Streßanfälligkeit bei Schweinen Die Zusammenhänge zwischen Blutmarkersystemen und Streßanfälligkeit beim Schwein, die durch Halothangenotypen und log CK‐Aktivität repräsentiert wird, wurden in drei Schweineselektionslinien (DLK, DLM, Pietrain) festgestellt. Während in der Pietrainlinie keine Zusammenhänge zu finden sind, wurden Kopplungsungleichgewichte zwischen Marker‐ und Halothangenotypen bei DL gefunden, die jedoch in Ausmaß und Richtung zwischen den Linien differieren. Mit Hilfe von A1BSS könnten etwa 75% der Halnn‐Genotypen in der DLK und mit PGDBB 89% in der DLM erfaßt werden. Das GPI‐System erwies sich als unbrauchbar zur Anwendung bei markergestützten Selektionsmaßnahmen. Die Marker würden sich wesentlich besser zur Selektion von homozygot resistenten Tieren eignen, da in der A1BFF/PGDAA Genotypenkombination keine halothan‐positive und nur etwa 1% halothan‐heterozygote Tiere zu finden sind. Die Verknüpfung von Markerallelen zu Haplotypen ist geeigneter zur Bestimmung der Halothangenotypen. Durch Trennung von Marker‐ und Halothangenotypeffekten konnten Geneffekte auf die log CK‐Aktivität geschätzt werden. Unabhängig von der dominierend erhöhenden Wirkung durch Haln (a = 0.6), beeinflussen die Markergenotypen A1BF und PGDA die CK‐Aktivität im züchterisch positiven Sinn mit additiven und epistatischen Genwirkungen. Als Ursache wurde Kopplung mit einem weiteren Locus der Synthäniegruppe für möglich erachtet.

show abstract

“…The rabbit Prt protein of Juneja et al was identified to be homologous to human and pig serum cwlB glycoprotein (AlBG) (Stratil et al 1987). In view of the fact that in the pig the A l B G locus (previously P02) is closely linked to the PGD (6-phosphogluconate dehydrogenase) locus (Juneja et al 1983;Gahne & Juneja 1985) we studied linkage relationship between the two homologous loci (i.e.…”

mentioning

confidence: 99%

Absence of genetic linkage between A1BG, PGD and HPX loci in rabbits

Stratil¹,

Gábrisová

Ĉizova

et al. 1991

Animal Genetics

View full text Add to dashboard Cite

show abstract

Pig plasma postalbumin-2 (α1B-Glycoprotein): isolation, partial characterization and immunological cross-reactivity with other mammalian sera

Cited by 8 publications

References 15 publications

Polymorphic plasma postalbumins of some domestic animals (pig PO2, horse Xk and dog Pa proteins) identified as homologous to human plasma α₁B‐glycoprotein

Polymorphic plasma postalbumins of some domestic animals (pig PO2, horse Xk and dog Pa proteins) identified as homologous to human plasma α₁B‐glycoprotein

Associations between blood marker loci and stress susceptibility in pigs

Absence of genetic linkage between A1BG, PGD and HPX loci in rabbits

Contact Info

Product

Resources

About

Pig plasma postalbumin-2 (α1B-Glycoprotein): isolation, partial characterization and immunological cross-reactivity with other mammalian sera

Cited by 8 publications

References 15 publications

Polymorphic plasma postalbumins of some domestic animals (pig PO2, horse Xk and dog Pa proteins) identified as homologous to human plasma α1B‐glycoprotein

Polymorphic plasma postalbumins of some domestic animals (pig PO2, horse Xk and dog Pa proteins) identified as homologous to human plasma α1B‐glycoprotein

Associations between blood marker loci and stress susceptibility in pigs

Absence of genetic linkage between A1BG, PGD and HPX loci in rabbits

Contact Info

Product

Resources

About

Polymorphic plasma postalbumins of some domestic animals (pig PO2, horse Xk and dog Pa proteins) identified as homologous to human plasma α₁B‐glycoprotein

Polymorphic plasma postalbumins of some domestic animals (pig PO2, horse Xk and dog Pa proteins) identified as homologous to human plasma α₁B‐glycoprotein