Piezoresistivity in single DNA molecules

Bruot, Christopher; Palma, Julio L.; Xiang, Limin; Mújica, Vladimiro; Ratner, Mark A.; Tao, Nongjian

doi:10.1038/ncomms9032

Cited by 38 publications

(26 citation statements)

References 40 publications

(61 reference statements)

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“…Particularly, in DNA molecules, an intermediate coherent-incoherent (ICI) situation is expected to be promoted if partial delocalization of charges beyond a single G base could be managed. Indeed, recent measurements of charge transport in double-stranded DNA molecules suspended between electrodes have revealed an interesting ICI transport regime 1, 19 : In an alternating (GC) n sequence the resistance increased linearly with length, consistent with the picture of incoherent charge hopping between the G sites. In contrast, sequences of two segments of G bases, G n C n , showed linear enhancement with n dressed by periodic oscillation, suggesting that charges were partially delocalized within stacked-G segments 1 .…”

Section: Introductionmentioning

confidence: 83%

Intermediate Coherent–Incoherent Charge Transport: DNA as a Case Study

2016

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We study an intermediate quantum coherent-incoherent charge transport mechanism in metal-molecule-metal junctions using Büttiker's probe technique. This tool allows us to include incoherent effects in a controlled manner, and thus to study situations in which partial decoherence affects charge transfer dynamics. Motivated by recent experiments on intermediate coherent-incoherent charge conduction in DNA molecules [L. Xiang et al., Nature Chem. 7, 221-226 (2015)], we focus on two representative structures: alternating (GC) n and stacked G n C n sequences; the latter structure is argued to support charge delocalization within G segments, and thus an intermediate coherent-incoherent conduction. We begin our analysis with a highly simplified 1-dimensional tight-binding model, while introducing environmental effects through Büttiker's probes. This minimal model allows us to gain fundamental understanding of transport mechanisms and derive analytic results for molecular resistance in different limits. We then use a more detailed ladder-model Hamiltonian to represent double-stranded DNA structures-with environmental effects captured by Büttiker's probes. We find that hopping conduction dominates in alternating sequences, while in stacked sequences charge delocalization (visualized directly through the electronic density matrix) supports significant resonant-ballistic charge dynamics reflected by an even-odd effect and a weak distance dependence for resistance. Our analysis illustrates that lessons learned from minimal models are helpful for interpreting charge dynamics in DNA.

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Section: Introductionmentioning

confidence: 83%

Intermediate Coherent–Incoherent Charge Transport: DNA as a Case Study

2016

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“…In a related study, they compared the critical stretching length (the length at which the conduction jump occurs) of various closed-end and free end DNA systems. 29 Tao et al 30 also studied the molecular conductance and piezoresistivity of dsDNA for various lengths and sequences. In a very recent study, Artés et al 31 reported the increase in conductance of the DNA during its conformational change from B to A form.…”

Section: Introductionmentioning

confidence: 99%

Dramatic changes in DNA conductance with stretching: structural polymorphism at a critical extension

et al. 2016

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aIn order to interpret recent experimental studies of the dependence of conductance of ds-DNA as the DNA is pulled from the 3'end1-3'end2 ends, which find a sharp conductance jump for a very short (4.5%) stretching length, we carried out multiscale modeling to predict the conductance of dsDNA as it is mechanically stretched to promote various structural polymorphisms. We calculate the current along the stretched DNA using a combination of molecular dynamics simulations, non-equilibrium pulling simulations, quantum mechanics calculations, and kinetic Monte Carlo simulations. For 5'end1-5'end2 attachments we find an abrupt jump in the current within a very short stretching length (6 Å or 17%) leading to a melted DNA state. In contrast, for 3'end1-3'end2 pulling it takes almost 32 Å (84%) of stretching to cause a similar jump in the current. Thus, we demonstrate that charge transport in DNA can occur over stretching lengths of several nanometers. We find that this unexpected behaviour in the B to S conformational DNA transition arises from highly inclined base pair geometries that result from this pulling protocol. We found that the dramatically different conductance behaviors for two different pulling protocols arise from how the hydrogen bonds of DNA base pairs break.

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“…图 1 研究者选用的双链 DNA 分子的示意图 [50] Figure 1 Schematics of the six dsDNA molecules selected by the researchers [50] 压电效应是材料的一种基本性能, 在许多器件的设计和制备中得到了广泛应用. 2015 年, Bruot 等 [51] [51] Figure 2 (a) A typical current-distance trace recorded in experiment. The plateau indicates a stable molecular junction was established between the tip and substrate; (b) Schematic of the modified STM-BJ setup with a modulating tip; (c) The evolution of amplitude of conductance modulation with time as the junction was mechanically modulated [51] 2017 年, Harashima 等 [52] 基于 STM-BJ 技术, 发现了通过调控碱基对之间的 π-π 堆积作用, 可以实现对 DNA 分子的电导调控.…”

Section: 扫描隧道显微镜裂结法mentioning

confidence: 99%

Advances in Charge Transport through DNA Molecular Junction by Employing Electrodes Pair with Nanometer-sized Separation

Yang¹,

Lei²,

Hong³

et al. 2019

Acta Chim. Sinica

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Molecular electronics is an interdisciplinary science that mainly studies the charge transport through molecules and its main goal is to fabricate molecular devices with electrical functionalities. In the state-of-art of molecular electronics, the research paradigm is to fabricate electrodes pair with nanometer-sized separation and construct the molecular junction through the assembly of target molecules with the electrodes pair. With this framework, the target molecule can be integrated to the macroscopic measurement circuit. DNA is one of the most significant biomolecules in natural sciences. It had drawn great attentions in biomedicine because of the carried genetic instructions. In molecular electronics, DNA also had attracted much interest due to the distinct structure and its capability of long-range charge transport. Nevertheless, in the early stage of molecular electronics, the probe molecules were limited to those with simple structures and short lengths. In recent years, molecular electronics had witnessed a rapid progress due to the developments in micro/nano-fabrication and the detection for weak current signal. Specifically, it includes the improvements in the success rate, efficiency, and stability of the fabricated molecular device. Benefiting from that, the probe molecules had been extended to a number of complex compounds like DNA. We give a brief introduction to the recent progress in the fabrication of DNA molecular junctions and the studies on the corresponding charge transport, most of which were made by using the research paradigm of fabricating electrodes pair with nanometer-sized separation. According to the fabrication methods that employed, these advances were introduced in two classes. One is that made by the as-called break junction methods, which include STM-break junction, conductive AFM and mechanically controllable break junction. The other is that made by the as-called cutting methods, which include cutting of carbon nanotube, graphene and silicon nanowire. We summarize the historical development of these methods and give a comparison between them. We also introduce some representative research on the charge transport through DNA molecular junction, and discuss the distinct features of DNA in electrical properties compared to the conventional small molecules. To conclude, we give a prospect on the future development of the studies on charge transport through DNA molecular junction.

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Piezoresistivity in single DNA molecules

Cited by 38 publications

References 40 publications

Intermediate Coherent–Incoherent Charge Transport: DNA as a Case Study

Intermediate Coherent–Incoherent Charge Transport: DNA as a Case Study

Dramatic changes in DNA conductance with stretching: structural polymorphism at a critical extension

Advances in Charge Transport through DNA Molecular Junction by Employing Electrodes Pair with Nanometer-sized Separation

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