Abstract:An accurate analytical model for the change in resistance of a piezoresistor is necessary for the design of silicon piezoresistive transducers. Ion implantation requires a high-temperature oxidation or annealing process to activate the dopant atoms, and this treatment results in a distorted dopant profile due to diffusion. Existing analytical models do not account for the concentration dependence of piezoresistance and are not accurate for nonuniform dopant profiles. We extend previous analytical work by intro… Show more
“…For tracking and targeting, we built on systems reported by Leifer et al 8 and Stirman et al 26 , who implemented real-time tracking for delivering optical stimuli to user-defined body segments ( Figure 1). For mechanical stimulus delivery, we relied on our previous system consisting of a custom, self-sensing, cantilever force probe [18][19][20] integrated into a closed loop control system 16 . HAWK introduces the ability to automatically measure and classify behavioral responses.…”
Section: Hawk System Designmentioning
confidence: 99%
“…Central to the function of HAWK are two key, custom innovations: 1) a custom-force sensing cantilever that acts as the stimulator [15][16][17] and 2) an optical system to track and target the animal. The detailed design, fabrication and signal conditioning of these silicon, piezeoresistive cantilevers were previously reported [18][19][20] . We present the design of the optical system here.…”
Sensory neurons embedded in skin are responsible for the sense of touch. In humans and other mammals, touch sensation depends on thousands of diverse somatosensory neurons. By contrast, Caenorhabditis elegans nematodes have six gentle touch receptor neurons linked to simple behaviors. The classical touch assay uses an eyebrow hair to stimulate freely moving C. elegans, evoking evasive behavioral responses.While this assay has led to the discovery of genes required for touch sensation, it does not provide control over stimulus strength or position. Here, we present an integrated system for performing automated, quantitative touch assays that circumvents these limitations and incorporates automated measurements of behavioral responses. Highly Automated Worm Kicker (HAWK) unites microfabricated silicon force sensors and video analysis with real-time force and position control. Using this system, we stimulated animals along the anterior-posterior axis and compared responses in wild-type and spc-1(dn) transgenic animals, which have a touch defect due to expression of a dominant-negative a spectrin protein fragment.As expected from prior studies, delivering large stimuli anterior to the mid-point of the body evoked a reversal, but such a stimulus applied posterior to the mid-point evoked a speed-up. The probability of evoking a response of either kind depended on stimulus strength and location; once initiated, the magnitude and quality of both reversal and speed-up behavioral responses were uncorrelated with stimulus location, strength, or the absence or presence of the spc-1(dn) transgene. Wild-type animals failed to respond when the stimulus was applied near the mid-point. These results establish that stimulus strength and location govern the activation of a stereotyped motor program and that the C. elegans body surface consists of two receptive fields separated by a gap.
“…For tracking and targeting, we built on systems reported by Leifer et al 8 and Stirman et al 26 , who implemented real-time tracking for delivering optical stimuli to user-defined body segments ( Figure 1). For mechanical stimulus delivery, we relied on our previous system consisting of a custom, self-sensing, cantilever force probe [18][19][20] integrated into a closed loop control system 16 . HAWK introduces the ability to automatically measure and classify behavioral responses.…”
Section: Hawk System Designmentioning
confidence: 99%
“…Central to the function of HAWK are two key, custom innovations: 1) a custom-force sensing cantilever that acts as the stimulator [15][16][17] and 2) an optical system to track and target the animal. The detailed design, fabrication and signal conditioning of these silicon, piezeoresistive cantilevers were previously reported [18][19][20] . We present the design of the optical system here.…”
Sensory neurons embedded in skin are responsible for the sense of touch. In humans and other mammals, touch sensation depends on thousands of diverse somatosensory neurons. By contrast, Caenorhabditis elegans nematodes have six gentle touch receptor neurons linked to simple behaviors. The classical touch assay uses an eyebrow hair to stimulate freely moving C. elegans, evoking evasive behavioral responses.While this assay has led to the discovery of genes required for touch sensation, it does not provide control over stimulus strength or position. Here, we present an integrated system for performing automated, quantitative touch assays that circumvents these limitations and incorporates automated measurements of behavioral responses. Highly Automated Worm Kicker (HAWK) unites microfabricated silicon force sensors and video analysis with real-time force and position control. Using this system, we stimulated animals along the anterior-posterior axis and compared responses in wild-type and spc-1(dn) transgenic animals, which have a touch defect due to expression of a dominant-negative a spectrin protein fragment.As expected from prior studies, delivering large stimuli anterior to the mid-point of the body evoked a reversal, but such a stimulus applied posterior to the mid-point evoked a speed-up. The probability of evoking a response of either kind depended on stimulus strength and location; once initiated, the magnitude and quality of both reversal and speed-up behavioral responses were uncorrelated with stimulus location, strength, or the absence or presence of the spc-1(dn) transgene. Wild-type animals failed to respond when the stimulus was applied near the mid-point. These results establish that stimulus strength and location govern the activation of a stereotyped motor program and that the C. elegans body surface consists of two receptive fields separated by a gap.
“…2a. Theoretically, the longitudinal stress σ L in the [110] direction can be calculated using the following expression (Park et al, 2010):…”
Section: Design and Simulationmentioning
confidence: 99%
“…(1) the geometrical factors of the beam are given by the beam length l, width w and thickness t (Park et al, 2010). Subject to material properties, the stress σ L can be described as a product of the elastic modulus E and the longitudinal strain ε L along the x axis.…”
Abstract.A developed transferable micro force sensor was evaluated by comparing its response with an industrially manufactured device. In order to pre-identify sensor properties, three-dimensional (3-D) sensor models were simulated with a vertically applied force up to 1000 µN. Then, controllable batch fabrication was performed by alternately utilizing inductively coupled plasma (ICP) reactive ion etching (RIE) and photolithography. The assessments of sensor performance were based on sensor linearity, stiffness and sensitivity. Analysis of the device properties revealed that combination of a modest stiffness value (i.e., (8.19 ± 0.07) N m −1 ) and high sensitivity (i.e., (15.34 ± 0.14) V N −1 ) at different probing position can be realized using a meander-spring configuration. Furthermore, lower noise voltage is obtained using a double-layer silicon on insulator (DL-SOI) as basic material to ensure high reliability and an excellent performance of the sensor.
“…For the more general case other models are available which include issues such as non-uniform doping of the piezoresistors. 20,21 A. Spring constant: cantilever mechanical model…”
Validation of a technological process requires an intensive characterization of the performance of the resulting devices, circuits, or systems. The technology for the fabrication of micro and nanoelectromechanical systems (MEMS and NEMS) is evolving rapidly, with new kind of device concepts for applications like sensing or harvesting are being proposed and demonstrated. However, the characterization tools and methods for these new devices are still not fully developed. Here, we present an on-wafer, highly precise, and rapid characterization method to measure the mechanical, electrical, and electromechanical properties of piezoresistive cantilevers. The setup is based on a combination of probe-card and atomic force microscopy technology, it allows accessing many devices across a wafer and it can be applied to a broad range of MEMS and NEMS. Using this setup we have characterized the performance of multiple submicron thick piezoresistive cantilever force sensors. For the best design we have obtained a force sensitivity ℜF = 158μV/nN, a noise of 5.8 μV (1 Hz–1 kHz) and a minimum detectable force of 37 pN with a relative standard deviation of σr ≈ 8%. This small value of σr, together with a high fabrication yield >95%, validates our fabrication technology. These devices are intended to be used as bio-molecular detectors for the measurement of intermolecular forces between ligand and receptor molecule pairs.
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