Piezomaterials for bone regeneration design—homogenization approach

Magnesium with micro-arc oxidation coating and polymeric membrane: an in vitro study on microenvironment

“…*P \ 0.05, compared with uncoated sample; #P \ 0.05, compared with MAO-coated sample excellent bioactivity of composite scaffolds of polyhydroxybutyrate-polyhydroxyvalerate (PHBV) with bioactive wollastonite in their immerse testing. PHB offers several advantages over other degradable materials in that its slow degradation is eminently more suitable for long term healing, and its super piezoelectric characteristics [14,15] may stimulate and induce the proliferation, differentiation and growth of cells such as osteocytes [16]. Although our in vitro results suggest that an additionally deposited PHB membrane may be potentially advantageous in future clinical use, long-term in-vivo studies are required to further validate the use of polymer-coated implants for orthopaedic implants.…”

“…MAO is a relatively convenient and effective surface modification technique because it can generate porous, relatively rough and firmly adherent MAO coating on Mg-based materials [12,13]. On the other hand, as a biodegradable polymer, PHB has a relatively low degradation rate and super piezoelectric characteristics [14,15] that stimulate and induce the proliferation, differentiation and growth of cells, such as osteocyte [16].…”

Manufacture and Cytotoxicity of a Lead‐free Piezoelectric Ceramic as a Bone Substitute—Consolidation of Porous Lithium Sodium Potassium Niobate by Cold Isostatic Pressing

“…Studies have shown that alkaline niobate is able to enhance the deposition of hydroxyapatite and formation of a mineralized matrix (Wang, 2006). Furthermore, based on the homogenization theory, a "smart system" consisting of an inert perforated piezoelectric matrix filled with living osteoblasts may help the process of bone regeneration (Miara et al, 2005).…”

Homogenization of thin piezoelectric perforated shells

“…Having in mind such applications as [21] (which presents a piezoelectric porous electrode used as a spatial filter sensor) or [19] (which presents a bio-material made of a piezoelectric matrix with elastic inclusions of osteoblasts and used as a micro device supposed to improve the bone regeneration) our purpose in this paper is to combine the different previous features: shell structure, perforations and piezoelectric model to mathematically analyze a well adapted model. Hence we study the homogenization of a thin shell having periodically distributed microstructures with small size ε, each microstructure containing a hole.…”

“…Finally, in Section 4, we use the operator T ε as a tool to establish the strong convergence of the three covariant components of the displacement field and of the electric potential (Eq. (19)) and therefore to obtain the limit model (Eq. (34)); moreover a strong convergence is established for the correctors (Eq.…”