Piezoelectric PU/PVDF electrospun scaffolds for wound healing applications

Guo, Hongfeng; Li, Zhensheng; Dong, Shiwu; Chen, Weijun; Deng, Ling; Wang, Yufei; Ying, Dajun

doi:10.1016/j.colsurfb.2012.03.014

Cited by 221 publications

(169 citation statements)

References 33 publications

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“…Previous studies have shown that electroactive polymers, in particular piezoelectric poly(vinylidene fluoride) (PVDF), are suitable for the development of electro-mechanically bioactive supports [15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Different techniques have been used to process PVDF and its polymer/composites based in different strategies (Table 1) to obtain various morphologies including micropillars [21], particles [20,22], films [23][24][25] and fibers [15,[26][27][28][29][30][31] in order to better suit specific tissue engineering strategies. Further, it has been shown that substrates based on PVDF have different influence on cell adhesion, proliferation and differentiation [7] depending on their morphology.…”

Section: Introductionmentioning

confidence: 99%

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Strategies for the development of three dimensional scaffolds from piezoelectric poly(vinylidene fluoride)

et al. 2016

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Cell supports based on electroactive materials, that generate electrical signal variations as a response to mechanical deformations and vice-versa, are gaining increasing attention for tissue engineering applications. In particular, poly(vinylidene fluoride), PVDF, has been proven to be suitable for these applications in the form of films and two-dimensional membranes. In this work, several strategies have been implemented in order to develop PVDF three-dimensional scaffolds. Three processing methods, including solvent casting with particulate leaching and three-dimensional nylon, and freeze extraction with poly(vinyl alcohol) templates are presented in order to obtain three-dimensional scaffolds with different architectures and interconnected porosity. Further, it is shown that the scaffolds are in the electroactive β-phase and show a crystallinity degree of ~ 45%. Finally, quasi-static mechanical measurements showed that an increase of the porous size within the scaffold leads to a tensile strengths and the Young's modulus decrease, allowing tuning scaffold properties for specific tissues.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Strategies for the development of three dimensional scaffolds from piezoelectric poly(vinylidene fluoride)

et al. 2016

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“…Due to these intrinsic properties of PVDF, along with the advantages offered by the electrospun fibrous structures such as the high surface area and the flexibility in surface functionalities [16], electrospun PVDF mats have been applied in a wide range of applications [3], either as PVDF alone or with the incorporation of nano-sized fillers [17][18][19][20][21][22][23][24]. Wound healing patches [17], energy harvesting devices [18], electrolyte for lithium-ion batteries [19,20], and superhydrophobic surfaces for different purposes [3,21] are a few examples.…”

Section: Introductionmentioning

confidence: 99%

Designing electrospun nanocomposite poly(vinylidene fluoride) mats with tunable wettability

Haddad

Svinterikos

Zuburtikudis

2017

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…49,50 Fibroblasts grown on piezoelectrically-activated (presenting charge on surface) implants show enhanced migration, adhesion and secretion and the implants themselves showed higher fibrosis levels in rats in vivo, illustrating wound healing capabilities. 51 However, in order to elucidate the fundamental basis for the observed improved cellular function due to charge, synthetic biology techniques can be employed. The ferroelectric properties of certain crystals such as Lithium Niobate have been exploited recently to investigate the role of charge on cell behavior, and show great promise.…”

Section: Effect Of Substrate Stiffnessmentioning

confidence: 99%

Elucidating the molecular mechanisms underlying cellular response to biophysical cues using synthetic biology approaches

Denning

Roos

2016

Cell Adhesion & Migration

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The use of synthetic surfaces and materials to influence and study cell behavior has vastly progressed our understanding of the underlying molecular mechanisms involved in cellular response to physicochemical and biophysical cues. Reconstituting cytoskeletal proteins and interfacing them with a defined microenvironment has also garnered deep insight into the engineering mechanisms existing within the cell. This review presents recent experimental findings on the influence of several parameters of the extracellular environment on cell behavior and fate, such as substrate topography, stiffness, chemistry and charge. In addition, the use of synthetic environments to measure physical properties of the reconstituted cytoskeleton and their interaction with intracellular proteins such as molecular motors is discussed, which is relevant for understanding cell migration, division and structural integrity, as well as intracellular transport. Insight is provided regarding the next steps to be taken in this interdisciplinary field, in order to achieve the global aim of artificially directing cellular response.

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Piezoelectric PU/PVDF electrospun scaffolds for wound healing applications

Cited by 221 publications

References 33 publications

Strategies for the development of three dimensional scaffolds from piezoelectric poly(vinylidene fluoride)

Strategies for the development of three dimensional scaffolds from piezoelectric poly(vinylidene fluoride)

Designing electrospun nanocomposite poly(vinylidene fluoride) mats with tunable wettability

Elucidating the molecular mechanisms underlying cellular response to biophysical cues using synthetic biology approaches

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