Piezoelectric point-of-care biosensor for the detection of SARS-COV-2 (COVID-19) antibodies

Mandal, Debdyuti; Indaleeb, Mustahseen M.; Younan, Alexandra; Banerjee, Subhasis

doi:10.1016/j.sbsr.2022.100510

Cited by 16 publications

(17 citation statements)

References 25 publications

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“…[ 119 ] For example, the sonopiezoelectric LiNbO 3 wafer functionalized with the SARS‐COV‐2 antigen as a diagnostic sensor was developed to detect the latent antibodies of SARS‐COV‐2. [ 120 ] The reliable diagnostic precision of this sensor at very small sample concentrations in different biological samples confirmed the detection feasibility, which is prominent for the vaccine exploitation.…”

Section: Sonopiezoelectric Biosensingmentioning

confidence: 62%

Sonopiezoelectric Nanomedicine and Materdicine

Wang

Dai

Chen

2023

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Endogenous electric field is ubiquitous in a multitude of important living activities such as bone repair, cell signal transduction, and nerve regeneration, signifying that regulating the electric field in organisms is highly beneficial to maintain organism health. As an emerging and promising research direction, piezoelectric nanomedicine and materdicine precisely activated by ultrasound with synergetic advantages of deep tissue penetration, remote spatiotemporal selectivity, and mechanical‐electrical energy interconversion, have been progressively utilized for disease treatment and tissue repair by participating in the modulation of endogenous electric field. This specific nanomedicine utilizing piezoelectric effect activated by ultrasound is typically regarded as “sonopiezoelectric nanomedicine”. This comprehensive review summarizes and discusses the substantially employed sonopiezoelectric nanomaterials and nanotherapies to provide an insight into the internal mechanism of the corresponding biological behavior/effect of sonopiezoelectric biomaterials in versatile disease treatments. This review primarily focuses on the sonopiezoelectric biomaterials for biosensing, drug delivery, tumor therapy, tissue regeneration, antimicrobia, and further illuminates the underlying sonopiezoelectric mechanism. In addition, the challenges and developments/prospects of sonopiezoelectric nanomedicine are analyzed for promoting the further clinical translation. It is earnestly expected that this kind of nanomedicine/biomaterials‐enabled sonopiezoelectric technology will provoke the comprehensive investigation and promote the clinical development of the next‐generation multifunctional materdicine.

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Section: Sonopiezoelectric Biosensingmentioning

confidence: 62%

Sonopiezoelectric Nanomedicine and Materdicine

Wang

Dai

Chen

2023

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“…[35,36] Piezoelectric biosensors were reported for the detection of S-IgM, [37,38] and S-IgG antibodies. [38,39] Luminescence was also used for the development of detection systems for spike protein [40][41][42] and antibody quantification. [42,43] High sensitivity performance has been obtained by these approaches, but elaborate fabrication techniques and instrumentation are usually required.…”

Section: The Rapid Transmission and Resilience Of Coronavirus Disease...mentioning

confidence: 99%

Duplex Electrochemical Microfluidic Sensor for COVID‐19 Antibody Detection: Natural versus Vaccine‐Induced Humoral Response

Mazzaracchio

Maciel

Santos

et al. 2023

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The rapid transmission and resilience of coronavirus disease 2019 (COVID‐19) have led to urgent demands in monitoring humoral response for effective vaccine development, thus a multiplex co‐detection platform to discriminate infection‐induced from vaccine‐induced antibodies is needed. Here a duplex electrochemical immunosensor for co‐detection of anti‐nucleocapsid IgG (N‐IgG) and anti‐spike IgG (S‐IgG) is developed by using a two‐working electrode system, via an indirect immunoassay, with antibody quantification obtained by differential pulse voltammetry. The screen‐printed electrodes (SPEs) are modified by carbon black and electrodeposited gold nanoflowers for maximized surface areas, enabling the construction of an immunological chain for S‐IgG and N‐IgG electrochemical detection with enhanced performance. Using an optimized immunoassay protocol, a wide linear range between 30–750 and 20–1000 ng mL−1, and a limit of detection of 28 and 15 ng mL−1 are achieved to detect N‐IgG and S‐IgG simultaneously in serum samples. This duplex immunosensor is then integrated in a microfluidic device to obtain significantly reduced detection time (≤ 7 min) while maintaining its analytical performance. The duplex microfluidic immunosensor can be easily expanded into multiplex format to achieve high throughput screening for the sero‐surveillance of COVID‐19 and other infectious diseases.

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“…The principle of antibody assays by a piezoelectric biosensor can be learned from Figure 3 . An ultrasonic guided wave sensor using lithium niobate piezoelectric wafer was prepared and verified by Mandal and coworkers [ 98 ]. The piezoelectric biosensor contained the S protein immobilized through gold nanoparticles and exerted the signal when a sample containing total anti-SARS-CoV-2 antibodies presented.…”

Section: Biosensors For Measuring Anti-covid-19 Antibodiesmentioning

confidence: 99%

Progress in Biosensors for the Point-of-Care Diagnosis of COVID-19

Pohanka

2022

Sensors

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Coronavirus disease 2019 (COVID-19) is a highly virulent infection that has caused a pandemic since 2019. Early diagnosis of the disease has been recognized as one of the important approaches to minimize the pathological impact and spread of infection. Point-of-care tests proved to be substantial analytical tools, and especially lateral flow immunoassays (lateral flow tests) serve the purpose. In the last few years, biosensors have gained popularity. These are simple but highly sensitive and accurate analytical devices composed from a selective molecule such as an antibody or antigen and a sensor platform. Biosensors would be an advanced alternative to current point-of-care tests for COVID-19 diagnosis and standard laboratory methods as well. Recent discoveries related to point-of-care diagnostic tests for COVID-19, the development of biosensors for specific antibodies and specific virus parts or their genetic information are reviewed.

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Piezoelectric point-of-care biosensor for the detection of SARS-COV-2 (COVID-19) antibodies

Cited by 16 publications

References 25 publications

Sonopiezoelectric Nanomedicine and Materdicine

Sonopiezoelectric Nanomedicine and Materdicine

Duplex Electrochemical Microfluidic Sensor for COVID‐19 Antibody Detection: Natural versus Vaccine‐Induced Humoral Response

Progress in Biosensors for the Point-of-Care Diagnosis of COVID-19

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