375wileyonlinelibrary.com the human body and bulky devices [3][4][5] ; the unnatural appearance owing to the infl exibility of electronics [ 6 ] ; and the signal artifacts that originate from the non-conformal attachment of the rigid sensors to the human body. [3][4][5] Therefore, novel ultrathin devices that can be conformally laminated onto human skin such that they have natural appearance, comfort, and high signal-to-noise ratio (SNR) are desired.The adoption of fl exible and stretchable designs and a concomitant reduction in the thickness and weight of devices are key goals with respect to the design of wearable electronics. Signifi cant efforts have been made recently, including the development of stretchable inorganic electronics, [ 3,4,7 ] ultrathin and lightweight organic sensors, [ 8,9 ] fl exible nanomaterialbased electronic skins, [ 10,11 ] self-powered motion sensors based on the triboelectric effect, [ 12,13 ] and highly sensitive fl exible mechanical sensors. [14][15][16][17] Ultrathin and deformable designs allow for accurate data acquisition from the human body with minimum signal artifacts. However, these previously reported devices are made of opaque semiconductors and metals, which look different from human skin. In addition, many of these sensors lack power supply devices [3][4][5] and thus self-powering is important.Transparent electronic nanomaterials can make wearable devices invisible, resulting in a natural look and improved aesthetics. For example, carbon-based nanomaterials (such as graphene (GP) [ 18 ] and carbon nanotubes [ 19 ] and metal nanowire (NW) networks (such as silver NWs [ 20 ] and gold NWs [ 21 ] have been intensively researched. These transparent nanomaterials An interactive human-machine interface (iHMI) enables humans to control hardware and collect feedback information. In particular, wearable iHMI systems have attracted tremendous attention owing to their potential for use in personal mobile electronics and the Internet of Things. Although significant progress has been made in the development of iHMI systems, those based on rigid electronics have constraints in terms of wearability, comfortability, signal-to-noise ratio (SNR), and aesthetics. Herein the fabrication of a transparent and stretchable iHMI system composed of wearable mechanical sensors and stimulators is reported. The ultrathin and lightweight design of the system allows superior wearability and high SNR. The use of conductive/piezoelectric graphene heterostructures, which consist of poly( L -lactic acid), single-walled carbon nanotubes, and silver nanowires, results in high transparency, excellent performance, and low power consumption as well as mechanical deformability. The control of a robot arm for various motions and the feedback stimulation upon successful executions of commands are demonstrated using the wearable iHMI system.