Piezoelectric materials for ultrasound-driven dissociation of Alzheimer's β-amyloid aggregate structure

Jang, Jinhyeong; Kim, Kayoung; Yoon, Jaeho; Park, Chan Beum

doi:10.1016/j.biomaterials.2020.120165

Cited by 52 publications

(88 citation statements)

References 78 publications

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“…Moreover, certain substances, referred to as piezoelectric materials, facilitate the transference of charge carriers to reactants when they receive mechanical stimuli [ 122 ], resulting in the induction of electrochemical reactions [ 123 ]. A study evaluated the activity of piezoelectric bismuth oxychloride (BiOCl) nanosheets in promoting the breakdown of Aβ aggregates via ultrasound-induced redox reactions [ 123 ]. Thus, these BiOCl nanosheets are biologically compatible materials which exhibit piezoelectric actions in response to ultrasound [ 123 ].…”

Section: Therapeutic Agents Targeting Amyloid Cascade Eventsmentioning

confidence: 99%

“…A study evaluated the activity of piezoelectric bismuth oxychloride (BiOCl) nanosheets in promoting the breakdown of Aβ aggregates via ultrasound-induced redox reactions [ 123 ]. Thus, these BiOCl nanosheets are biologically compatible materials which exhibit piezoelectric actions in response to ultrasound [ 123 ]. It is well known that sonic-activated BiOCl nanosheets induce oxidative stress, promoting the destabilization of β-sheets.…”

Section: Therapeutic Agents Targeting Amyloid Cascade Eventsmentioning

confidence: 99%

Section: Therapeutic Agents Targeting Amyloid Cascade Eventsmentioning

confidence: 99%

“…It is well known that sonic-activated BiOCl nanosheets induce oxidative stress, promoting the destabilization of β-sheets. Additionally, these nanosheets have been observed to minimize the neurotoxic potential of Aβ aggregates (Figure 3) [123]. degrading enzyme in the blood serum was elevated as a result of treatment with statins, while it was retarded in the cell pellets, which showed the selective stimulation of the secretion of insulindegrading enzyme in the peripheral cells [55].…”

Section: Other Agents Targeting Aβ Depositsmentioning

confidence: 99%

“…However, NSAIDs are still considered to be potential therapeutic agents, as they are capable of modulating the effects of γ-secretase enzyme [55]. Moreover, certain substances, referred to as piezoelectric materials, facilitate the transference of charge carriers to reactants when they receive mechanical stimuli [123], resulting in the induction of electrochemical reactions [124]. A study evaluated the activity of piezoelectric bismuth oxychloride (BiOCl) nanosheets in promoting the breakdown of Aβ aggregates via ultrasound-induced redox reactions [124].…”

Section: Other Agents Targeting Aβ Depositsmentioning

confidence: 99%

See 4 more Smart Citations

Exploring the Potential of Therapeutic Agents Targeted towards Mitigating the Events Associated with Amyloid-β Cascade in Alzheimer’s Disease

Behl

Kaur

Frățilă

et al. 2020

IJMS

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One of the most commonly occurring neurodegenerative disorders, Alzheimer’s disease (AD), encompasses the loss of cognitive and memory potential, impaired learning, dementia and behavioral defects, and has been prevalent since the 1900s. The accelerating occurrence of AD is expected to reach 65.7 million by 2030. The disease results in neural atrophy and disrupted inter-neuronal connections. Amongst multiple AD pathogenesis hypotheses, the amyloid beta (Aβ) cascade is the most relevant and accepted form of the hypothesis, which suggests that Aβ monomers are formed as a result of the cleavage of amyloid precursor protein (APP), followed by the conversion of these monomers to toxic oligomers, which in turn develop β-sheets, fibrils and plaques. The review targets the events in the amyloid hypothesis and elaborates suitable therapeutic agents that function by hindering the steps of plaque formation and lowering Aβ levels in the brain. The authors discuss treatment possibilities, including the inhibition of β- and γ-secretase-mediated enzymatic cleavage of APP, the immune response generating active immunotherapy and passive immunotherapeutic approaches targeting monoclonal antibodies towards Aβ aggregates, the removal of amyloid aggregates by the activation of enzymatic pathways or the regulation of Aβ circulation, glucagon-like peptide-1 (GLP-1)-mediated curbed accumulation and the neurotoxic potential of Aβ aggregates, bapineuzumab-mediated vascular permeability alterations, statin-mediated Aβ peptide degradation, the potential role of ibuprofen and the significance of natural drugs and dyes in hindering the amyloid cascade events. Thus, the authors aim to highlight the treatment perspective, targeting the amyloid hypothesis, while simultaneously emphasizing the need to conduct further investigations, in order to provide an opportunity to neurologists to develop novel and reliable treatment therapies for the retardation of AD progression.

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Section: Therapeutic Agents Targeting Amyloid Cascade Eventsmentioning

confidence: 99%

Section: Therapeutic Agents Targeting Amyloid Cascade Eventsmentioning

confidence: 99%

Section: Therapeutic Agents Targeting Amyloid Cascade Eventsmentioning

confidence: 99%

Section: Other Agents Targeting Aβ Depositsmentioning

confidence: 99%

Section: Other Agents Targeting Aβ Depositsmentioning

confidence: 99%

See 3 more Smart Citations

Exploring the Potential of Therapeutic Agents Targeted towards Mitigating the Events Associated with Amyloid-β Cascade in Alzheimer’s Disease

Behl

Kaur

Frățilă

et al. 2020

IJMS

View full text Add to dashboard Cite

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Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies

Xin,

Liu,

Xiao

et al. 2024

Adv Funct Materials

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Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional antibiotic therapies futile, prompting the development of new antimicrobial technologies. Photoactive nanomaterials have thus garnered a thriving interest for disinfection owing to their superior antibacterial efficaciousness, favorable biosafety, and rapidness and spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances and emerging trends in the design, nanoengineering, and bioapplications of photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, and antibacterial mechanisms of nanomaterials and phototherapy. Subsequently, the regulation of the antibacterial effectiveness of photoactive nanomaterials is comprehensively discussed, centering on criteria and strategies for tuning photoabsorption spectra, photothermal conversion, and photocatalytic efficiency, alongside tactics for enabling synergistic therapies. This is followed by comparative analyses of techniques and modalities for synthesizing and engineering photoactive nanomaterials with diverse structures, forms, and functionalities. Thereafter, the state‐of‐the‐art applications of phototherapies across various medical sectors are portrayed, and key challenges and opportunities are finally discussed to spur future innovations and translation. This review is envisaged to provide useful guidance for devising and developing nanomaterials‐based photoresponsive antimicrobials with application‐specific materials properties and biological functions.

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Strategies to Reverse Hypoxic Tumor Microenvironment for Enhanced Sonodynamic Therapy

Li,

Yue,

Tang

et al. 2023

Adv Healthcare Materials

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Sonodynamic therapy (SDT) has emerged as a highly effective modality for the treatment of malignant tumors owing to its powerful penetration ability, noninvasiveness, site‐confined irradiation and excellent therapeutic efficacy. However, the traditional SDT, which relies on oxygen availability, often fails to generate a satisfactory level of reactive oxygen species (ROS) because of the widespread issue of hypoxia in the tumor microenvironment (TME) of solid tumors. To address this challenge, various approaches have been developed to alleviate hypoxia and improve the efficiency of SDT. These strategies aim to either increase oxygen supply or prevent hypoxia exacerbation, thereby enhancing the effectiveness of SDT. In view of this, the current review provides an overview of these strategies and their underlying principles, focusing on the circulation of oxygen from consumption to external supply. The detailed research examples conducted using these strategies in combination with SDT were also discussed. Additionally, this review highlights the future prospects and challenges of the hypoxia‐alleviated SDT, along with the key considerations for future clinical applications. These considerations include the development of efficient oxygen delivery systems, the accurate methods for hypoxia detection, and the exploration of combination therapies to optimize SDT outcomes.This article is protected by copyright. All rights reserved

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Piezoelectric materials for ultrasound-driven dissociation of Alzheimer's β-amyloid aggregate structure

Cited by 52 publications

References 78 publications

Exploring the Potential of Therapeutic Agents Targeted towards Mitigating the Events Associated with Amyloid-β Cascade in Alzheimer’s Disease

Exploring the Potential of Therapeutic Agents Targeted towards Mitigating the Events Associated with Amyloid-β Cascade in Alzheimer’s Disease

Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies

Strategies to Reverse Hypoxic Tumor Microenvironment for Enhanced Sonodynamic Therapy

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