Piezoelectric Immunosensors for Toxins' Detection in Foodstuffs

Karaseva, Nadezhda; Ermolaeva, T. N.

doi:10.4028/www.scientific.net/kem.543.515

Cited by 2 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The same authors later demonstrated applicability to contaminated milk samples . Others have used a similar piezoelectric immunosensor based on monoclonal antibodies to detect SEA in chicken meat and milk with improvements to sensitivity (0.4 ng/mL) …”

Section: Physical Techniquesmentioning

confidence: 99%

“…1011 Others have used a similar piezoelectric immunosensor based on monoclonal antibodies to detect SEA in chicken meat and milk with improvements to sensitivity (0.4 ng/mL). 1012 Cantilever devices are also capable of multiplexed and sensitive detection with minimal sample waste and usage time. Microcantilever sensors can similarly respond to surface stress changes produced by a biorecognition event.…”

Section: ■ Spectroscopic Sensorsmentioning

confidence: 99%

See 1 more Smart Citation

Detecting Biothreat Agents: From Current Diagnostics to Developing Sensor Technologies

et al. 2018

View full text Add to dashboard Cite

Although a fundamental understanding of the pathogenicity of most biothreat agents has been elucidated and available treatments have increased substantially over the past decades, they still represent a significant public health threat in this age of (bio)terrorism, indiscriminate warfare, pollution, climate change, unchecked population growth, and globalization. The key step to almost all prevention, protection, prophylaxis, post-exposure treatment, and mitigation of any bioagent is early detection. Here, we review available methods for detecting bioagents including pathogenic bacteria and viruses along with their toxins. An introduction placing this subject in the historical context of previous naturally occurring outbreaks and efforts to weaponize selected agents is first provided along with definitions and relevant considerations. An overview of the detection technologies that find use in this endeavor along with how they provide data or transduce signal within a sensing configuration follows. Current "gold" standards for biothreat detection/diagnostics along with a listing of relevant FDA approved in vitro diagnostic devices is then discussed to provide an overview of the current state of the art. Given the 2014 outbreak of Ebola virus in Western Africa and the recent 2016 spread of Zika virus in the Americas, discussion of what constitutes a public health emergency and how new in vitro diagnostic devices are authorized for emergency use in the U.S. are also included. The majority of the Review is then subdivided around the sensing of bacterial, viral, and toxin biothreats with each including an overview of the major agents in that class, a detailed cross-section of different sensing methods in development based on assay format or analytical technique, and some discussion of related microfluidic lab-on-a-chip/point-of-care devices. Finally, an outlook is given on how this field will develop from the perspective of the biosensing technology itself and the new emerging threats they may face.

show abstract

Section: Physical Techniquesmentioning

confidence: 99%

Section: ■ Spectroscopic Sensorsmentioning

confidence: 99%