Piezoelectric ceramic implants: A feasibility study

Park, J. B.; Recum, Andreas F. von; Kenner, G.H.; Kelly, Brian; Coffeen, William W.; Grether, M. F.

doi:10.1002/jbm.820140308

Cited by 48 publications

(26 citation statements)

References 10 publications

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“…To this purpose, in vivo conditions are highly suitable, as a natural load is continuously applied to the implanted material, thus exerting its piezoelectric characteristics. Several experiments were carried out, implanting piezoelectric BaTiO 3 , polyvinylidene fluoride (PVDF), HABT, and [P(VDF-TrFE)-BaTiO 3 ] inside canine femora, as well as inside rat and rabbit tibiae [59][60][61][62]. Results clearly showed that the piezoelectric nature of the poled and mechanically loaded materials contributed to the improvement of biological responses.…”

Section: Bone Tissue Engineeringmentioning

confidence: 95%

Applications of Piezoelectricity in Nanomedicine

Ciofani

Danti

Ricotti

et al. 2012

Nanomedicine and Nanotoxicology

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Abstract. In this Chapter, recent results about studies of interactions between piezoelectric nanoparticles and living systems will be discussed. As extremely innovative materials, great importance is devoted to the investigations of their stabilisation in physiological environments and to their biocompatibility. Applications as drug carriers and nanovectors will be thereafter described, and special attention will be dedicated to tissue engineering applications. Finally, preliminary results achieved by our group on "wireless" cell stimulation will be approached. IntroductionNanotechnology refers to the research and technology development at atomic, molecular and macromolecular scales, which leads to the controlled manipulation and study of structures and devices with length scales in the range of 1-100 nm [1].In the latest two decades, the research on nanotechnology has grown explosively with over 300,000 publications in the field of nanosciences according to ISI Web of Science. Among these spectacular developments, a new emerging field that combines nanotechnology and biotechnology -nanobiotechnology -is receiving a growing attention [2]. Nanostructured materials own unique properties which are of great interest for their potential applications as biomaterials, such as the large "surface-area to volume" ratio. Since life itself, fundamentally, is a collection of nanoscale processes occurring within cells [3], it is unavoidable and necessary to understand the impacts of the presence of nanomaterials inside the cells when one explores advantages and promises of nanomaterials for biomedical applications.In fact, it has been demonstrated that nanomaterials can interact both positively and negatively with different biological systems. Carbon nanotubes (CNTs), for

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Section: Bone Tissue Engineeringmentioning

confidence: 95%

Applications of Piezoelectricity in Nanomedicine

Ciofani

Danti

Ricotti

et al. 2012

Nanomedicine and Nanotoxicology

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“…In agreement with earlier work, increased ossification was found on piezoelectric films made from PLLA in a rabbit model. 50 A further study showing an improved biological response to piezoelectric materials was carried out by Feng et al 12 As with the earlier studies, 44,45 BaTiO 3 -containing ceramics were implanted in canine subjects. In this case, the piezoelectric material was in the form of a hydroxyapatite-barium titanate (HABT) composite.…”

Section: In Vivo Studiesmentioning

confidence: 97%

“…45 Ceramic samples with porous surfaces and a voltage coefficient (g 33 ) of approximately 9 9 10 À3 mVN À1 were implanted into canine femora (specifically, into the cortex of the femoral midshaft). The g 33 coefficient is a measure of electric field generated per unit stress.…”

Section: In Vivo Studiesmentioning

confidence: 99%

Electrically Active Bioceramics: A Review of Interfacial Responses

et al. 2010

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Electrical potentials in mechanically loaded bone have been implicated as signals in the bone remodeling cycle. Recently, interest has grown in exploiting this phenomenon to develop electrically active ceramics for implantation in hard tissue which may induce improved biological responses. Both polarized hydroxyapatite (HA), whose surface charge is not dependent on loading, and piezoelectric ceramics, which produce electrical potentials under stress, have been studied in order to determine the possible benefits of using electrically active bioceramics as implant materials. The polarization of HA has a positive influence on interfacial responses to the ceramic. In vivo studies of polarized HA have shown polarized samples to induce improvements in bone ingrowth. The majority of piezoelectric ceramics proposed for implant use contain barium titanate (BaTiO(3)). In vivo and in vitro investigations have indicated that such ceramics are biocompatible and, under appropriate mechanical loading, induce improved bone formation around implants. The mechanism by which electrical activity influences biological responses is yet to be clearly defined, but is likely to result from preferential adsorption of proteins and ions onto the polarized surface. Further investigation is warranted into the use of electrically active ceramics as the indications are that they have benefits over existing implant materials.

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“…Their first application to the biomaterials area was with the discovery of lead-free piezoelectric ceramic barium titanate (BaTiO 3 ) (Park et al, 1980). Lithium sodium potassium niobate has broadened the scope of lead-free piezoelectric ceramics owing to its better and more stable piezoelectricity than barium titanate (Saito et al, 2004).…”

Section: Discussionmentioning

confidence: 99%