Piezoelectric and related properties of hydrated collagen

Fukada, E.; Ueda, Hiroyoshi; Rinaldi, Rossella

doi:10.1016/s0006-3495(76)85741-4

Cited by 50 publications

(36 citation statements)

References 20 publications

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“…It seems evident from the literature that the piezoelectric effect can be attributed to the main organic constituent of tissue, which is collagen in the case of the bone and tendons [82][83]. Thus, it has been shown that the crystalline unit of collagen is polar hexagonal (C 6 ) [56], showing piezoelectric properties.…”

Section: Collagen and Others Piezoelectric Tissuesmentioning

confidence: 99%

Piezoelectric polymers as biomaterials for tissue engineering applications

Ribeiro

Sencadas

Correia

et al. 2015

Colloids and Surfaces B: Biointerfaces

407

338

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Tissue engineering often rely on scaffolds for supporting cell differentiation and growth. Novel paradigms for tissue engineering include the need of active or smart scaffolds in order to properly regenerate specific tissues. In particular, as electrical and electromechanical clues are among the most relevant ones in determining tissue functionality in tissues such as muscle and bone, among others, electroactive materials and, in particular, piezoelectric ones, show strong potential for novel tissue engineering strategies, in particular taking also into account the existence of these phenomena within some specific tissues, indicating their requirement also during tissue regeneration. This referee reports on piezoelectric materials used for tissue engineering applications. The most used materials for tissue engineering strategies are reported together with the main achievements, challenges and future needs for research and actual therapies. This review provides thus a compilation of the most relevant results and strategies and a start point for novel research pathways in the most relevant and challenging open questions. This referee reports on piezoelectric materials used for tissue engineering applications.The most used materials for tissue engineering strategies are reported together with the main achievements, challenges and future needs for research and actual therapies. This referee provides thus a compilation of the most relevant results and strategies and a start point for novel research pathways in the most relevant and challenging open questions.

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Section: Collagen and Others Piezoelectric Tissuesmentioning

confidence: 99%

Piezoelectric polymers as biomaterials for tissue engineering applications

Ribeiro

Sencadas

Correia

et al. 2015

Colloids and Surfaces B: Biointerfaces

407

338

View full text Add to dashboard Cite

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“…2,1979 origins of these relaxations have not been well understood. In a previous paper 9 we proposed tentative interpretations for the piezoelectric relaxations in collagen shown in Figure 1, where maxima of e" were seen at -100, -50, and -30°C. The relaxation around -100°C is associated with the local mode relaxation of main chains of collagen, that around -50°C with the side chain relaxation, and that around -30°C with the increase in ionic conductivity.…”

Section: Discussionmentioning

confidence: 82%

“…The dielectric constant, <:=s' -is", was measured at 10, 20, and 64 Hz in a temperature range from -150 to + 150°C. 9 Measurements of the static piezoelectricity were also carried out. A static stress of about 1.5 kg/cm 2 was applied to the sample by passing a constant d.c. current through a moving coil of the driver.…”

Section: Methodsmentioning

confidence: 99%

“…c:/ (aa1 +a2) (9) and ac/ +c/ r= 4n:(aal +a2) (10) where r-1 =e1'/4na1 is the dielectric relaxation time for layer 1, and r 2=c://4na2 is the dielectric relaxation time for layer 2, and r is the MaxwellWagner relaxation time for the two layers. Observation of the temperature dependence of c1 (gelatin) and c:2 (collagen) for samples equilibrated at 84-% RH shows that c:da1 is about one order larger than c:2'/a" below about -10°C.…”

Section: )mentioning

confidence: 99%

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Piezoelectric Relaxations in Collagen Gelatin Systems

Ueda

Fukada

1979

Polym J

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ABSTRACT:Films consisting of three joined layers of gelatin, oriented collagen, and gelatin were prepared. The temperature dependence of piezoelectric constants (d=d' -id" and e=e ' -ie") was determined at 10Hz for the combined films with different hydrations.At a moisture content above 30 wt %, d' and e' decreased with increasing temperature just above -100°C, and their signs reversed around -30°C, and approached zero around room temperature. The temperature dependence of the piezoelectric current induced by static stress was also determined for a film with a moisture content of about 33 wt %. The sign reversal of the decaying current was observed at intermediate temperatures in accord with the sign reversal of d' in a.c. measurements. The theoretical explanation for this was given on the basis of the Maxwell-Wagner type dielectric relaxation in a two phase system and the decay of piezoelectric polarization in collagen layer. The same explanation may be applied for the temperature dependence of the piezoelectric constant of bone, which consists of collagen fibers and hydroxyapatite.KEY WORDSThe frequency and temperature dependence of the piezoelectric, elastic, and dielectric constants is influenced by the inhomogeneous structure in polymers. A mechanical relaxation due to the inhomogeneity in dispersed systems is caHed the Frohlich-Sack effect. 1 A dielectric relaxation due to the inhomogeneity is cailed the MaxweiiWagner effect. 2 The theoretical interpretation for the piezoelectric relaxations in polymers is often based upon a two phase model, consisting of the piezoelectric phase and the nonpiezoelectric phase. 3 ' 4 A three-phase model consisting of the piezoelectric phase, the nonpiezoelectric phase and the boundary phase has been also proposed. 5 Hydration in polymers influences their elastic and dielectric properties. In general d.c. conductivity in polymers increases with an increase in hydration. Some polymers change their structure due to hydration. 6 ' 7 For these reasons, the piezoelectric properties of polymer are also influenced by hydration. 8 ' 9 In order to investigate in detail the influence of hydration on the piezoelectricity of polymers, a model experiment was undertaken using the combined films of coilagen and gelation of different hydrations. The combined film is a model system for the piezoelectric polymer; the coilagen layer being the piezoelectric phase and the gelation layer the nonpiezoelectric phase. EXPERIMENTALCombined films of coilagen and gelatin were prepared in the foiiowing way. CoHagen tapes, 2-mm wide and 0.09-mm thick, having been oriented longitudinaily during manufacture, were joined together breadthwise to increase their width using water as an adhesive. Such a coilagen film was placed on gelation gel prepared in a nylon ceil, and the gelatin solution was poured over the coHagen film. After drying in air for several days, a combined film consisting of paraiiel layers of gelatin, coHagen and gelatin was obtained. The thickness of the coHagen layer was approximately ...

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“…Se pueden construir modelos no lineales que justifiquen la transferencia de señales ondulatorias y establezcan marcos conceptuales entre el exceso de energía que se libera en la hidrólisis de GTP después del ensamble de la tubulina y las funciones que se le atribuyen a los MT (59). Sus propiedades piezoeléctricas sugieren interpretaciones entre la estructura interna de los axones y su función principal como es la comunicación sináptica.…”

Section: Transporte De Solitones En Los Mt: Un Modelo Clásicounclassified

Microtúbulos y terapia neural: propuesta de una investigación promisoria

Cruz

Fayad

2011

Rev. Med.

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<p>La terapia neural es una práctica médica no convencional en la cual se inyectan anestésicos locales (procaína o lidocaína) en concentraciones en un rango de 1 – 10 mg/ml, en cantidades entre 1-10 cm3, en diferentes partes del cuerpo con fines terapéuticos mas no anestésicos. El mecanismo de acción de los anestésicos locales en esta terapia no se conoce. La posible acción remota de la procaína, el efecto de sus propiedades eléctricas en el transporte de señales en el sistema nervioso y en el restablecimiento del potencial fisiológico de membrana son temas centrales de la terapia neural que requieren una interpretación físico-química. En este artículo proponemos que la propagación de señales en microtúbulos neuronales podría estar involucrada en los mecanismos de acción de la procaína en terapia neural. Sugerimos algunos estudios experimentales que conduzcan a una interpretación científica rigurosa de las observaciones reportadas y de los efectos remotos que se atribuyen a la inyección de procaína en terapia neural.</p>

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Piezoelectric and related properties of hydrated collagen

Cited by 50 publications

References 20 publications

Piezoelectric polymers as biomaterials for tissue engineering applications

Piezoelectric polymers as biomaterials for tissue engineering applications

Piezoelectric Relaxations in Collagen Gelatin Systems

Microtúbulos y terapia neural: propuesta de una investigación promisoria

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