Piezoelectric Activatable Nanozyme-Based Skin Patch for Rapid Wound Disinfection

Abstract

Nanozymes are promising new-generation antibacterial agents owing to their low cost, high stability, broadspectrum activity, and minimal antimicrobial resistance. However, the inherent low catalytic activity of nanozymes tends to limit their antibacterial efficacy. Herein, a heterostructure of zinc oxide nanorod@graphdiyne nanosheets (ZnO@GDY NR) with unparallel piezocatalytic enzyme mimic activity is reported, which concurrently possesses intrinsic peroxidase-like activity and strong piezoelectric responses and effectively promotes the decomposition of hydrogen peroxide (H 2 O 2 ) and generation of reactive oxygen species under ultrasound irradiation. Moreover, this piezocatalytic nanozyme exhibits almost 100% antibacterial efficacy against multidrug-resistant pathogens involving methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa in vitro and in vivo. In addition, a piezoelectric activatable nanozyme-based skin patch is developed for rapid skin wound disinfections with satisfactory hemocompatibility and cytocompatibility. This work not only sheds light on the development of an innovative piezoelectric activatable nanozyme-based skin patch for rapid wound disinfection but also provides new insights on the engineering of piezocatalytic nanozymes for nanozyme antibacterial therapy.

Recent Progress on Hydrogel-Based Piezoelectric Devices for Biomedical Applications

“…The use of the enzyme hydrogen peroxide catalase, which promotes the decomposition of hydrogen peroxide to produce oxygen, not only prevents anaerobic bacteria from proliferating in the wound, but also accelerates the healing of the wound tissue. It is worth noting that this novel skin patch was able to heal a 7 mm diameter wound on the back of a mouse in 9 days [ 94 ]. Liang et al also innovated in the preparation technique by producing the first PVDF/sodium alginate (SA) scaffold with 0.5% ZnO nanoparticles using a 3D printing method.…”

Piezoelectric Nanoparticles for Ultrasound-Based Wireless Therapies

“…The size and shape of the nanoparticles are controlled by controlling the nucleation-growth kinetics via changing the experimental conditions. 39 Important, recent, and interesting examples of such nanoparticles are ultrasmall BaTiO 3 nanoparticle, 40 ZnO nanorod, 41 NaNbO 3 nanorod, 22 BaTiO 3 nanorod, 20 ZnSnO 3 nanoparticle, 7 and hydroxyapatite nanowire. 24 Figure 2 shows representative examples of commonly known piezoelectric nanoparticles.…”

“…A heterostructure of zinc oxide nanorod−graphdiyne nanosheets shows a strong piezoelectric response, promotes decomposition of H 2 O 2 , and produces ROS under ultrasound. 41 This piezoelectric nanohybrid shows 100% antibacterial efficiency against multidrug-resistant pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa. In addition, the nanohybrid-based skin patch has been developed for rapid wound healing.…”

Transparent glass-nanocomposites possessing piezoelectric ZnO/Zn2SiO4 nanocrystallites for piezocatalytic dye degradation

“…To explore piezocatalytic dye degradation capability of glass nanocomposites, the present study was planned. ZnO 29 and β -Zn 2 SiO 4 30 are known piezoelectric materials. Thus, these potential piezoelectric crystals can be crystallized in glass matrix to induce piezocatalytic dye degradation.…”