Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells

Mochida, Yuki; Ochiai, Koji; Nagase, Takeshi; Nonomura, Kazuteru; Akimoto, Yoshihiro; Fukuhara, Hiroshi; Sakai, Tatsuo; Matsumura, George; Yamaguchi, Yoshihiro; Nagase, Miki

doi:10.1038/s41598-022-07987-7

Cited by 17 publications

(17 citation statements)

References 54 publications

(81 reference statements)

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“…PIEZO2 encodes a sensor for mechanical forces in mesangial cells and renin-producing cells [53]. During dehydration, PIEZO2 expression is down-regulated in mesangial cells and up-regulated in juxtaglomerular renin-producing cells, and there is overproduction of renin and renin-producing cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…During dehydration, PIEZO2 expression is down-regulated in mesangial cells and up-regulated in juxtaglomerular renin-producing cells, and there is overproduction of renin and renin-producing cell proliferation. The expression of renin is also reduced by PIEZO2 knockdown in juxtaglomerular cells, which demonstrates that PIEZO2 is an important regulator of glomerular filtration and body fluid status [53]. PIEZO2 is also a mechanical sensor for bladder tension [54, 55].…”

Section: Discussionmentioning

confidence: 99%

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Genome-Wide Association Studies for Albuminuria of Nondiabetic Taiwanese Population

Yang,

Chuang,

Che

et al. 2023

Am J Nephrol

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Introduction: Chronic kidney disease, which is defined by a reduced estimated glomerular filtration rate and albuminuria, imposes a large health burden worldwide. Ethnicity-specific associations are frequently observed in genome-wide association studies (GWAS). This study conducts a GWAS of albuminuria in the nondiabetic population of Taiwan. Methods: Nondiabetic individuals aged 30–70 years without a history of cancer were enrolled from the Taiwan Biobank. A total of 6,768 subjects were subjected to a spot urine examination. After quality control using PLINK and imputation using SHAPEIT and IMPUTE2, a total of 3,638,350 single-nucleotide polymorphisms (SNPs) remained for testing. SNPs with a minor allele frequency of less than 0.1% were excluded. Linear regression was used to determine the relationship between SNPs and log urine albumin-to-creatinine ratio. Results: Six suggestive loci are identified in or near the FCRL3 (p = 2.56 × 10−6), TMEM161 (p = 4.43 × 10−6), EFCAB1 (p = 2.03 × 10−6), ELMOD1 (p = 2.97 × 10−6), RYR3 (p = 1.34 × 10−6), and PIEZO2 (p = 2.19 × 10−7). Genetic variants in the FCRL3 gene that encode a secretory IgA receptor are found to be associated with IgA nephropathy, which can manifest as proteinuria. The PIEZO2 gene encodes a sensor for mechanical forces in mesangial cells and renin-producing cells. Five SNPs with a p-value between 5 × 10−6 and 5 × 10−5 are also identified in five genes that may have a biological role in the development of albuminuria. Conclusion: Five new loci and one known suggestive locus for albuminuria are identified in the nondiabetic Taiwanese population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Studies for Albuminuria of Nondiabetic Taiwanese Population

Yang,

Chuang,

Che

et al. 2023

Am J Nephrol

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“…At variance, Mochida et al 117 found that PIEZO2 was expressed in glomerular mesangial cells and renin-producing juxtaglomerular cells at both the mRNA and protein levels. Prior single-cell RNA sequencing of mouse glomerular cells showed that PIEZO2 was expressed at low levels in juxtaglomerular cells.…”

Section: Role Of Piezos In the Kidneymentioning

confidence: 97%

PIEZO Ion Channels in Cardiovascular Functions and Diseases

Coste,

Delmas

2024

Circulation Research

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The cardiovascular system provides blood supply throughout the body and as such is perpetually applying mechanical forces to cells and tissues. Thus, this system is primed with mechanosensory structures that respond and adapt to changes in mechanical stimuli. Since their discovery in 2010, PIEZO ion channels have dominated the field of mechanobiology. These have been proposed as the long-sought-after mechanosensitive excitatory channels involved in touch and proprioception in mammals. However, more and more pieces of evidence point to the importance of PIEZO channels in cardiovascular activities and disease development. PIEZO channel-related cardiac functions include transducing hemodynamic forces in endothelial and vascular cells, red blood cell homeostasis, platelet aggregation, and arterial blood pressure regulation, among others. PIEZO channels contribute to pathological conditions including cardiac hypertrophy and pulmonary hypertension and congenital syndromes such as generalized lymphatic dysplasia and xerocytosis. In this review, we highlight recent advances in understanding the role of PIEZO channels in cardiovascular functions and diseases. Achievements in this quickly expanding field should open a new road for efficient control of PIEZO-related diseases in cardiovascular functions.

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“…80 Additionally, it has been reported that glomerular mesangial cells and renin-producing cells express Piezo2, which was upregulated with renin overproduction in renin-producing cells in response to dehydration as a mechanical load reduction. 81 Whether in vivo loss of function of either Piezo1 or 2 affects renin expression remains to be determined. Other mechanosensitive ion channels, such as the Trpv4 (transient receptor potential vanilloid 4), have been reported to induce pressure-induced calcium transport and inhibit renin secretion.…”

Section: Nuclear Mechanotransduction and The Renin Cell Baroreceptormentioning

confidence: 99%

Renin Cells, From Vascular Development to Blood Pressure Sensing

2023

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During embryonic and neonatal life, renin cells contribute to the assembly and branching of the intrarenal arterial tree. During kidney arteriolar development renin cells are widely distributed throughout the renal vasculature. As the arterioles mature, renin cells differentiate into smooth muscle cells, pericytes, and mesangial cells. In adult life, renin cells are confined to the tips of the renal arterioles, thus their name juxtaglomerular cells. Juxtaglomerular cells are sensors that release renin to control blood pressure and fluid-electrolyte homeostasis. Three major mechanisms control renin release: (1) β-adrenergic stimulation, (2) macula densa signaling, and (3) the renin baroreceptor, whereby a decrease in arterial pressure leads to increased renin release whereas an increase in pressure results in decrease renin release. Cells from the renin lineage exhibit plasticity in response to hypotension or hypovolemia, whereas relentless, chronic stimulation induces concentric arterial and arteriolar hypertrophy, leading to focal renal ischemia. The renin cell baroreceptor is a nuclear mechanotransducer within the renin cell that transmits external forces to the chromatin to regulate Ren1 gene expression. In addition to mechanotransduction, the pressure sensor of the renin cell may enlist additional molecules and structures including soluble signals and membrane proteins such as gap junctions and ion channels. How these various components integrate their actions to deliver the exact amounts of renin to meet the organism needs is unknown. This review describes the nature and origins of renin cells, their role in kidney vascular development and arteriolar diseases, and the current understanding of the blood pressure sensing mechanism.

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Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells

Cited by 17 publications

References 54 publications

Genome-Wide Association Studies for Albuminuria of Nondiabetic Taiwanese Population

Genome-Wide Association Studies for Albuminuria of Nondiabetic Taiwanese Population

PIEZO Ion Channels in Cardiovascular Functions and Diseases

Renin Cells, From Vascular Development to Blood Pressure Sensing

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