Piezo1 in Digestive System Function and Dysfunction

Abstract

Piezo1, a non-selective cation channel directly activated by mechanical forces, is widely expressed in the digestive system and participates in biological functions physiologically and pathologically. In this review, we summarized the latest insights on Piezo1’s cellular effect across the entire digestive system, and discussed the role of Piezo1 in various aspects including ingestion and digestion, material metabolism, enteric nervous system, intestinal barrier, and inflammatory response within digestive system. The goal of this comprehensive review is to provide a solid foundation for future research about Piezo1 in digestive system physiologically and pathologically.

Hydrogel-Integrated Millifluidic Systems: Advancing the Fabrication of Mucus-Producing Human Intestinal Models

“…Recently, alternative mechanical stimulation through peristalsis or fluid shear stress has emerged as an effective and more physiological alternative to differentiating ISCs [14,25] and cell lines into multiple intestinal cell types [26,27], often accompanied by 3D reorganization of the monolayer. Piezo1, a mechanical sensor expressed on epithelial cells [28], plays a pivotal role in this process by regulating stem cell proliferation and differentiation [29], tight junction protein expression [30], and MUC2 production and secretion of goblet cells [31].…”