Piezo1, a novel therapeutic target to treat pulmonary arterial hypertension

Yang, Qifeng; Li, Xuanyi; Xing, Yue; Chen, Yuqin

doi:10.3389/fphys.2023.1084921

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…In animal models, Piezo1 proteins and mRNA were upregulated in isolated pulmonary artery when compared to controls. Blocking Piezo1 signaling with an intraperitoneal injection of GsMTx4, a Piezo1 channel blocker, improved the PH in mouse models 34 , 35 . These cells undergo transformation to mesenchymal cells through loss of endothelial cell markers 10 , 12 , 34 .…”

Section: Brief Introduction Of the Pathophysiology Of Phmentioning

confidence: 99%

Potential Roles of Metals in the Pathogenesis of Pulmonary and Systemic Hypertension

Hopkins,

Wessel,

Chen

et al. 2023

Int. J. Biol. Sci.

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Pulmonary and systemic hypertension (PH, SH) are characterized by vasoconstriction and vascular remodeling resulting in increased vascular resistance and pulmonary/aortic artery pressures. The chronic stress leads to inflammation, oxidative stress, and infiltration by immune cells. Roles of metals in these diseases, particularly PH are largely unknown. This review first discusses the pathophysiology of PH including vascular oxidative stress, inflammation, and remodeling in PH; mitochondrial dysfunction and metabolic changes in PH; ion channel and its alterations in the pathogenesis of PH as well as PH-associated right ventricular (RV) remodeling and dysfunctions. This review then summarizes metal general features and essentiality for the cardiovascular system and effects of metals on systemic blood pressure. Lastly, this review explores non-essential and essential metals and potential roles of their dyshomeostasis in PH and RV dysfunction. Although it remains early to conclude the role of metals in the pathogenesis of PH, emerging direct and indirect evidence implicates the possible contributions of metal-mediated toxicities in the development of PH. Future research should focus on comprehensive clinical metallomics study in PH patients; mechanistic evaluations to elucidate roles of various metals in PH animal models; and novel therapy clinical trials targeting metals. These important discoveries will significantly advance our understandings of this rare yet fatal disease, PH.

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