Pierre Mollaret (1898–1987)

Mollaret’s Syndrome: A Case Report

“…As shown in the result panel, HSV was cultured in some episodes and, in other episodes, was negative. These recurrent episodes of viral and non-viral cultures have also been documented in other scientific manuscripts with an attempt to associate them with this rare syndrome [ 1 - 4 , 7 ]…”

“…For example, studies have shown that antiphospholipid antibodies, associated with autoimmune disorders like systemic lupus erythematosus (SLE), may present in some people with Mollaret’s syndrome. Additionally, autoimmune disorders such as SLE and Behcet’s disease have also been associated with recurrent meningitis [ 1 - 4 ]…”

“…For example, MRI can help identify brain or spinal cord structural abnormalities contributing to recurrent meningitis episodes. In some cases, MRI may also reveal evidence of brain and spinal cord inflammation, which can support a diagnosis of Mollaret’s syndrome [ 1 - 4 ].…”

“…Mollaret’s meningitis is a rare disease characterized by recurrent episodes of aseptic lymphocytic meningitis that last for a few days and are followed by symptom-free intervals. The disease was first described by the French neurologist Pierre Mollaret in 1944 [ 4 ]. The episodes of meningitis are usually caused by herpes simplex virus type 2 (HSV-2) infection, although other viral and non-viral causes have also been reported.…”

“…Mollaret's meningitis is characterized by recurrent episodes of meningismus and typically goes away on its own within a week or so. On the other hand, Mollaret's lymphocytic meningitis is a recurrent or chronic inflammation of the meninges that can cause long-term neurological damage [1][2][3][4].…”