Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer

Lin, Jiumao; Feng, Jianyu; Jin, Yiyi; Yan, Zhaokun; Lai, Zijun; Peng, Jun

doi:10.3892/or.2016.5186

Cited by 21 publications

(18 citation statements)

References 30 publications

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“…Pien Tze Huang (PZH), a well-known TCM formula that originated in the Chinese Ming Dynasty >450 years ago, has been widely used in China and Southeast Asia as a remedy for various diseases, including cancer (36). It was previously demonstrated that PZH may inhibit colon cancer growth via multiple mechanisms (37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49) and PZH has exhibited promising therapeutic effects in clinical trials regarding HCC (50,51). However, the effect of PZH on HCC, including on miR-16 expression level, has not been evaluated; therefore, the present study aimed to explore the effect of PZH on the proliferation and apoptosis of the HCC BEL-7402 cell line.…”

Section: Introductionmentioning

confidence: 99%

Pien Tze Huang inhibits the growth of hepatocellular carcinoma cells by upregulating miR‑16 expression

Zhou

et al. 2017

Oncol Lett

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Abstract. Hepatocellular carcinoma (HCC) is characterized by uncontrolled proliferation and the deregulation of apoptotic signaling, although its molecular pathogenesis is not fully characterized. The ability to inhibit excessive proliferation and induce the apoptosis of cancer cells are crucial characteristics of anticancer drugs. Pien Tze Huang (PZH) is a widely used traditional Chinese medicine for the treatment of various types of cancer, and has exhibited promising therapeutic effects in clinical trials of HCC. However, the underlying mechanisms for its action are unclear. In the present study, the aim was to explore the effect of PZH on the proliferation and apoptosis of the BEL-7402 HCC cell line, and the associated mechanisms. PZH treatment significantly inhibited BEL-7402 cell viability, confluence and clonogenicity, inducing cell cycle arrest and promoting apoptosis. In addition, PZH treatment suppressed the expression of the pro-proliferative genes cyclin D1 and cyclin-dependent kinase 4, and decreased the expression of the anti-apoptotic gene Bcl-2. PZH treatment also upregulated the expression of a key microRNA (miR), miR-16. The study demonstrated that PZH can effectively inhibit cancer cell proliferation and induce apoptosis in BEL-7402 HCC cells via the upregulation of the tumor suppressor miR-16.

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Section: Introductionmentioning

confidence: 99%

Pien Tze Huang inhibits the growth of hepatocellular carcinoma cells by upregulating miR‑16 expression

Zhou

et al. 2017

Oncol Lett

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“…Natural products, including TCM, have received great interest since they have long been used to clinically treat inflammatory diseases and are relatively toxicity-free (9)(10)(11)(12). PZH is a well-known TCM formula which has been used in China and Southeast Asia for centuries to clinically treat a variety of inflammatory diseases (33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50). However, the precise mechanism of anti-inflammatory activity of PZH remains largely unknown.…”

Section: Discussionmentioning

confidence: 99%

Pien Tze Huang ameliorates DSS‑induced colonic inflammation in a mouse colitis model through inhibition of the IL‑6/STAT3 pathway

Shen

Chu

et al. 2018

Mol Med Report

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Interleukin‑6 (IL‑6)/signal transducer and activator of transcription 3 (STAT3) pathway plays essential roles in the development of inflammatory diseases including ulcerative colitis (UC). Therefore, suppression of IL‑6/STAT3 signaling provides a promising therapeutic strategy in UC. Pien Tze Huang (PZH), a well‑known traditional Chinese formula, has been used in China and Southeast Asia for centuries as a folk remedy for various inflammatory diseases. However, the molecular mechanisms of its anti‑inflammatory effects remain to be elucidated. In the present study, we generated a mouse colitis model by using dextran sulfate sodium (DSS) and evaluated the therapeutic efficacy of PZH against UC by observing the clinical manifestations. We found that PZH obviously alleviated DSS‑induced colitis symptoms, including body weight loss, rectal bleeding and stool consistency. In addition, administration of PZH profoundly prevented DSS‑induced colon shortening, and ameliorated colonic histopathological changes such as mucosal ulceration, infiltration of inflammatory cells, crypt distortion and hyperplastic epithelium. Moreover, PZH markedly inhibited the serum level of the inflammatory biomarker serum amylase A (SAA) in UC mice. Furthermore, PZH treatment significantly inhibited DSS‑induced expression of IL‑6 in colon tissues. Finally, the increased phosphorylation level of STAT3, induced either by DSS in experimental mice or by IL‑6 in the differentiated human colorectal carcinoma cells, was significantly suppressed by PZH. These results suggest that the inhibition of IL‑6/STAT3 signaling is a potential mechanism by which PZH is used in the treatment of UC.

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“…Using different human colorectal cancer cell lines and human LECs model stimulated by VEGF-C, Lin et al evaluated the effects of PZH on tumor metastasis and VEGF-C expression. It was found that PZH suppresses lymphangiogenesis via the downregulation of VEGF-C, which may be a potential molecular mechanism of inhibition of metastasis of colorectal cancer by PZH (Lin et al, 2016).…”

Section: Tcm Formula (Table 6) Experimental Research Of Tcm Formulamentioning

confidence: 99%

Traditional Chinese Medicine Regulating Lymphangiogenesis: A Literature Review

et al. 2020

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Lymphatic vessels, as an important part of the lymphatic system, form a fine vascular system in humans and play an important role in regulating fluid homeostasis, assisting immune surveillance and transporting dietary lipids. Dysfunction of lymphatic vessels can cause many diseases, including cancer, cardiovascular diseases, lymphedema, inflammation, rheumatoid arthritis. Research on lymphangiogenesis has become increasingly important over the last few decades. Nevertheless, the explicit role of regulating lymphangiogenesis in preventing and treating diseases remains unclear owing to the lack of a deeper understanding of the cellular and molecular pathways of the specific and tissue-specific changes in lymphangiopathy. TCM, consisting of compound extracted from TCM, Injections of single TCM and formula, is an important complementary strategy for treating disease in China. Lots of valuable traditional Chinese medicines are used as substitutes or supplements in western countries. As one of the main natural resources, these TCM are widely used in new drug research and development in Asia. Moreover, as a historical and cultural heritage, TCM has been widely applied to clinical research on lymphangiogenesis leveraging new technologies recently. Available studies show that TCM has an explicit effect on the regulation of lymphatic regeneration. This review aims to clarify the function and mechanisms, especially the inhibitory effect of TCM in facilitating and inhibiting lymphatic regeneration.

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Pien Tze Huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer

Cited by 21 publications

References 30 publications

Pien Tze Huang inhibits the growth of hepatocellular carcinoma cells by upregulating miR‑16 expression

Pien Tze Huang inhibits the growth of hepatocellular carcinoma cells by upregulating miR‑16 expression

Pien Tze Huang ameliorates DSS‑induced colonic inflammation in a mouse colitis model through inhibition of the IL‑6/STAT3 pathway

Traditional Chinese Medicine Regulating Lymphangiogenesis: A Literature Review

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