“…In addition, the development of pigmented tissue is related to a number of disease states and so a screen focusing on melanocytes could also play a role at the early stages of drug discovery. Examples of such diseases include albinism, piebaldism, an autosomal disorder leading to localized hypopigmentation (Thomas et al, 2004), vitiligo, an autoimmune disease leading to the destruction of melanocytes and pigment-free patches of skin in patients (Kelsh et al, 2000), hyperpigmentation, and finally skin cancer or melanoma (Kelsh et al, 2000;van Kempen and Coussens, 2002;Sturm, 2009).…”