PID1 is associated to a respiratory endotype related to occupational exposures to irritants

Andrianjafimasy, Miora; Orsi, Laurent; Margaritte‐Jeannin, Patricia; Mohamdi, Hamida; Demenais, Florence; Moual, Nicole Le; Matran, Régis; Zerimech, Farid; Dumas, Orianne; Dizier, Marie‐Hélène; Nadif, Rachel

doi:10.1016/j.freeradbiomed.2021.05.038

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…To our knowledge, a total of 12 GxE studies have been published from April 2019 to the time of writing (February 2022; Table 1), including nine using a candidate‐gene interaction approach and only three GWIS. The effects of the environment on the genetic composition and vice versa have been mostly investigated in childhood traits, except for two studies focused on adults 29,30 . Additionally, the exploration of gene interactions with early‐life environmental exposure to tobacco smoke in asthma susceptibility remains the most studied setting (Table 1).…”

Section: Interactions Between Genes and The Environmentmentioning

confidence: 99%

“…The effects of the environment on the genetic composition and vice versa have been mostly investigated in childhood traits, except for two studies focused on adults. 29,30 Additionally, the exploration of gene interactions with early-life environmental exposure to tobacco smoke in asthma susceptibility remains the most studied setting (Table 1). As a result, these studies have suggested interaction effects of known asthma genes with environmental tobacco smoke exposure during childhood (IL1RN, NFE2L2), 31,32 and a novel locus for asthma susceptibility (NAT1) 33 (Table 2).…”

Section: Inter Ac Ti Ons B E T Ween G Ene S and The Environmentmentioning

confidence: 99%

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Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Hernandez‐Pacheco

Kere

2022

Pediatric Allergy Immunology

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Investigation of gene‐environment interactions (GxE) may provide important insights into the gene regulatory framework in response to environmental factors of relevance for childhood asthma. Over the years, different methodological strategies have been applied, more recently using genome‐wide approaches. The best example to date is the major asthma locus on the 17q12‐21 chromosome region, viral infections, and airway epithelium processes where recent studies have shed much light on mechanisms in childhood asthma. However, there are challenges with the traditional single variant—single exposure interaction models, as they do not encompass the complexity and cumulative effects of multiple exposures or multiple genetic variants. As such, we need to redefine our traditional GxE thinking, and we propose in this review to expand the GxE concept by also evaluating other omics layers, such as epigenetics, transcriptomics, metabolomics, and proteomics. In addition, host factors such as age, gender, and other exposures are very likely to influence GxE effects and need firmly to be considered in future studies.

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Section: Interactions Between Genes and The Environmentmentioning

confidence: 99%

Section: Inter Ac Ti Ons B E T Ween G Ene S and The Environmentmentioning

confidence: 99%

Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Hernandez‐Pacheco

Kere

2022

Pediatric Allergy Immunology

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“…The frequency of IIA is likely underestimated, and additional data, from either WRA surveillance studies or epidemiological studies with evaluation of population attributable fractions [50], are needed specifically for irritants. Modulating factors remain poorly known, and only few gene-by-environment interactions have been investigated [41,51]. New mechanistic hypotheses may also deserve investigation such as epigenetic mechanisms, or a role of airway microbiota [52].…”

Section: Discussionmentioning

confidence: 99%

“…Although several studies support a role for antioxidant genes, such as the glutathione S-transferases (e.g., GSTP1 ) in the development of occupational asthma [40], little is known about the role of genetic susceptibility in the induction of IIA. Andrianjafimasy et al [41] found an association between SNP rs1419958 (located in the Phosphotyrosine Interaction Domain Containing 1 [ PID1 ] gene) and an asthma endotype characterized by adult-onset asthma with poor lung function, use of asthma treatments, cough and phlegm, asthma exacerbations, high neutrophil count and high level of fluorescent oxidation products (a marker of damage due to oxidative stress). When stratifying for occupational exposure to irritants, the association disappeared in those exposed to irritants, suggesting effect modification by occupational exposure.…”

Section: Mechanisms Of Irritant-induced Asthmamentioning

confidence: 99%

Update on irritant-induced occupational asthma

Ronsmans

Moual

Dumas

2022

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewIn this narrative review, we aim to highlight novel research findings on both acute/subacute irritant-induced asthma (IIA) and chronic exposure IIA (also called ‘low dose’ IIA).Recent findingsNovel case series showed that acute and subacute IIA cases had similar causal agents (e.g., acid or base aerosols/fumes, dusts, mixtures) but had occurred in different circumstances (accidents vs. regular work). Acute and subacute IIA cases had similar clinical characteristics but poorer short-term outcomes than sensitizer-induced occupational asthma patients. Novel large epidemiological studies reported associations between chronic occupational exposure to irritants and current adult-onset asthma and poor asthma control, and with a specific asthma endotype characterized by neutrophilic inflammation and oxidative stress. Recent studies reconfirmed the association of the use of disinfectants and cleaning products (especially sprays) with IIA. A role for genetic susceptibility has been suggested.SummaryRecent literature provided further understanding of both acute/subacute and chronic exposure IIA, in terms of causes, possible mechanisms, and consequences such as poor asthma control. Research is needed to clarify several aspects of IIA, including its frequency (still likely underestimated), modulating factors, and mechanisms. Research aiming at improving irritant exposure assessment, including intensity/duration, and determining relevant exposure windows would be welcome.

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Early-life ozone exposure modulates region-specific gene expression in the developing rat lung

Stevens,

Edwards,

Van Winkle

2023

Toxicology Letters

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PID1 is associated to a respiratory endotype related to occupational exposures to irritants

Cited by 3 publications

References 22 publications

Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Update on irritant-induced occupational asthma

Early-life ozone exposure modulates region-specific gene expression in the developing rat lung

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