PID Controlling Approach Based on FBG Array Measurements for Laser Ablation of Pancreatic Tissues

Korganbayev, Sanzhar; Orrico, Annalisa; Bianchi, L.; Paloschi, Davide; Wolf, Alexey A.; Dostovalov, A. V.; Saccomandi, Paola

doi:10.1109/tim.2021.3112790

Cited by 32 publications

(27 citation statements)

References 37 publications

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“…These simulation-based models are particularly advantageous for estimating the light propagation and temperature distribution due to the photothermal effect. Accurate modeling can therefore support clinicians towards new treatment paradigms and the design of procedures specifically tailored to pancreatic tissue 23 . This is also crucial to determine the optimal procedural settings and the best LA strategy with the aim to improve the final clinical outcome.…”

Section: Introductionmentioning

confidence: 99%

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Lanka

Bianchi

Farina

et al. 2022

Sci Rep

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This work reports the optical properties of porcine pancreatic tissue in the broad wavelength range of 600–1100 nm. Absorption and reduced scattering coefficients (µa and µs′) of the ex vivo pancreas were obtained by means of Time-domain Diffuse Optical Spectroscopy. We have investigated different experimental conditions—including compression, repositioning, spatial sampling, temporal stability—the effect of the freezing procedure (fresh vs frozen-thawed pancreas), and finally inter-sample variability. Good repeatability under different experimental conditions was obtained (median coefficient of variation less than 8% and ~ 16% for µa and µs′, respectively). Freezing–thawing the samples caused an irreversible threefold reduction of µs′ and no effect on µa. The absorption and reduced scattering spectra averaged over different samples were in the range of 0.12–0.74 cm−1 and 12–21 cm−1 with an inter-sample variation of ~ 10% and ~ 40% for µa and µs′, respectively. The calculated effective transport coefficient (µeff) for fresh pancreatic tissue shows that regions between 800–900 nm and 1050–1100 nm are similar and offer the lowest tissue attenuation in the considered range (i.e., µeff ranging from 2.4 to 2.7 cm−1). These data, describing specific light-pancreas interactions in the therapeutic optical window for the first time, provide pivotal information for planning of light-based thermotherapies (e.g., laser ablation) and instruction of light transport models for biophotonic applications involving this organ.

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Section: Introductionmentioning

confidence: 99%

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Lanka

Bianchi

Farina

et al. 2022

Sci Rep

Self Cite

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“…As such, for a constant power source, the time-derivative of the volumetric heat generation (i.e., Q p ) would be zero in the TPL model (Equation ( 8)). To avoid this paradox, we have considered a constant temperature at the tip of the applicator, which is maintained at 95 • C. It is noteworthy to mention that the constant temperature can be easily maintained during the thermal ablative procedures utilizing a closed-loop feedback proportionalintegral-derivative (PID) controller, as demonstrated in previous studies [39][40][41][42][43]. A comparative analysis has been conducted by comparing the temperature distributions predicted within the myocardium tissue incorporating Pennes' (Equation ( 2)), SPL (Equation ( 4)), DPL (Equation ( 6)), and TPL (Equation ( 8)) bio-heat transfer models.…”

Section: Methodsmentioning

confidence: 99%

Three-Phase-Lag Bio-Heat Transfer Model of Cardiac Ablation

Singh

Saccomandi

Melnik

2022

Fluids

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Significant research efforts have been devoted in the past decades to accurately modelling the complex heat transfer phenomena within biological tissues. These modeling efforts and analysis have assisted in a better understanding of the intricacies of associated biological phenomena and factors that affect the treatment outcomes of hyperthermic therapeutic procedures. In this contribution, we report a three-dimensional non-Fourier bio-heat transfer model of cardiac ablation that accounts for the three-phase-lags (TPL) in the heat propagation, viz., lags due to heat flux, temperature gradient, and thermal displacement gradient. Finite element-based COMSOL Multiphysics software has been utilized to predict the temperature distributions and ablation volumes. A comparative analysis has been conducted to report the variation in the treatment outcomes of cardiac ablation considering different bio-heat transfer models. The effect of variations in the magnitude of different phase lags has been systematically investigated. The fidelity and integrity of the developed model have been evaluated by comparing the results of the developed model with the analytical results of the recent studies available in the literature. This study demonstrates the importance of considering non-Fourier lags within biological tissue for predicting more accurately the characteristics important for the efficient application of thermal therapies.

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“…Additionally, they provide multi-point temperature measurements using a small-sized optical fiber embedding multiple FBG sensors, thus enabling the reconstruction of the temperature profile with accuracy for each sensor of 0.1 °C. Additional details on FBG sensors are reported in the previous papers of our group [ 12 , 56 , 57 , 58 , 59 , 60 ].…”

Section: Methodsmentioning

confidence: 99%

Gold Nanoparticles-Mediated Photothermal Therapy of Pancreas Using GATE: A New Simulation Platform

Asadi

Bianchi

Landro

et al. 2022

Cancers

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This work presents the first investigation of gold nanorods (GNRs)-based photothermal therapy of the pancreas tumor using the Monte Carlo-based code implemented with Geant4 Application for Emission Tomography (GATE). The model of a human pancreas was obtained by segmenting an abdominal computed tomography (CT) scan, and its physical and chemical properties, were obtained from experimental and theoretical data. In GATE, GNRs-mediated hyperthermal therapy, simple heat diffusion as well as interstitial laser ablation were then modeled in the pancreas tumor by defining the optical parameters of this tissue when it is loaded with GNRs. Two different experimental setups on ex vivo pancreas tissue and GNRs-embedded water were devised to benchmark the developed Monte Carlo-based model for the hyperthermia in the pancreas alone and with GNRs, respectively. The influence of GNRs on heat distribution and temperature increase within the pancreas tumor was compared for two different power values (1.2 W and 2.1 W) when the tumor was exposed to 808 nm laser irradiation and with two different laser applicator diameters. Benchmark tests demonstrated the possibility of the accurate simulating of NPs-assisted thermal therapy and reproducing the experimental data with GATE software. Then, the output of the simulated GNR-mediated hyperthermia emphasized the importance of the precise evaluation of all of the parameters for optimizing the preplanning of cancer thermal therapy. Simulation results on temperature distribution in the pancreas tumor showed that the temperature enhancement caused by raising the power was increased with time in both the tumor with and without GNRs, but it was higher for the GNR-load tumor compared to tumor alone.

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PID Controlling Approach Based on FBG Array Measurements for Laser Ablation of Pancreatic Tissues

Cited by 32 publications

References 37 publications

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Three-Phase-Lag Bio-Heat Transfer Model of Cardiac Ablation

Gold Nanoparticles-Mediated Photothermal Therapy of Pancreas Using GATE: A New Simulation Platform

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