Picture of the Month

Selimoğlu, Mukadder Ayşe

doi:10.1001/archpedi.1995.02170230125020

Cited by 20 publications

(9 citation statements)

References 0 publications

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“…HCC appears transiently in as up to 10% of healthy newborns, 9 more commonly on days 2 to 5 of life, 9 17 although it has been reported even later in a neonatal age. 14 …”

Section: Discussionmentioning

confidence: 99%

“…First reports published about HCC suggest a raised prevalence in “small for gestational age, especially preterm neonates,” 1 observation confirmed by some recent articles too 5 13 20 ; on the contrary, several new observations register HCC as a common finding also in full-term neonates. 6 8 9 14 …”

Section: Discussionmentioning

confidence: 99%

“… 2 3 HCC usually is a brief and quickly reversing phenomenon; skin returns uniformly colored in a few minutes. 8 9 …”

Section: Discussionmentioning

confidence: 99%

“…Since then, HCC has been described in a fairly broad number of reports involving neonates, 2 3 4 5 6 7 8 9 10 11 12 13 14 15 infants, 16 17 18 19 20 children, 21 22 23 24 and adult patients, 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 either as an isolated finding or as secondary to a specific condition (e.g., exercise, iatrogenic damage, and associated diseases).…”

mentioning

confidence: 99%

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Harlequin Color Change: Neonatal Case Series and Brief Literature Review

Valerio

Barlotta

Lorenzon

et al. 2015

AJP Rep

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First clinical report of Harlequin color change (HCC) phenomenon came in 1952 from Neligan and Strang. Since then, HCC has been described in a fairly broad number of clinical reports involving neonates, infants, children, and adult patients. We here present a small case series of HCC occurring in neonates, pointing out three of the different possible presentations (hemifacial, patchy scattered across the whole body, and hemiscrotal) of this phenomenon. A brief discussion and literature review encompassing epidemiology, clinical features, physiopathology, associated conditions, and differential diagnoses of HCC is then presented. In most cases, HCC represents a benign, idiopathic, and rapidly autoresolutive phenomenon, with no need for treatment. Some drugs (especially anesthetics and prostaglandin E) are thought to enhance HCC expression through their influence on the capillary tone in the peripheral vascular bed; this effect is anyway promptly reversible with drug withdrawal. Only in rare circumstances, HCC may act as a clue for serious central nervous system disorders (e.g., meningitis; hypothalamic, brain stem, or sympathetic nervous system lesions); anyway, in these rare occurrences HCC always represents an epiphenomenon of the disease, never acting as the sole sign of the underlying disorder.

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“…HCC appears transiently in as up to 10% of healthy newborns, 9 more commonly on days 2 to 5 of life, 9 17 although it has been reported even later in a neonatal age. 14 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“… 2 3 HCC usually is a brief and quickly reversing phenomenon; skin returns uniformly colored in a few minutes. 8 9 …”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Harlequin Color Change: Neonatal Case Series and Brief Literature Review

Valerio

Barlotta

Lorenzon

et al. 2015

AJP Rep

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“…The diagnosis of HCC is mainly based on the change in the skin color of specific parts of the body, with clear boundaries. The duration of onset varies from 30 s to 20 min, and the color can automatically return to normal, while the vital signs remain stable 1,14 . HCC usually occurs from the third to fifth day after birth 3,8,15 .…”

Section: Discussionmentioning

confidence: 99%

Harlequin color change in a premature infant: A case report

Yang,

Zhuang,

Zhang

et al. 2023

Clinical Case Reports

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Key Clinical MessageThis case of HCC report contributes to the knowledge of HCC in China. In this case, the longer duration of the color change observed in this case compared to previous reports, which will be useful for all medical practitioners.AbstractHarlequin color change (HCC) is a benign skin color change that lasts for a short time with no obvious physical abnormalities. Its pathogenesis is still unclear. It occurs in newborns, especially premature infants. However, few cases of HCC have been reported in China. Herein, we report a case of HCC. The infant was born at 34 + 4 weeks of gestation and was admitted to the hospital due to metabolic acidosis and neonatal pneumonia after birth. On the third day after birth, there were two red bands with obvious edges along the body centreline, and the erythema characteristics were consistent with those of HCC. The immature hypothalamus of newborns may cause the occurrence of HCC. At the same time, some drugs (midazolam), hypoxemia, and blood sampling may also be associated with HCC during neonatal hospitalization. All doctors should be thoroughly knowledgeable about the clinical characteristics of HCC and avoid using unnecessary drugs during treatment.

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