Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effect

New Insights into Detection of a Dendrobine Compound From a Novel Endophytic Trichoderma longibrachiatum Strain and Its Toxicity Against Phytopathogenic Bacteria

“…D. nobile is a medicinal plant used widely in China. To date, there are no reports on dendrobine and related compound-producing endophytic fungi isolated from D. nobile; however, studies have focused on dendrobine produced by the herb (Li et al, 2017;Meng et al, 2017). D. nobile has attracted increasing attention in medical and chemical fields because of its active ingredients.…”

Four New Picrotoxane-Type Sesquiterpenes From Dendrobium nobile Lindl

“…Compounds 1 and 2 are two new picrotoxane-type sesquiterpenes with a new carbon skeleton containing a formamide group, which may be derived from the previously reported dendrobiumane B skeleton by the C(9)-C(11) carbon bond cleavage. In the previously report, picrotoxane sesquiterpenes exhibited the angiogenesis effect against sunitinibinduced damage (Meng et al, 2017) and inhibitory activity of nerve growth factor mediated neurite outgrowth (Leon et al, 2019). Compound 3 exhibited inhibitory activity against α-glycosidase with IC 50 values of 0.97 mM.…”

“…Dendrobium nobile Lindl, the plant belongs Orchidaceae family, is one of three major plant sources of the traditional Chinese medicine “Shi Hu” in Chinese (edition 2005), which are used as a tonic to nourish the stomach and promote the production of body fluid recorded in the Chinese Pharmacopeia (Jiangsu New Medical College, 1986). The previous reports showed a series of chemical constituents isolated from D. nobile including sesquiterpenes (Zhang et al, 2007a), alkaloids (Liu and Zhao, 2003; Meng et al, 2017), bibenzyls derivatives (Zhang et al, 2007b), and glucosides (Zhao et al, 2001), some of which exhibited antitumor (Zhou et al, 2016), anti-inflammatory (Hwang et al, 2010), and immunomodulatory activities (Zhao et al, 2001).…”

“…Picrotoxane-type sesquiterpenes were one of main constituents of D. nobile , which exhibited the angiogenesis effect against sunitinibinduced damage (Meng et al, 2017) and inhibitory activity of nerve growth factor mediated neurite outgrowth (Leon et al, 2019). Our phytochemical investigation on the EtOAc extract of the stems of D. nobile led to the isolation of four new picrotoxane-type sesquiterpenes, dendroterpene A–D ( 1 – 4 ), along with four known compounds, nobilin E ( 5 ) (Zhang et al, 2007b), dendrocandin V ( 6 ) (Xiao et al, 2017), S (+)-dehydrovomifoliol ( 7 ) (Kato et al, 1977) and di-[2-(4-hydroxyphenyl)] ethyl ether ( 8 ) (Krysin et al, 2010).…”

<p>Progressive study of effects of erianin on anticancer activity</p>

“…Medicinal plants are important sources of novel therapeutic drugs that are promising for cancer treatment 9. A number of bioactive constituents from Dendrobium plants, such as polysaccharides,10 bibenzyls,11 phenanthrones,12 alkaloids,13 sesquiterpenoids,14 fluorenone,15 coumarins,16 triterpene glycosides,17 and volatile oil chemical composition, are obtained and show diverse pharmacological functions including anticancer, neuroprotective, antidiabetic, and immune-modulating activities. Erianin, which is a natural bibenzyl compound, is the most noteworthy constituent and has been used as an anti-pyretic and an analgesic in traditional Chinese medicine 18.…”