Picralima nitida as a potential source of antibacterial agents

Dzotam, Joachim K.; Kuete, Victor

doi:10.1016/bs.abr.2022.08.019

Cited by 3 publications

(1 citation statement)

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“…The plant has been reported to be beneficial in traditional medicine. Several studies have reported on some of the beneficial effects of the plant (Dzotam and Kuete, 2023;Ubulom et al, 2012;Aguwa et al, 2001). N sativa (Linn).…”

Section: Introductionmentioning

confidence: 99%

Activity-based investigation of the possible anti-diabetic potentials of some Nigerian medicinal plants

Eluehike,

Agu,

Ikponmwosa-Eweka

et al. 2023

Nig J Bas App Sci

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A major therapeutic approach presently used in managing Type 2 Diabetes mellitus is the use of a-glucosidase and a -amylase inhibitors. Hence the growing attention in the quest for medicinal plants of natural sources with inhibitory potentials on these enzymes. This study was done, therefore, to determine the inhibitory potentials of the different parts of three medicinal plants; Nigella sativum (seeds), Spondias mombin (leaves and stem bark), and Picralima nitida (seeds and mesocarp) on a-amylase and a- glucosidase as well as to determine inhibition kinetics. The in vitro a-amylase and a-glucosidase inhibitory activities of the plant extract were assessed using 3,5-dinitrosalicylic acid (DNS) and p-nitro-phenyl-a-D glucopyranoside (p-NPG) respectively. The results indicated that all plant extracts assayed exhibited better a- glucosidase inhibitory effects than the reference drug(acarbose), as indicated by the higher IC50 (76.10 μg/mL) value of the reference drug, whereas the n-hexane extract of N. sativum seeds gave the best a-amylase effect (IC50 = 35.83 μg/mL). All the extracts exhibited an “uncompetitive” type of inhibition pattern. Our findings hence support the use of these plants in the management of diabetic conditions.

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Section: Introductionmentioning

confidence: 99%