Picosecond-resolution phase-sensitive imaging of transparent objects in a single shot

Kim, Taewoo; Liang, Jinyang; Zhu, Linyu; Wang, Lihong V.

doi:10.1126/sciadv.aay6200

Cited by 33 publications

(21 citation statements)

References 52 publications

(60 reference statements)

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“…Due to the insufficient response rate of even state-of-the-art detectors compared to the electromagnetic frequency of light, direct phase measurement is not viable. Although an interesting work just came out using compressed ultrafast photography to image light-speed phase signals in a single shot [2], its performance is still rudimentary and hardly incorporated into many imaging setups. Traditional quantitative phase measurement methods can be generally categorized as interferometric and non-interferometric.…”

Section: Introductionmentioning

confidence: 99%

Non-iterative complex wave-field reconstruction based on Kramers–Kronig relations

et al. 2021

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A new computational imaging method to reconstruct the complex wave-field is reported. Due to the existence of zero frequency component, the measured signal by amplitude modulation of pupil has a spectrum similar to the one of off-axis hologram. The mathematical analogy between them is established in this paper. Based on this observation and analyticity of band-limited signal under any diffraction-limited system, an algorithm from Kramers-Kronig (KK) relations is utilized to recover the phase information only from the intensity patterns. From the sensing side, only two measurements are required at least. From the reconstruction algorithm side, our method is iteration-free and parameter-free, also without any assumption on sample characteristics. It owns several advantages over existing phase imaging methods and could provide a unique perspective to understand current computational imaging methods.

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Section: Introductionmentioning

confidence: 99%

Non-iterative complex wave-field reconstruction based on Kramers–Kronig relations

et al. 2021

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“…This configuration is useful in laser-based dark field microscopy as the laser does not need excessive expansion, but considerable light scatter is lost in the low angles to the beam stop. Laser-based dark field microscopy has also been demonstrated in several configurations, including grazing [ 3 ]/diagonal [ 4 ] incidence, total internal reflection [ 5 ]/vertical illumination [ 6 ], using an axicon lens pair [ 7 ], and using beam blocks at the objective or in the Fourier plane [ 8 , 9 ]. Applications include microsecond nanometer detection [ 6 ], flow cytometry [ 10 ], monitoring cellular organelle transport [ 11 ], and using supercontinuum laser for high-speed spectroscopy [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Dark Field and Coherent Anti-Stokes Raman (DF-CARS) Imaging of Cell Uptake of Core-Shell, Magnetic-Plasmonic Nanoparticles

et al. 2021

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Magnetic-plasmonic, Fe3O4-Au, core-shell nanoparticles are popular in many applications, most notably in therapeutics and diagnostics, and thus, the imaging of these nanostructures in biological samples is of high importance. These nanostructures are typically imaged in biological material by dark field scatter imaging, which requires an even distribution of nanostructures in the sample and, therefore, high nanoparticle doses, potentially leading to toxicology issues. Herein, we explore the nonlinear optical properties of magnetic nanoparticles coated with various thicknesses of gold using the open aperture z-scan technique to determine the nonlinear optical properties and moreover, predict the efficacy of the nanostructures in nonlinear imaging. We find that the magnetic nanoparticles coated with gold nanoseeds and thinner gold shells (ca. 4 nm) show the largest nonlinear absorption coefficient β and imaginary part of the third-order susceptibility Im χ(3), suggesting that these nanostructures would be suitable contrast agents. Next, we combine laser dark field microscopy and epi-detected coherent anti-Stokes Raman (CARS) microscopy to image the uptake of magnetic-plasmonic nanoparticles in human pancreatic cancer cells. We show the epi-detected CARS technique is suitable for imaging of the magnetic-plasmonic nanoparticles without requiring a dense distribution of nanoparticles. This technique achieves superior nanoparticle contrasting over both epi-detected backscatter imaging and transmission dark field imaging, while also attaining label-free chemical contrasting of the cell. Lastly, we show the high biocompatibility of the Fe3O4 nanoparticles with ca. 4-nm thick Au shell at concentrations of 10–100 µg/mL.

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“…15 With the help of a 20× microscopic objective lens, the phase-sensitive CUP (pCUP) system 17 can get a spatial resolution of a few micrometers and an imaging speed of 1 Tfps. To further improve the imaging speed, trillion-frame-per-second CUP (T-CUP) 18 has reached a frame rate of 10 Tfps. However, limited by the corresponding temporal resolution (0.58 ps for T-CUP or 7.6 ps for pCUP), the effective frame rate is limited to 1.75 Tfps for T-CUP or 0.135 Tfps for pCUP.…”

Section: Introductionmentioning

confidence: 99%

High-spatial-resolution ultrafast framing imaging at 15 trillion frames per second by optical parametric amplification

et al. 2020

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We report a framing imaging based on noncollinear optical parametric amplification (NCOPA), named FINCOPA, which applies NCOPA for the first time to single-shot ultrafast optical imaging. In an experiment targeting a laser-induced air plasma grating, FINCOPA achieved 50 fs-resolved optical imaging with a spatial resolution of ∼83 lp∕mm and an effective frame rate of 10 trillion frames per second (Tfps). It has also successfully visualized an ultrafast rotating optical field with an effective frame rate of 15 Tfps. FINCOPA has simultaneously a femtosecond-level temporal resolution and frame interval and a micrometer-level spatial resolution. Combining outstanding spatial and temporal resolutions with an ultrahigh frame rate, FINCOPA will contribute to high-spatiotemporal resolution observations of ultrafast transient events, such as atomic or molecular dynamics in photonic materials, plasma physics, and laser inertial-confinement fusion.

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Picosecond-resolution phase-sensitive imaging of transparent objects in a single shot

Cited by 33 publications

References 52 publications

Non-iterative complex wave-field reconstruction based on Kramers–Kronig relations

Non-iterative complex wave-field reconstruction based on Kramers–Kronig relations

Dark Field and Coherent Anti-Stokes Raman (DF-CARS) Imaging of Cell Uptake of Core-Shell, Magnetic-Plasmonic Nanoparticles

High-spatial-resolution ultrafast framing imaging at 15 trillion frames per second by optical parametric amplification

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