PICKLE associates with histone deacetylase 9 to mediate vegetative phase change in <i>Arabidopsis</i>

Hu, Tieqiang; Manuela, Darren; Hinsch, Valerie; Xu, Mingli

doi:10.1111/nph.18174

Cited by 14 publications

(18 citation statements)

References 64 publications

(164 reference statements)

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“…In this study, we developed a deficient mutant of Arabidopsis HDA9 ( hda9 ), with a single amino acid substitution, HDA9 Q337H . Similar to other HDA9 mutants, hda9 exhibits an early flowering phenotype in short-day conditions, but a delayed phase transition (Fig.3B-G & S25 -26) 30, 45 . This suggests that the 337th amino acid, glutamine, is crucial for the function of HDA9 in both aging and flowering signal pathways.…”

Section: Discussionsupporting

confidence: 63%

“…However, our work demonstrates that TAL1 can interact with HDA9 within the 5’ up-stream of the MIR156A gene body to regulate miR156A expression and chromatin remodeling (Fig. 3I & S16) 30 . Histone deacetylase family proteins exhibit high functional diversity and can function as both chromatin deacetylases and acetylases for the same member 46, 47 .…”

Section: Discussionmentioning

confidence: 73%

“…These modifications are responsible for promoting and repressing miR156 expression, respectively providing insights into the molecular mechanisms underlying the irreversible nature of age as a signaling factor. 29, 30, 31 . Several upstream transcription factors of miR156 have been identified 29, 32 , with most of them being transcriptional repressors such as GCT ( Arabidopsis MED12 ) and CCT ( MED13 ), as well as Polycomb Repressive Complex 2 (PRC2).…”

Section: Introductionsmentioning

confidence: 99%

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Novel transcriptional activator TAC3 regulates age-dependent floral transition in Chinese fir (Cunninghamia lanceolata)

Wu,

Li,

Zhu

et al. 2024

Preprint

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Plant undergo juvenile-to-adult transition to become competent for age-dependent floral induction and reproductive transition, which is of great significance for improving the seed quality and maintaining desirable genetic traits of Chinese fir, but the underlying molecular mechanize still remains unknown. Here, we investigated the function of our newly identified spermatophyte specific transcriptional co-activator TAC3 (Transcriptional Activator in Chinese fir 3) and its homologues (TAL1) in the model plant Arabidopsis. Both TAC3 and TAL1 can negatively regulate flowering, and activate miR156 expression to delay the phase transition. Moreover, we found that HDA9 and its its homologues in Chinese fir, ClHDA9, can directly binding to the promoter region of MIR156A and ClMIR156A, respectively. Directly interaction with ClHDA9 and HDA9 are necessary for the transcriptional activation of TAC3 and TAL1 on miR156, respectively. TAC3 and TAL1 also involve in the chromatin remodeling, shown as up-regulated H3K27ac level within the promoter region of ClMIR156A and MIR156A. Together, this work shows that TAC3 and its homologues are a new group of transcriptional co-activator that involving in aging-dependent flowering signal pathway of both angiosperms and gymnosperms.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 73%

Section: Introductionsmentioning

confidence: 99%

See 1 more Smart Citation

Novel transcriptional activator TAC3 regulates age-dependent floral transition in Chinese fir (Cunninghamia lanceolata)

Wu,

Li,

Zhu

et al. 2024

Preprint

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“…In Arabidopsis , trimethylation of histone H3 Lys 27 (H3K27me3) is deposited by Polycomb Repressive Complex 2 (PRC2; Hinsch et al ., 2021). PICKLE (PKL) is an ATP‐dependent Chromodomain Helicase DNA‐binding domain type 3 (CHD3) chromatin remodeler that is required for H3K27me3 deposition at some genomic locations and regulates multiple plant developmental and physiological processes (Tong et al ., 1998; Ogas et al ., 1999; Fukaki et al ., 2006; Perruc et al ., 2007; Aichinger et al ., 2009, 2011; Furuta et al ., 2011; Jing et al ., 2013, 2019a,b; Zhang et al ., 2014; Xu et al ., 2016; Zha et al ., 2017, 2020; Yang et al ., 2019; Hinsch et al ., 2021; Hu et al ., 2022; Liang et al ., 2022). A recent study revealed that PKL could interact with the transcription factors VIVIPAROUS1/ABI3‐LIKE1/2 (VAL1/2) to repress the expression of ABA INSENSITIVE 3 ( ABI3 ) and AGAMOUS‐LIKE 15 ( AGL15 ) in regulating the seed‐to‐seedling transition (Liang et al ., 2022).…”

Section: Introductionmentioning

confidence: 99%

PKL is stabilized by MMS21 to negatively regulate Arabidopsis drought tolerance through directly repressing AFL1 transcription

Jing

Yang

et al. 2023

New Phytologist

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Summary Drought stress causes substantial losses in crop production per year worldwide, threatening global food security. Identification of the genetic components underlying drought tolerance in plants is of great importance. In this study, we report that loss‐of‐function of the chromatin‐remodeling factor PICKLE (PKL), which is involved in repression of transcription, enhances drought tolerance of Arabidopsis. At first, we find that PKL interacts with ABI5 to regulate seed germination, but PKL regulates drought tolerance independently of ABI5. Then, we find that PKL is necessary for repressing the drought‐tolerant gene AFL1, which is responsible for the drought‐tolerant phenotype of pkl mutant. Genetic complementation tests demonstrate that the Chromo domain and ATPase domain but not the PHD domain are required for the function of PKL in regulating drought tolerance. Interestingly, we find that the DNA‐binding domain (DBD) is essential for the protein stability of PKL. Furthermore, we demonstrate that the SUMO E3 ligase MMS21 interacts with and enhances the protein stability of PKL. Genetic interaction analysis shows that MMS21 and PKL additively regulate plant drought tolerance. Collectively, our findings uncover a MMS21‐PKL‐AFL1 module in regulating plant drought tolerance and offer insights into a novel strategy to improve crop drought tolerance.

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“…In Arabidopsis, 18 HDA genes have been categorized into three different families: (i) reduced potassium dependence 3/histone deacetylase (RPD3/HDA1, 12 members), (ii) silent information regulator 2 (SIR2, 2 members), and (iii) plant‐specific histone deacetylase 2 (HD2, 4 members) (Hollender & Liu, 2008; Jang et al., 2003). HDA9 as a member of RPD3/HDA1 family has been extensively studied for its role as a gene suppressor involved in Arabidopsis growth and development including seed dormancy and germination (van Zanten et al., 2014), leaf development (Suzuki et al., 2018), thermomorphogenesis (Tasset et al., 2018), abiotic stress (Baek et al., 2020; Zheng et al., 2016), autophagy (Yang et al., 2020), hypocotyl elongation under short day photoperiod (Lee et al., 2022), floral transition (Chu et al., 2022; Hu et al., 2022; Kim et al., 2013, 2016; Mayer et al., 2019; Park et al., 2019; Zeng et al., 2020) and leaf senescence (Chen et al., 2016). Besides, several studies have implied that HDA9 may have an atypical function of regulating gene activation (Chen et al., 2016; Shen et al., 2019; van der Woude et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

HISTONE DEACETYLASE 9 promotes hypocotyl‐specific auxin response under shade

et al. 2023

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SUMMARYVegetative shade causes an array of morphological changes in plants called shade avoidance syndrome, which includes hypocotyl and petiole elongation, leaf hyponasty, reduced leaf growth, early flowering and rapid senescence. Here, we show that loss‐of‐function mutations in HISTONE DEACETYLASE 9 (HDA9) attenuated the shade‐induced hypocotyl elongation in Arabidopsis. However, the hda9 cotyledons and petioles under shade were not significantly different from those in wild‐type, suggesting a specific function of HDA9 in hypocotyl elongation in response to shade. HDA9 expression levels were stable under shade and its protein was ubiquitously detected in cotyledon, hypocotyl and root. Organ‐specific transcriptome analysis unraveled that shade induced a set of auxin‐responsive genes, such as SMALL AUXIN UPREGULATED RNAs (SAURs) and AUXIN/INDOLE‐3‐ACETIC ACIDs (AUX/IAAs) and their induction was impaired in hda9‐1 hypocotyls. In addition, HDA9 binding to loci of SAUR15/65, IAA5/6/19 and ACS4 was increased under shade. The genetic and organ‐specific gene expression analyses further revealed that HDA9 may cooperate with PHYTOCHROME‐INTERACTING FACTOR 4/7 in the regulation of shade‐induced hypocotyl elongation. Furthermore, HDA9 and PIF7 proteins were found to interact together and thus it is suggested that PIF7 may recruit HDA9 to regulate the shade/auxin responsive genes in response to shade. Overall, our study unravels that HDA9 can work as one component of a hypocotyl‐specific transcriptional regulatory machinery that activates the auxin response at the hypocotyl leading to the elongation of this organ under shade.

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PICKLE associates with histone deacetylase 9 to mediate vegetative phase change in Arabidopsis

Cited by 14 publications

References 64 publications

Novel transcriptional activator TAC3 regulates age-dependent floral transition in Chinese fir (Cunninghamia lanceolata)

Novel transcriptional activator TAC3 regulates age-dependent floral transition in Chinese fir (Cunninghamia lanceolata)

PKL is stabilized by MMS21 to negatively regulate Arabidopsis drought tolerance through directly repressing AFL1 transcription

HISTONE DEACETYLASE 9 promotes hypocotyl‐specific auxin response under shade

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