Pickering emulsions: challenges and opportunities in topical delivery

Marto, Joana; Ascenso, Andreia; Simões, Sandra; Almeida, António J.; Ribeiro, Helena Margarida

doi:10.1080/17425247.2016.1182489

Cited by 93 publications

(61 citation statements)

References 89 publications

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“…For this reason, emulsions are one of the most difficult and complex systems in the pharmaceutical field to develop and stabilize, requiring expertise knowledge and experience [29,30]. To prepare emulsions with the shelf life stability required for a pharmaceutical product (1-3 + years), the correct choice of surfactants, co-surfactants, fatty alcohols, polymers (steric stabilization) or solid particles (Pickering emulsions), among other excipients, must be made [29,31].…”

Section: Introductionmentioning

confidence: 99%

Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management

et al. 2020

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Human neutrophil elastase (HNE) is a serine protease that degrades matrix proteins. An excess of HNE may trigger several pathological conditions, such as psoriasis. In this work, we aimed to synthesize, characterize and formulate new HNE inhibitors with a 4-oxo-β-lactam scaffold with less toxicity, as well as therapeutic index in a psoriasis context. HNE inhibitors with 4-oxo-β-lactam scaffolds were synthesized and characterized by NMR, FTIR, melting point, mass spectrometry and elemental analysis. In vitro cytotoxicity and serine protease assays were performed. The compound with the highest cell viability (AAN-16) was selected to be incorporated in an emulsion (AAN-16 E) and in a microemulsion (AAN-16 ME). Formulations were characterized in terms of organoleptic properties, pH, rheology, droplet size distribution, in vitro drug release and in vivo psoriatic activity. All compounds were successfully synthesized according to analytical methodology, with good yields. Both formulations presented suitable physicochemical properties. AAN-16 E presented the most promising therapeutic effects in a murine model of psoriasis. Overall, new HNE inhibitors were synthesized with high and selective activity and incorporated into topical emulsions with potential to treat psoriasis.

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Section: Introductionmentioning

confidence: 99%

Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management

et al. 2020

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“…Emulsions are formed of two immiscible liquid phases, generally oil phase and water phase, with one phase organized into small droplets (inner phase), which, depending on composition and manufacturing process, have a size in a range of from tens of nanometers to several microns, and are dispersed in a distinct continuous phase (outer phase) under stabilization by an interfacial surfactant layer. Emulsions, based on structural characteristics, are made of three classical types of single emulsions, double emulsions and Pickering emulsions: single emulsions include oil-in-water (O/W) type denoting oil droplets being emulsified in a bulk aqueous phase, and vice versa, the water-in-oil (W/O) type; double emulsions include O/W/O and W/O/W emulsions; and Pickering emulsions are a special type with an emulsifier of solid NPs replacing surfactants [28].…”

Section: Vads Constructed With Emulsions Formed By Self-assembly Of Smentioning

confidence: 99%

Vaccine Adjuvant Delivery Systems Constructed Using Biocompatible Nanoparticles Formed through Self-Assembly of Small Molecules

Liu¹,

Qu²,

Liu³

et al. 2018

Immunization - Vaccine Adjuvant Delivery System and Strategies

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Subunit vaccines are playing a critical role in controlling numerous diseases and attracting more and more research interests due to their numerous advantages over conventional whole microbe-based vaccines. However, subunit vaccines are weak immunogens and thus have limited capacity in eliciting the humoral and cellular immunity against pathogens. Recently, nanoparticles (NPs) formed with certain small molecules through self-assembly have been employed as an effective carrier for subunit vaccines to play roles of adjuvant, delivery and stabilization of antigens, thus engendering a vaccine adjuvant-delivery system (VADS), which shows promises to overcome the hurdles in developing subunit vaccines. In particular, the small molecule-self-assembled NPs as a VADS can not only deliver vaccine ingredients to immune cells but also influence the immunoresponse toward a Th1 (type 1 T helper cell) and Th2 balanced pathway to establish both humoral and cellular immunity. This chapter describes the innovative VADSs based on the small molecule-self-assembled NPs, such as metal NPs (mNPs), emulsions, liposomes, and ISCOMs, which are elaborately designed for the development of subunit vaccines.

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“…They are characterized by good skin tolerability and exhibit higher effectiveness in sunscreen products. 33 Microgels are nanosized crosslinked particles that can form stable suspensions in water. They have presented different viscosity due to particle size of microgels and large surface area that allow better efficacy for cosmetic active ingredients.…”

Section: Vesicular Delivery Systemsmentioning

confidence: 99%

Herbal Cosmetics and Novel Drug Delivery Systems

Yapar¹

2017

IJPER

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Herbal cosmetics are defined as the products which prepared by or included plants and/or herbal components which are combination of many natural molecules or compounds. In this context, critical parameters that affect the final quality and stability of herbal cosmetics are the specifications of herbal inputs, structure of formulation and manufacturing process. In addition to produce according to the good manufacturing practices of cosmetics (ISO 22716) in case of being natural or organic cosmetic it needs to meet the related international standard for technical definitions and criteria of natural and organic cosmetic ingredients and products (ISO 16128). Novel drug delivery systems are used in herbal cosmetics and between them vesicular, particular and emulsion based delivery systems are most preferable delivery systems. The advantages of such systems for herbal cosmetics can be listed as; enhanced efficacy, improved stability and decrease allergic potential of some herbal substances. As a result, choosing an appropriate drug delivery system for a herbal cosmetic is able to provide increased efficacy, stability and enhanced safety of the final product. Besides these advantages above mentioned since herbal cosmetics have become more complicated the fulfillment of quality requirements either during production or after packaging and during shelf life would be critical that need to fulfill long-term stability and dermatological safety.

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Pickering emulsions: challenges and opportunities in topical delivery

Abstract: Pickering emulsions appear as a multifunctional dosage form with endless advantages. A great deal of progress is expected in this area, which might represent a renewed vision for the pharmaceutical and cosmetic industry.

Cited by 93 publications

References 89 publications

Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management

Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management

Vaccine Adjuvant Delivery Systems Constructed Using Biocompatible Nanoparticles Formed through Self-Assembly of Small Molecules

Herbal Cosmetics and Novel Drug Delivery Systems

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