Pick's Disease

Ferraro, Armando; Jervis, George A.

doi:10.1001/archneurpsyc.1936.02260100066002

Cited by 33 publications

(5 citation statements)

References 19 publications

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“…Indeed, the FTLD-tau patient with 11 years of symptoms accumulated more severe and widespread pathology compared to the FTLD-TDP patient with a longer symptom course of 16 years. It is possible that the more extensive tau accumulation in all cortical layers for PiD (68,69,(81)(82)(83)(84) and concordant severe neurodegeneration of long-range projection neurons responsible for intra-and interhemispheric connections contributed to the more widespread neuropathologic changes in the FTLD-tau patient. In contrast, TDP-43 mediated neurodegeneration was relatively focal and most prominent in upper layers I-II consistent with previous work (19,31,68,72,85,86), but unexpectedly frequent in additional layers V-VI.…”

Section: Discussionmentioning

confidence: 99%

Neuroanatomical and cellular degeneration associated with a social disorder characterized by new ritualistic belief systems in a TDP-C patient vs. a Pick patient

Ohm,

Rhodes,

Bahena

et al. 2023

Front. Neurol.

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Frontotemporal dementia (FTD) is a spectrum of clinically and pathologically heterogenous neurodegenerative dementias. Clinical and anatomical variants of FTD have been described and associated with underlying frontotemporal lobar degeneration (FTLD) pathology, including tauopathies (FTLD-tau) or TDP-43 proteinopathies (FTLD-TDP). FTD patients with predominant degeneration of anterior temporal cortices often develop a language disorder of semantic knowledge loss and/or a social disorder often characterized by compulsive rituals and belief systems corresponding to predominant left or right hemisphere involvement, respectively. The neural substrates of these complex social disorders remain unclear. Here, we present a comparative imaging and postmortem study of two patients, one with FTLD-TDP (subtype C) and one with FTLD-tau (subtype Pick disease), who both developed new rigid belief systems. The FTLD-TDP patient developed a complex set of values centered on positivity and associated with specific physical and behavioral features of pigs, while the FTLD-tau patient developed compulsive, goal-directed behaviors related to general themes of positivity and spirituality. Neuroimaging showed left-predominant temporal atrophy in the FTLD-TDP patient and right-predominant frontotemporal atrophy in the FTLD-tau patient. Consistent with antemortem cortical atrophy, histopathologic examinations revealed severe loss of neurons and myelin predominantly in the anterior temporal lobes of both patients, but the FTLD-tau patient showed more bilateral, dorsolateral involvement featuring greater pathology and loss of projection neurons and deep white matter. These findings highlight that the regions within and connected to anterior temporal lobes may have differential vulnerability to distinct FTLD proteinopathies and serve important roles in human belief systems.

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Section: Discussionmentioning

confidence: 99%

Neuroanatomical and cellular degeneration associated with a social disorder characterized by new ritualistic belief systems in a TDP-C patient vs. a Pick patient

Ohm,

Rhodes,

Bahena

et al. 2023

Front. Neurol.

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“…Pick [3] described a patient who had a progressive language disorder that was linked to left temporal lobe atrophy. This seminal paper was followed by a flood of cases [1,2], and it became clear that PPA can present in both fluent and nonfluent people. Over the next few decades, there were intermittent incidents [1,4].…”

Section: A Retrospective Delineationmentioning

confidence: 99%

“…This seminal paper was followed by a flood of cases [1,2], and it became clear that PPA can present in both fluent and nonfluent people. Over the next few decades, there were intermittent incidents [1,4].…”

Section: A Retrospective Delineationmentioning

confidence: 99%

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Primary Progressive Aphasia (PPA)

Gowda¹,

Nagaraj²

2022

Aphasia Compendium

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Primary progressive aphasia (PPA) is a rare neurological condition that affects an individual’s ability to communicate. PPA is a syndrome characterized by a ‘progressive worsening of language with preservation of the activities of daily living and evidence of relatively normal non-verbal abilities on neuropsychological testing’. It commonly appears initially as a disorder of speaking (an articulatory problem) progressing to nearly total inability to speak in its most severe stage, while comprehension remains relatively preserved. This chapter provides an overview of the characteristic features of PPA, its classification, assessment, and rehabilitation options.

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“…K. Onari und H. Spatz sowie Carl Schneider führten den bis heute gültigen Terminus Picksche Erkrankung ein ± erstere noch in Anführungszeichen. Am Ende der 1920er Jahre galt sie im deutschsprachigen Raum als Krankheitseinheit, in den Vereinigten Staaten von Amerika am Ende der 1930er Jahre[22]. Interessanterweise leugneten manche französische Autoren sowohl die Existenz einer Pickschen wie einer Alzheimerschen Erkrankung und bevorzugten den unspezifischen Begriff ¹dØmence par encØphaloseª.Erneut stellt sich die Frage, warum diese Entwicklung erst dann ± und nicht 15 Jahre früher ± einsetzen konnte.…”

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Zur Frühgeschichte der Pickschen Erkrankung

Karenberg¹

2001

Fortschr Neurol Psychiatr

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The development of the concept of Pick's disease can be divided into three periods. From 1892 on Arnold Pick reported a series of patients presenting cognitive disturbances, personality changes and focal symptoms such as aphasia and apraxia. Pick, however, like his contemporaries, did not conceive of a new nosological entity. The major event during the second period was the outline of histological characteristics like argentophilic inclusion bodies by Alois Alzheimer. During the 1910s however, Alzheimer's extremely important observation remained unnoticed. Further historical research is necessary to clarify why Alzheimer's subtype of dementia was hurriedly regarded as a disease, whereas Pick's was not. Political factors such as Kraepelin's strategic considerations seem to have played an essential role. In accordance with major research criteria of German neuropsychiatry, Pick's atrophy was constructed as a full-blown disease entity in the 1920s. This concept gained acceptance in the German and Anglo-American scientific community and was the starting point for further investigations in the 1950s and 1960s.

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Pick's Disease

Cited by 33 publications

References 19 publications

Neuroanatomical and cellular degeneration associated with a social disorder characterized by new ritualistic belief systems in a TDP-C patient vs. a Pick patient

Neuroanatomical and cellular degeneration associated with a social disorder characterized by new ritualistic belief systems in a TDP-C patient vs. a Pick patient

Primary Progressive Aphasia (PPA)

Zur Frühgeschichte der Pickschen Erkrankung

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