Piceatannol promotes apoptosis via up-regulation of microRNA-129 expression in colorectal cancer cell lines

Zhang, Haogang; Jia, Ruichun; Wang, Chun-Jing; Hu, Tianming; Wang, Fujing

doi:10.1016/j.bbrc.2014.08.150

Cited by 51 publications

(27 citation statements)

References 29 publications

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“…Another study discovered the ability of piceatannol to depress colorectal cancer growth and clarified the participation of miR-129 in the anti-cancer action of piceatannol. The findings further suggested that piceatannol could be considered as a hopeful anticancer agent for CRC [70]. As mentioned previously, the miR-129-5p/HMGB1 axis could regulate irradiation-induced autophagy and might be a principal pathway in regulating radiosensitivity of breast cancer [72].…”

Section: Mir-129 As a Therapeutic Target For Human Cancersmentioning

confidence: 85%

“…In colorectal cancer, Karaayvaz et al discovered a novel mechanism mediated by miR-129 to trigger apoptosis by suppressing a key antiapoptotic protein, B-cell lymphoma 2 (BCL2) [16], which was a central player in apoptosis of eukaryotic cells favoring survival by inhibiting cell death [69]. It was further found that piceatannol could stimulate the expression of miR-129, trigger down-regulation of Bcl-2, up-regulation of Bax and activation of caspase-3, and ultimately induce the apoptosis in CRC cells [70]. MiR-129-5p was also reported to inhibit the expression of VCP directly and play an important role in cell apoptosis of HCC [71].…”

Section: Mir-129 and Apoptosismentioning

confidence: 96%

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MicroRNA-129 in Human Cancers: from Tumorigenesis to Clinical Treatment

Gao¹,

Feng²,

Han³

et al. 2016

Cell Physiol Biochem

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Emerging evidence has shown that microRNAs (miRNAs) play essential roles in regulating human cancers development and progression. However, the underlying mechanisms remain to be further explored. MiRNAs are a class of endogenous, non-coding, 18-24 nucleotide length single-strand RNAs that moderate gene expression primarily at post-transcriptional level. There is a growing body of literature that recognizes the importance of microRNA (miR)-129 during the development of cancers. Aberrant expression of miR-129 has been detected in various types of human cancers and the validated target genes are involved in cancer-related biological processes such as DNA methylation, cell proliferation, apoptosis, cell cycle, and metastasis. In this review, we summarized the roles of miR-129 family members and their target genes in tumorigenesis and clinical treatment of human cancers, highlighting the potential roles of miR-129 as biomarkers for cancer diagnosis and prognosis, and promising tools for cancer treatment.

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Section: Mir-129 As a Therapeutic Target For Human Cancersmentioning

confidence: 85%

Section: Mir-129 and Apoptosismentioning

confidence: 96%

MicroRNA-129 in Human Cancers: from Tumorigenesis to Clinical Treatment

Gao¹,

Feng²,

Han³

et al. 2016

Cell Physiol Biochem

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“…In colorectal cancer cells, piceatannol treatment (30 μM) induced apoptosis by up-regulating miR-129, and thus down-regulating Bcl-2, which is a known target of miR-129 [186]. Besides, in prostate cancer cells, treatment with piceatannol (25 and 50 μM) inhibited proliferation, and induced cell cycle arrest and apoptosis, which might be associated with down-regulated mTOR [187].…”

Section: Experimental Studiesmentioning

confidence: 99%

Natural Polyphenols for Prevention and Treatment of Cancer

et al. 2016

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There is much epidemiological evidence that a diet rich in fruits and vegetables could lower the risk of certain cancers. The effect has been attributed, in part, to natural polyphenols. Besides, numerous studies have demonstrated that natural polyphenols could be used for the prevention and treatment of cancer. Potential mechanisms included antioxidant, anti-inflammation as well as the modulation of multiple molecular events involved in carcinogenesis. The current review summarized the anticancer efficacy of major polyphenol classes (flavonoids, phenolic acids, lignans and stilbenes) and discussed the potential mechanisms of action, which were based on epidemiological, in vitro, in vivo and clinical studies within the past five years.

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“…A combination of resveratrol and quercetin decreased miR-27a level leading to an increasing expression of zinc finger protein repressor ZBTB10 known to suppress SP activity [511]. Piceatannol, a naturally occurring analog of resveratrol from roots of Picea abies , was shown to induce apoptosis in colorectal cancer cells (HCT116 and HT29) through upregulation of miR-129 levels, and downregulation of BCL2 level, as indicated in [512]. Knockdown of miR-129 counteracted the negative effect of piceatannol on viability of HCT116 and HT29 cells [512].…”

Section: Short Non-coding Micrornas and Natural Compoundsmentioning

confidence: 99%

“…Piceatannol, a naturally occurring analog of resveratrol from roots of Picea abies , was shown to induce apoptosis in colorectal cancer cells (HCT116 and HT29) through upregulation of miR-129 levels, and downregulation of BCL2 level, as indicated in [512]. Knockdown of miR-129 counteracted the negative effect of piceatannol on viability of HCT116 and HT29 cells [512]. Resveratrol, EGCG, and α-mangostin were shown to induce apoptosis and suppress the PI3K/AKT signaling pathway [513].…”

Section: Short Non-coding Micrornas and Natural Compoundsmentioning

confidence: 99%

Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression

Ratovitski¹

2017

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Accumulating evidence shows that hallmarks of cancer include: “genetic and epigenetic alterations leading to inactivation of cancer suppressors, overexpression of oncogenes, deregulation of intracellular signaling cascades, alterations of cancer cell metabolism, failure to undergo cancer cell death, induction of epithelial to mesenchymal transition, invasiveness, metastasis, deregulation of immune response and changes in cancer microenvironment, which underpin cancer development”. Natural compounds as bioactive ingredients isolated from natural sources (plants, fungi, marine life forms) have revolutionized the field of anticancer therapeutics and rapid developments in preclinical studies are encouraging. Natural compounds could affect the epigenetic molecular mechanisms that modulate gene expression, as well as DNA damage and repair mechanisms. The current review will describe the latest achievements in using naturally produced compounds targeting epigenetic regulators and modulators of gene transcription in vitro and in vivo to generate novel anticancer therapeutics.

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Piceatannol promotes apoptosis via up-regulation of microRNA-129 expression in colorectal cancer cell lines

Cited by 51 publications

References 29 publications

MicroRNA-129 in Human Cancers: from Tumorigenesis to Clinical Treatment

MicroRNA-129 in Human Cancers: from Tumorigenesis to Clinical Treatment

Natural Polyphenols for Prevention and Treatment of Cancer

Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression

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