Piceatannol ameliorates behavioural, biochemical and histological aspects in cisplatin‐induced peripheral neuropathy in rats

Abstract

Peripheral neurotoxicity is a dose-limiting and a potentially lifelong persistent toxicity of cisplatin. This study investigated the possible protective effect of piceatannol (PIC) in a model of cisplatin-induced peripheral neuropathy in rats. PIC (10 mg/kg, i.p.) was given for 7 days, starting 2 days before cisplatin single injection (7 mg/kg, i.p.). Behavioural, biochemical and histological examinations were conducted. Cisplatin administration resulted in thermal hypoalgesia evidenced by increased paw and tail withdrawal latency times in the hotplate and tail flick tests, respectively, and reduced the abdominal constrictions in response to the acetic acid injection. Moreover, cisplatin treatment decreased rat locomotor activity and grip strength. These behavioural alterations were reversed by PIC coadministration. In addition, PIC decreased cisplatin-induced elevation in serum neurotensin and platinum accumulation in sciatic nerve. Also, PIC reversed, to a large extent, cisplatin-induced microscopical alterations in nerve axons and restored normal myelin thickness. Therefore, PIC may protect against cisplatin-induced peripheral neuropathy.

Neuroprotective Potential of Intranasally Delivered Sulforaphane-Loaded Iron Oxide Nanoparticles Against Cisplatin-Induced Neurotoxicity

“…dose of CIS disrupted neuromuscular coordination, resulted in muscle weakness, and decreased latency to fall in the hanging wire “grip” test. Our results run in accordance with Shabani et al ( 2012a , b ) and Wahdan et al ( 2021 ). This might be ascribed to the neurotoxic potential of CIS to disrupt the neuronal function in the cerebellar cortex, especially Purkinje cells which are the essential part for movement control and motor functions (Pisu et al 2004 ; Avella et al 2006 ).…”

“…In addition, CIS administration provoked thermal hyperalgesia and stimulated sensitivity to pain, this runs in accordance with several studies (Ali et al 2014 ; Sharawy et al 2015 ; Ahmad et al 2017 ; Saadati et al 2021 ; Wahdan et al 2021 ). CIS-induced thermal hyperalgesia might be attributed to the axonal deterioration in the sciatic nerve and the lower spine of the spinal cord, indicating the potential of CIS to affect small fibers that are closely involved in thermal hypersensitivity (Liu et al 2022 ).…”

“…Additionally, CIS impairs antioxidant defense efficiency and provokes an imbalance in the pro-oxidant/antioxidant system (Yadav 2019 ). CIS-induced oxidative stress is strongly correlated with neuroinflammation and results in neural shrinkage and axonal demyelination leading to slow impulse conduction (Manohar et al 2014 ; Wahdan et al 2021 ), explaining CIS-associated behavioral alterations and motor impairments.…”

Brain Protection by Methylene Blue and Its Derivative, Azur B, via Activation of the Nrf2/ARE Pathway in Cisplatin-Induced Cognitive Impairment

“…Several cytotoxic compounds including cisplatin may facilitate impairment of LTP. Cisplatin-induced cognitive impairment was documented in animals models using Morris water maze [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ], Y-maze test [ 33 , 41 , 42 , 43 , 44 ], T-maze [ 45 , 46 , 47 ], and novel object recognition test [ 9 , 48 , 49 , 50 , 51 ], including in humans in the treatment of oncological diseases using chemotherapy using cisplatin as a chemostatic [ 12 , 52 , 53 , 54 , 55 ].…”