PIBF+ extracellular vesicles from mouse embryos affect IL-10 production by CD8+ cells

Pállinger, Éva; Bognár, Zita; Bogdan, A. T.; Csabai, Timea; Ábrahám, Hajnalka; Szekeres-Barthó, Júlia

doi:10.1038/s41598-018-23112-z

Cited by 38 publications

(43 citation statements)

References 33 publications

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“…According to Pallinger and collaborators, mouse embryoderived PIBF-carrying EVs can adhere to the surface of both CD4 + and CD8 + peripheral T cells inducing IL-10 production. The abrogation of this effect by pretreatment of the EVs with an anti-PIBF antibody confirms the existence of a communication between the embryo and the maternal immune system via EVs [39]. Large vesicles rather than exosomes seemed to mediate this action (Fig.…”

Section: Evs and Progesterone-induced Blocking Factorsupporting

confidence: 62%

“…The abrogation of this effect by pretreatment of the EVs with an anti-PIBF antibody confirms the existence of a communication between the embryo and the maternal immune system via EVs [39]. The abrogation of this effect by pretreatment of the EVs with an anti-PIBF antibody confirms the existence of a communication between the embryo and the maternal immune system via EVs [39].…”

Section: Evs and Progesterone-induced Blocking Factorsupporting

confidence: 58%

“…Embryo-derived EVs have been also detected at the embryo-maternal interface in mouse implantation sites [23]. Pallinger and collaborators demonstrated that these EVs can transport progesterone-induced blocking factor (PIBF) [39]. The PIBF full-length form has been suggested to be able to modulate the invasiveness of both the trophoblast and malignant tumours [40,41] while the shorter form seems to act mainly by regulating NK cell activity.…”

Section: Evs and Progesterone-induced Blocking Factormentioning

confidence: 99%

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Embryonic extracellular vesicles as informers to the immune cells at the maternal–fetal interface

Giacomini

Alleva

Fornelli

et al. 2019

Clinical and Experimental Immunology

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Extracellular vesicle (EV) exchange is emerging as a novel method of communication at the maternal-fetal interface. The presence of the EVs has been demonstrated in the preimplantation embryo culture medium from different species, such as bovines, porcines and humans. Preimplantation embryo-derived EVs have been shown to carry molecules potentially able to modulate the local endometrial immune system. The non-classical major histocompatibility complex (MHC) class I molecule human leucocyte antigen (HLA)-G, the immunomodulatory molecule progesterone-induced blocking factor and some regulatory miRNAs species are contained in embryo-derived EV cargo. The implanted syncytiotrophoblasts are also well known to secrete EVs, with microvesicles exerting a mainly proinflammatory effect while exosomes in general mediate local immunotolerance. This review focuses on the current knowledge on the potential role of EVs released by the embryo in the first weeks of pregnancy on the maternal immune cells. Collectively, the data warrant further exploration of the dialogue between the mother and the embryo via EVs.

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Section: Evs and Progesterone-induced Blocking Factorsupporting

confidence: 62%

Section: Evs and Progesterone-induced Blocking Factorsupporting

confidence: 58%

Section: Evs and Progesterone-induced Blocking Factormentioning

confidence: 99%

See 1 more Smart Citation

Embryonic extracellular vesicles as informers to the immune cells at the maternal–fetal interface

Giacomini

Alleva

Fornelli

et al. 2019

Clinical and Experimental Immunology

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show abstract

“…Mouse embryo-derived EV adhere to the surface of both CD4+ and CD8+ murine peripheral T lymphocytes, partly via phosphatidylserine binding. Embryo-derived EV induce IL-10 production by murine peripheral CD8+ lymphocytes, and this effect is abrogated by pretreatment of the EV with anti-PIBF antibody [83]. These data suggest that the embryo communicates with the maternal immune system via EV, and that PIBF+ embryo-derived EV alter the function of peripheral lymphocytes, thus contributing to the communication between the embryo and the mother in the early stage of pregnancy.…”

Section: The Embryo Communicates With the Maternal Immune System Via mentioning

confidence: 76%

“…Embryo-derived EV are also detectable at the embryo-maternal interface in mouse implantation sites [83]. Immuno-electron microscopy revealed that among others these embryo-derived EV carry PIBF.…”

Section: The Embryo Communicates With the Maternal Immune System Via mentioning

confidence: 95%

The Role of Progesterone in Feto-Maternal Immunological Cross Talk

Szekeres-Barthó

2018

Med Princ Pract

Self Cite

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This review aims to provide a brief historical overview of the feto-maternal immunological relationship, which profoundly influences the outcome of pregnancy. The initial question posed in the 1950s by Medawar [Symp Soc Exp Biol. 1953; 7: 320–338] was based on the assumption that the maternal immune system recognizes the fetus as an allograft. Indeed, based on the association between HLA-matching and spontaneous miscarriage, it became obvious that immunological recognition of pregnancy is required for a successful gestation. The restricted expression of polymorphic HLA antigens on the trophoblast, together with the presence of nonpolymorphic MHC products, excludes recognition by both T and NK cells of trophoblast-presented antigens; however, γδ T cells, which constitute the majority of decidual T cells, are likely candidates. Indeed, a high number of activated, progesterone receptor-expressing γδ T cells are present in the peripheral blood of healthy pregnant women and, in the presence of progesterone, these cells secrete an immunomodulatory protein called progesterone-induced blocking factor (PIBF). As early as in the peri-implantation period, the embryo communicates with the maternal immune system via PIBF containing extracellular vesicles. PIBF contributes to the dominance of Th2-type reactivity which characterizes normal pregnancy by inducing increased production of Th2 cytokines. The high expression of this molecule in the decidua might be one of the reasons for the low cytotoxic activity of decidual NK cells.

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Proteome reprogramming of endometrial epithelial cells by human trophectodermal small extracellular vesicles reveals key insights into embryo implantation

et al. 2021

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Embryo implantation into the receptive endometrium is critical in pregnancy establishment, initially requiring reciprocal signalling between outer layer of the blastocyst (trophectoderm cells) and endometrial epithelium; however, factors regulating this crosstalk remain poorly understood. Although endometrial extracellular vesicles (EVs) are known to signal to the embryo during implantation, the role of embryo-derived EVs remains largely unknown. Here, we provide a comprehensive proteomic characterisation of a major class of EVs, termed small EVs (sEVs), released by human trophectoderm cells (Tsc-sEVs) and their capacity to reprogram protein landscape of endometrial epithelium in vitro. Highly purified Tsc-sEVs (30-200 nm, ALIX + , TSG101 + , CD9/63/81 + ) were enriched in known players of implantation (

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PIBF+ extracellular vesicles from mouse embryos affect IL-10 production by CD8+ cells

Cited by 38 publications

References 33 publications

Embryonic extracellular vesicles as informers to the immune cells at the maternal–fetal interface

Embryonic extracellular vesicles as informers to the immune cells at the maternal–fetal interface

The Role of Progesterone in Feto-Maternal Immunological Cross Talk

Proteome reprogramming of endometrial epithelial cells by human trophectodermal small extracellular vesicles reveals key insights into embryo implantation

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